Three-Dimensional Finite Element Analysis of Different Implant Configurations in Enlarged First Molar Areas

Ünsal, Gökçe Soğanci

doi:10.11607/jomi.8143

Cited by 11 publications

(12 citation statements)

References 14 publications

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“…Some studies have reported the expression of STAT1 in RPMI-8226, NCI-H929, KMS-11, OPM-2, AMO-I, l-363, JJN-3, U266, MM.1S, KMS-20BM, and KMS-28BM MM cell lines (48)(49)(50). The prognostic role of related enzymes COX-2 and iNOS in MM and other malignancies has been reported (51). Other authors also discuss the involvement of STAT1, COX-2 and iNOS in all types of inflammation, angiogenesis, and metastasis of human cancer, chemical resistance and their special role in the development of drug resistance (52).…”

Section: Discussionmentioning

confidence: 99%

Carfilzomib inhibits the proliferation and apoptosis of multiple myeloma cells by inhibiting STAT1/COX-2/iNOS signaling pathway

He¹,

Tian²,

Zhao³

et al. 2022

Transl Cancer Res TCR

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Background: The ubiquitin-proteasome pathway (UPP) plays a key role in the intracellular degradation of abnormal and misfolded proteins in eukaryotic cells. Multiple myeloma (MM) is a common hematologic malignancy caused by clonal expansion of malignant plasma cells. Proteasome-targeted drugs such as carfilzomib, which is a selective proteasome inhibitor (PI), could play an important role in the treatment of diseases such as MM.Methods: MM cells were treated with different concentrations of carfilzomib and apoptosis as well as the viability of MM cells were measured by flow cytometry analysis and MTT assay. We also measured the effect of carfilzomib on the proliferation of myeloma cells by DNA incorporation of the pyrimidine analog BrdU.The effect of carfilzomib on apoptosis was detected by immunofluorescence TUNEL staining and western blot. We also verified its effect on the STAT1/COX-2/iNOS pathway by western blot.Results: Carfilzomib inhibited the growth of MM cells in a concentration-dependent manner, with the strongest inhibitory activity on RPMI-8226 cells. Carfilzomib also induced apoptosis of MM cells in a concentration-dependent manner, with the strongest effect on RPMI-8226. BrdU assay was then performed with RPMI-8226 cells, and the results showed that carfilzomib inhibited cell proliferation in a concentrationdependent manner. Immunofluorescence TUNEL staining and western blot assays showed that carfilzomib induced apoptosis in a dose-dependent manner, and promoted the expression of apoptosis-related proteins such as cleaved-caspase-3, cleaved-caspase-3, Bax and Bcl2. Western blot also verified that carfilzomib promoted STAT1 inhibition and subsequently inhibited COX-2 and iNOS.Conclusions: Inhibition of the STAT1/COX-2/iNOS signaling pathway by carfilzomib not only inhibited MM cell proliferation, but was also an important mechanism of inducing MM cell apoptosis.

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Section: Discussionmentioning

confidence: 99%

Carfilzomib inhibits the proliferation and apoptosis of multiple myeloma cells by inhibiting STAT1/COX-2/iNOS signaling pathway

He¹,

Tian²,

Zhao³

et al. 2022

Transl Cancer Res TCR

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Section: Methodsmentioning

confidence: 99%

“…Figure 1 below showed the main aspects of the three different geometries under analysis. Before carrying out the real finite element analysis, it was necessary to simulate the abutment-implant contact [14] through the constraint functions present within the Software Inventor 2021, Autodesk (California, USA) (Figures 2-4). Regarding an internal connection, due to friction between the inclined planes of the implant and the abutment, the lateral occlusal force is concentrated on the implant wall through the abutment-implant connection zone.…”

Section: Methodsmentioning

confidence: 99%

Finite Element Analysis (FEA) for a Different Type of Cono-in Dental Implant

et al. 2023

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The aim of biomechanics applied to implantology is to determine the deformative and tensional states by solving the equilibrium equations within the mandibular bone and the osseointegrated implant to ensure its stability and improve the success rate. The finite element method is a powerful numerical technique that uses computing power to derive approximate solutions for the analysis of components with very complex geometry, loads, materials, and especially the biomechanical problems analysis, which is challenging to find in vivo or in vitro. This study performs a complete FEA survey on 3 implants Cono-in with 3 different diameters 3.4 mm, 4.5 mm, and 5.2 mm with abutments inclined to 15° and evaluates the tensions that are generated in the system as a result of the application of chewing loads. In this study, the extent of the stresses developed in the peri-crestal zone of the implants with the variation of the occlusal overstress acting on them was also evaluated. Autodesk Inventor Nastran Software was used to perform this type of localized finite element analysis; With this type of analysis, it was possible to analyze the peri-crestal area of the implant more precisely through a more accurate reconstruction of the mesh element, which allowed us to solve the FEA solution mathematically. The results showed how the application of the inclined load with respect to the vertical load on a larger diameter system leads to an increase in stress.

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“…In parallel, the biomechanics of the dental implant system, the subject of this review, are undergoing remarkable development. The adoption of 3D highresolution finite element analysis (FEA) allows identifying possible imperfections in the current implant system designs (51). Extension of digital technology to dental implant component manufacture enabling custom designs having better fit within the confines of the skeletal structure of the patient.…”

Section: Concluding Remarks and Future Outlookmentioning

confidence: 99%