Three-dimensional echocardiography for left ventricular quantification: fundamental validation and clinical applications

Heide, J.A. van der; Kleijn, Sebastiaan A.; Aly, Mohamed F.A.; Slikkerveer, Jeroen; Kamp, Otto

doi:10.1007/s12471-011-0160-y

Cited by 13 publications

(14 citation statements)

References 56 publications

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“…MLHFQ was translated into Arabic and included 21 questions. Scoring of the questionnaire was done by summating the responses to all 21 questions where each question was scaled from 0 (no effect on quality of life [QOL]), to 5 (highest impact on QOL) where higher scores reflected poorer QOL (6) .…”

Section: Methodsmentioning

confidence: 99%

Untitled

2017

IAM

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Background: Cardiac resynchronization therapy (CRT) is an established treatment of heart failure with reduced EF (HFrEF) and wide QRS complex. Nearly 30% of candidates are non-responders. One of the suggested mechanisms of inadequate response is the reduced baseline RV function; also the effect of CRT on right ventricular systolic function has not been well studied. We examined the effect of CRT on right ventricular (RV) dimensions and overall systolic function and whether RV function prior to CRT could have an impact on CRT response. Methods: 30 patients with a mean age of 51.9 ± 9.2 years including 9 (30%) females, with advanced HF (EF < 35%, LBBB > 120 ms, or non-LBBB > 150 ms, with NYHA class III or ambulatory class IV) were enrolled and underwent CRT implantation. Standard two dimensional (2D) echocardiography, tissue Doppler imaging, for assessment of Left ventricular (LV) end-diastolic (LVEDV), and end-systolic volumes (LVESV), ejection fraction, RV maximum basal (RVD1 basal), maximum mid (RVD2 mid) transverse, maximum longitudinal (RVD3 long) diameters, TAPSE, fractional area change (FAC), right ventricle index of myocardial performance(RIMP) and tricuspid lateral annular systolic velocity (S'), were done before CRT implantation and at the end of the follow up period (6 months). Patients presenting with reduction of LVESV of >15% were considered responders. Results: 20 (67%) cases were responders. Both groups were similar regarding demographic, clinical, ECG, and echocardiographic criteria at baseline however, the RA volume and RV transverse diameters were smaller and systolic function parameters were significantly better in the responders group prior to CRT compared to non-responders (NR) group. At the end of the follow up, only the responders group had further significant reduction in RV basal, mid and longitudinal diameters together with significant improvement in RV systolic function, in contrast to non-responders group who showed more RV dilatation and more decline of RV systolic function, compared to baseline readings(with P value <0.0001 for all parameters), Correlation between RV parameters before CRT implantation and CRT response was performed and ROC curves were plotted to define cutoff values for each parameter with FAC of >40 % has 85% sensitivity and 90 % specificity (P value= 0.004). TAPSE of >20 mm has 85% sensitivity and 80 % specificity (P value=0.002), S' of >10 cm/s % has 85% sensitivity and 70 % specificity (P value=0.001) and RIMP of <0.52 has 85% sensitivity and 70 % specificity (P value=0.003) in predicting CRT response. Conclusions: CRT induces RV reverse remodeling and improves RV systolic function particularly in cardiac volumetric responders. RV systolic dysfunction before CRT implantation could identify patients that might not benefit from CRT thus helping proper patient selection and optimizing CRT response.

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Section: Methodsmentioning

confidence: 99%

Untitled

2017

IAM

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“…(25) Other groups have compared real-time 3D assessment of LVEF to cardiac MR and have similarly found consistent results. (20,(26)(27)(28)(29) In most cases, 3D measurements of LV volume have been found to slightly underestimate LV volumes when compared to CMR. This can be explained by the limited spatial resolution of certain 3D-echo datasets (Figure 4), as well as difficulties in differentiating compacted myocardium from non-compacted trabeculae.…”

Section: Echocardiographymentioning

confidence: 99%

Non-invasive cardiac imaging for evaluation of cardiotoxicity in cancer patients - early detection and follow-up

Vorobiof

Silverstein

2017

SAHJ

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and early identification of cardiac toxicity during and after treatment.Non-invasive cardiac imaging techniques have been widely used for identification of patients with pre-clinical and clinical cardiotoxicity as well as for follow-up. Until recently, these modalities were predominantly limited to echocardiography and radioisotope-based nuclear imaging, but cardiac magnetic resonance has emerged and appears to may have unique advantages over traditional techniques.Coronary computed tomography, likely due to its relative lack of physiologic information, need for ionising radiation and nephrotoxic contrast, has thus far not been widely investigated in this patient population. NUCLEAR CARDIOLOGYIdentifying patients at risk for the development of cardiotoxicity is

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“…STE can be applied Three-dimensional imaging Principles 3D echocardiographic technology complements and expands upon the diagnostic capabilities of 2D imaging. While M-mode and B-mode generate a grayscale display of anatomic data in one and two dimensions, respectively, 3D echocardiography facilitates the evaluation of the entire LV in three dimensions throughout the cardiac cycle, resulting in a more accurate and comprehensive appraisal of ventricular function and morphology [24]. 3D echo has evolved over the past two decades from an unwieldy technology with complicated acquisition and processing methods to a more streamlined clinical tool that can be used for rapid cardiovascular phenotyping [25,26].…”

Section: Limitationsmentioning

confidence: 99%

“…There are two basic approaches for the acquisition and display of 3D datasets: reconstruction of a 3D image from 2D imaging in multiple planes, and real time volumetric imaging. No matter which approach is used, the technical factors associated with acquiring a high-quality 3D image are similar to those for 2D echocardiography; high temporal and spatial resolution, an experienced operator, and minimization of artifacts are the most important elements necessary for generating accurate and reproducible 3D images [24]. After the 3D dataset is acquired and volume rendered within the ultrasound system, a 3D volume is generated that can be rotated and viewed from any angle, permitting both external and internal views of the heart and providing optimal perspective for visualizing abnormalities [24].…”

Section: Acquisitionmentioning

confidence: 99%

“…No matter which approach is used, the technical factors associated with acquiring a high-quality 3D image are similar to those for 2D echocardiography; high temporal and spatial resolution, an experienced operator, and minimization of artifacts are the most important elements necessary for generating accurate and reproducible 3D images [24]. After the 3D dataset is acquired and volume rendered within the ultrasound system, a 3D volume is generated that can be rotated and viewed from any angle, permitting both external and internal views of the heart and providing optimal perspective for visualizing abnormalities [24]. This volume may then be sliced or cropped to assess the relationship, orientation, and motion pattern of anatomical structures and visualize blood flow from different perspectives [27].…”

Section: Acquisitionmentioning

confidence: 99%

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