Three dimensional fibrous scaffolds as tissue repairing templates during post-operative healing

Wang, Chenhong; Liu, Zifan; Zhang, Nuozi; Huang, Shifen; Mao, Ruoqing; Wang, Heran; Xia, Qinghua; Han, Charles C.; Xu, Shanshan; Liu, Ying

doi:10.1016/j.matdes.2021.110019

Cited by 8 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, with the continuous development of medical practice and material technology, many new methods and materials have emerged in the field of tissue repair, such as electrospinning [ 108 , 109 ], fibrous membranes [ 110 , 111 ], and scaffolds [ 112 ]. Hydrogels with good mechanical strength and biocompatibility, composed of natural or synthetic polymers, have also come to the fore [ 113 ].…”

Section: Discussionmentioning

confidence: 99%

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Ren

Yuan

Xue

et al. 2023

Materials Today Bio

Self Cite

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Ren

Yuan

Xue

et al. 2023

Materials Today Bio

Self Cite

View full text Add to dashboard Cite

“…It can be justified by the high hydrophobicity and unfavorable bioactivity of PCL fibers. [73] In addition, relatively higher density of the live cells on the PCL-CS sample was visually discernible in the micrographs. This observation qualitatively highlighted the higher viability of cultured cells on PCL-CS compared to PCL.…”

Section: Live-dead Imagingmentioning

confidence: 92%

Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions

Asvar,

Fadaie,

Azarpira

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

As an alternative for currently available hernia meshes, electrospun scaffolds represent good biocompatibility and favorable healing performance. However, they usually cannot meet the minimum mechanical requirements for a successful hernia repair. Here, a double‐faced hernia mesh comprised of electrospun polycaprolactone fibers (PCL) and chitosan nanofibers (CS) is developed to address this limitation. The privileged fibrous structure of PCL, in visceral side, can potentially guarantee the required mechanical criteria to withstand intra‐abdominal pressures and minimizing adverse adhesions. On the ventral side (facing incision), a stabilized CS layer is developed to improve cellular behavior and tissue regeneration. According to the results, PCL‐CS scaffold (thickness ≈ 500 µm) properly matches with the mechanical properties of native abdominal wall and closely meets the suggested thresholds in strength (33.3 N cm−1) and elasticity (15.26%). Superior cytocompatibility of PCL‐CS is confirmed by the in vitro studies using L929 fibroblasts and human umbilical vein endothelial cells. Full‐thickness abdominal wall defects are used to compare tissue regeneration and adverse adhesions for PCL‐CS with the polypropylene commercial mesh (Prolene) and suture groups. Gross examinations demonstrate lower rate of unfavorable adhesions in PCL‐CS compared to Prolene and suture groups. Concerning the histological analyses, PCL‐CS exhibits reduced inflammation, less fibrosis, and better tissue remodeling.

show abstract

“…Currently, many therapies have been used clinically to promote fibrocartilaginous enthesis healing, including surgical reconstruction and other non-surgical therapies such as stem cell therapy, chemical and biological agents, and biophysical modalities. 54 Although these can improve the healing of the Polyurethane (PU) 96 Good mechanical strength Biocompatibility Easy to process 155,156 High toxicity level Poly(L-lactic acid-co-e-caprolactone) (P(LLA-CL) 74 Good fibrocartilaginous enthesis in some ways, there are still limitations. Fortunately, the use of nanofibrous scaffolds can compensate for their shortcomings to some extent, showing great potential in the field of promoting fibrocartilaginous enthesis healing.…”

Section: Nanofibrous Scaffolds For the Healing Of Fibrocartilaginous ...mentioning

confidence: 99%

Nanofibrous scaffolds for the healing of the fibrocartilaginous enthesis: advances and prospects

Li¹,

Ren²,

Xue³

et al. 2023

Nanoscale Horiz.

Self Cite

View full text Add to dashboard Cite

show abstract

Three dimensional fibrous scaffolds as tissue repairing templates during post-operative healing

Cited by 8 publications

References 21 publications

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Advanced hydrogels: New expectation for the repair of organic erectile dysfunction

Novel Polycaprolactone‐Chitosan Hybrid Scaffold: A Double‐Sided Hernia Mesh for Regeneration of Abdominal Wall Defects with Minimized Adverse Adhesions

Nanofibrous scaffolds for the healing of the fibrocartilaginous enthesis: advances and prospects

Contact Info

Product

Resources

About