A numerical study has been made of boundary-layer effects on the flowfield about isolated flow-through nacelles. A viscous-inviscid interacting computational model for investigating the problem was constructed by coupling a three-dimensional explicit Euler solution procedure with a compressible, "lag-entrainment," integral boundary-layer solution technique. Solutions were obtained with the interacting model for long-duct turbofan engine nacelles at a freestream Mach number of 0.8 and an angle of attack of 0 deg. The physics of the interactions between the internal and external flows and the manner in which the boundary layer alters these interactions are analyzed. The computational results are compared to experimental data.