The aim of the present research was to examine the effect of micro needling therapy on quality of life in women suffering from skin-deep varicose leg. For this purpose 20 patients with varicose veins of the lower limb with the height of 6/1 ± 163/1 cm, weight 4/6 ± 70/1 kg and fat content 6/5 ± 32/4 were selected purposefully, as the subjects. After randomization of subjects into two groups of 10 subjects for 20 weeks, every 4 weeks for a total of 5 sessions a meeting with patients was conducted using Micro needling, the control group did not have any therapeutic intervention. To analyze the data, independent t-test at a signifi cance level of 05/0> P were used. The fi ndings show that between the measured values of quality of life index before and after the test respectively, there is signifi cant increase and a signifi cant reduction of 05/0> P. The results showed that the use of micro-needling can be considered as a safe and effective treatment in enhancing the quality of life in patients with varicose veins of lower limbs.