In this paper, the hit-to-kill strategy is introduced to solve the three-dimensional (3D) robust head-pursuit (HP) interception problem considering the line-of-sight (LOS) angle constraints. Firstly, a target based relative dynamic model is proposed to be the nominal model for designing the robust HP guidance laws, where the HP interception problem is formulated as a target passively chases after the interceptor missile. Secondly, the 3D retro-proportional navigation (RPN) guidance law is reinterpreted from the point of control theory, which forces the corresponding guidance system asymptotically stable. Meanwhile, the concept of nullifying the LOS angular rates is successfully introduced to solve the 3D robust HP guidance problem via the sliding mode control. Thirdly, the LOS angles constrained robust HP guidance law is proposed based on the nonsingular terminal sliding mode control. The stabilities of the presented guidance laws are analyzed via the Lyapunov approach. The simulation results are in agreement with the theoretical statements.