Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama, Kohei; Hangai, Masanori; Kimura, Yuichi; Morooka, Shigenori; Nukada, Masayuki; Akagi, Tadamichi; Ikeda, Hanako Ohashi; Matsumoto, Akiko; Yoshimura, Nagahisa

doi:10.1167/iovs.13-11677

Cited by 94 publications

(83 citation statements)

References 37 publications

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“…However, since previous studies have shown that early glaucomatous damage is primarily found in preLC tissue, the results of our cohort with early to moderate glaucoma (MD range −7.96 to 0.63 dB) are notable (21,22). A light source with a longer wavelength, or using sweptsource OCT at 1,060 nm wavelength (25), might enable accurate measurement of microcirculation within LC tissue.…”

Section: Discussionmentioning

confidence: 64%

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Chen¹,

Bojikian²,

Gupta³

et al. 2016

Quant. Imaging Med. Surg.

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Background: To investigate the differences of perfusion in the optic nerve head (ONH) between normal and glaucomatous eyes using optical microangiography (OMAG) based optical coherence tomography (OCT) angiography technique.Methods: One eye from each subject was scanned with a 68 kHz Cirrus 5000 HD-OCT-based OMAG prototype system centered at the ONH (Carl Zeiss Meditec Inc, Dublin, CA, USA). Microvascular images were generated from the OMAG dataset by detecting the differences in OCT signal between consecutive B-scans. The pre-laminar layer (preLC) was isolated by a semi-automatic segmentation program. En face OMAG images for preLC were generated using signals with highest blood flow signal intensity. ONH Results: Twenty normal and 21 glaucoma subjects were enrolled. Glaucomatous eyes had significantly lower ONH perfusion in preLC in all three perfusion metrics compared to normal eyes (P≤0.0003).Significant correlations between ONH perfusion and disease severity as well as structural changes were detected in glaucomatous eyes (P≤0.012).Conclusions: ONH perfusion detected by OMAG showed significant differences between glaucoma and normal controls and was significantly correlated with disease severity and structural defects in glaucomatous eyes. ONH perfusion measurement using OMAG may provide useful information for detection and monitoring of glaucoma.

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Section: Discussionmentioning

confidence: 64%

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Chen¹,

Bojikian²,

Gupta³

et al. 2016

Quant. Imaging Med. Surg.

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“…The limited penetration issue might be resolved by using a light source with a longer center wavelength, or using swept-source OCT at 1060-nm wavelength. 41,42 One limitation of this study is that we involved only healthy subjects to test the repeatability and reproducibility of ONH perfusion measurements using OCTA with the OMAG technique. Since this was the first study testing the repeatability and reproducibility to quantify ONH perfusion using OMAG, we started with normal subjects to make sure that the flow measurements were not affected by disease progression.…”

Section: Discussionmentioning

confidence: 99%

Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography

et al. 2016

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of optic nerve head perfusion measurements using optical coherence tomography angiography," J. Biomed. Opt. 21(6), 065002 (2016), doi: 10.1117/1.JBO.21.6.065002. Abstract. Optical coherence tomography angiography (OCTA) has increasingly become a clinically useful technique in ophthalmic imaging. We evaluate the repeatability and reproducibility of blood perfusion in the optic nerve head (ONH) measured using optical microangiography (OMAG)-based OCTA. Ten eyes from 10 healthy volunteers are recruited and scanned three times with a 68-kHz Cirrus HD-OCT 5000-based OMAG prototype system (Carl Zeiss Meditec Inc., Dublin, California) centered at the ONH involving two separate visits within six weeks. Vascular images are generated with OMAG processing by detecting the differences in OCT signals between consecutive B-scans acquired at the same retina location. ONH perfusion is quantified as flux, vessel area density, and normalized flux within the ONH for the prelaminar, lamina cribrosa, and the full ONH. Coefficient of variation (CV) and intraclass correlation coefficient (ICC) are used to evaluate intravisit and intervisit repeatability, and interobserver reproducibility. ONH perfusion measurements show high repeatability [CV ≤ 3.7% (intravisit) and ≤ 5.2% (intervisit)] and interobserver reproducibility (ICC ≤ 0.966) in all three layers by three metrics. OCTA provides a noninvasive method to visualize and quantify ONH perfusion in human eyes with excellent repeatability and reproducibility, which may add additional insight into ONH perfusion in clinical practice. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…The second clinical significance of this study's findings is that the FLCD-correspondent DHs were larger in area and longer in length than the noncorrespondent ones. This suggests the possibility that previous studies' reportedly higher DH prevalence in eyes with FLCD [9][10][11] was partially affected by these topographic characteristics of DH, which make DHs more easily detectable.…”

mentioning

confidence: 82%

“…6 Conversely, others have reported that DHs are associated with abnormalities of the lamina cribrosa (LC). 7,8 Disc hemorrhages occur frequently in eyes with focal LC defects (FLCDs) [9][10][11] and in fact show a considerable spatial relationship with them. [10][11][12] These findings signify that structural changes at the LC level lead to DH.…”

mentioning

confidence: 99%

Effect of Focal Lamina Cribrosa Defect on Disc Hemorrhage Area in Glaucoma

Kim

Jeoung

Park

2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Kim YK, Jeoung JW, Park KH. Effect of focal lamina cribrosa defect on disc hemorrhage area in glaucoma. Invest Ophthalmol Vis Sci. 2016;57:899-907. DOI:10.1167/ iovs.15-18389 PURPOSE. The purpose of this study was to evaluate the association between focal lamina cribrosa defect (FLCD) and the topographic characteristics of disc hemorrhage (DH), including area and location.METHODS. We enrolled a total of 98 primary open-angle glaucoma eyes with DH (98 subjects). In vivo lamina cribrosa (LC) images were obtained by swept-source optical coherence tomography (SS-OCT) immediately following the detection of DH. Two masked graders identified FLCD (laminar holes or disinsertions >100 lm in diameter and >30 lm in depth), defined by a customized protocol using en face images and 12 radial-orientation raster scans of SS-OCT. En face image/stereo-disc photography overlay images were evaluated to determine the spatial relationship between the respective FLCD and DH locations. A method of comparing the disc area and DH area pixel numbers was used to estimate the DH area.RESULTS. Sixty-eight of 98 eyes with DH (68.4%) had at least one FLCD. Thirty-eight of those 68 eyes with DH and at least one FLCD (55.9%) had a DH corresponding to the FLCD location (within one-half clock-hour distance from the midline). The FLCD-correspondent DHs (39 DHs) showed significantly larger areas (0.092 6 0.030 mm 2 ; P < 0.001) and more proximally located proximal ends (P < 0.028) than the noncorresponding ones (33 DHs; 0.065 6 0.024 mm 2 of area).CONCLUSIONS. The DHs that correspond to FLCD location tend to have larger areas and to be more proximally located than those without correspondence. This suggests that FLCD might affect the topographic characteristics of DH.

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Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Abstract: Citation: Takayama K, Hangai M, Kimura Y, et al. Three-dimensional imaging of lamina cribrosa defects in glaucoma using swept-source optical coherence tomography. Invest Ophthalmol Vis Sci.

Cited by 94 publications

References 37 publications

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Optic nerve head perfusion in normal eyes and eyes with glaucoma using optical coherence tomography-based microangiography

Repeatability and reproducibility of optic nerve head perfusion measurements using optical coherence tomography angiography

Effect of Focal Lamina Cribrosa Defect on Disc Hemorrhage Area in Glaucoma

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