Three-dimensional investigation of capturing particle considering particle-RBCs interaction under the magnetic field produced by an Halbach array

Ranjbari, Leyla; Zarei, Kavan; Alizadeh, As’ad; Hosseini, Omid; Aminian, Saman

doi:10.1016/j.jddst.2022.104046

Cited by 7 publications

(3 citation statements)

References 23 publications

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“…Therefore, for simulating magnetic nanoparticles in a magnetic drug targeting scenario, models like ferrofluid or inhomogeneous media are also discussed [18,28,35,115,116]. Furthermore, there are also already approaches for integrating particle-particle interaction into simulation models based on measurement results [18] or particle red blood cells (RBCs) interaction [117]. To address these points, it is planned to expand and improve our simulation model in future studies.…”

Section: Limitations Of This Studymentioning

confidence: 99%

How the Magnetization Angle of a Linear Halbach Array Influences Particle Steering in Magnetic Drug Targeting—A Systematic Evaluation and Optimization

Thalmayer,

Götz,

Fischer

2024

Symmetry

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The main challenge in magnetic drug targeting lies in steering the magnetic particles, especially in deeper body layers. For this purpose, linear Halbach arrays are currently in focus. However, to the best of the authors’ knowledge, the impact of the magnetization angle between two neighboring magnets in Halbach arrays has not been investigated for particle steering so far. Therefore, in this paper, a systematic numerical parameter study of varying the magnetization angle of linear Halbach arrays is conducted. This is completed by undertaking a typical magnetic drug targeting scenario, where magnetic particles have to be steered in an optimized manner. This includes the calculation of the magnetic flux density, its gradient, the total magnetic energy, and the resulting magnetic force based on a fitting function for the different Halbach constellations in the context of examining their potential for predicting the particle distribution. In general, increased magnetization angles result in an increased effective range of the magnetic force. However, as there is a trade-off between a weak force on the weak side of the array and a simple manufacturing process, a magnetization angle of 90∘ is recommended. For evaluating the steering performance, a numerical or experimental evaluation of the particle distribution is mandatory.

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Section: Limitations Of This Studymentioning

confidence: 99%

How the Magnetization Angle of a Linear Halbach Array Influences Particle Steering in Magnetic Drug Targeting—A Systematic Evaluation and Optimization

Thalmayer,

Götz,

Fischer

2024

Symmetry

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“…It is assumed that there is a dilute mixture of particles at which the volumetric concentration of the particles is very low, i.e., c << 1 , where c is a volume occupied by the particles in a unit volume of fluid; thus, the effect of particles on the fluid can be neglected (Furlani and Ng 2006). In addition, Brownian diffusion is the dominant particle deposition mechanism for small particles ( d p < 100 nm ), and as the particle size increases, the intensity of the Brownian force becomes rather small (Liu 2010;Ounis et al 1991). Since in the present study the particle diameter is much larger than 100 nm , Brownian diffusion is neglected.…”

Section: Governing Equationsmentioning

confidence: 99%

“…Many studies have been performed in the field of MDT in the last two decades. Experimental, numerical, and theoretical methods have been used to study different aspects of MDT (Kakavand et al 2022;Avval et al 2020;Liu et al 2019b;Ranjbari et al 2023;Koosha et al 2022). The lattice-Boltzmann method (LBM) is a category of computational fluid dynamics (CFD) approaches to simulate flow fields.…”

Section: Introductionmentioning

confidence: 99%

Effect of Particle–Particle and RBC–Particle Interactions on Capture Efficiency of Magnetic Nanocarriers Under the Influence of a Nonuniform Magnetic Field

Lahonian,

Khedri,

Aminian

et al. 2023

Iran J Sci Technol Trans Mech Eng

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In this study, the capture efficiency (CE) of magnetic carrier particles at the region of interest (ROI) in a micro-vessel was investigated. A nonuniform magnetic field produced by a Nd-Fe-B magnet was applied to capture the carrier particles at the ROI. The particle–particle and red blood cell (RBC)–carrier particle interactions were taken into account. Other parameters including carrier particle diameter, magnetic force, and non-Newtonian behavior of blood were also considered. The finite element method was used to solve the governing equations. Four cases were considered: (1) Newtonian without interaction forces, (2) Newtonian with interaction forces, (3) non-Newtonian without interaction forces, and (4) non-Newtonian with interaction forces. The results showed that for a particle diameter of 2000 nm, the CE values for the case without interaction force and with interaction force were 70% and 53%, respectively. It was found that by considering the particle–particle and RBC–carrier particle interactions for all magnet–vessel distances, the CE of carrier particles decreased, on average, by nearly 19%. At a magnet–vessel distance of 2.5 cm ($$d=2.5\,\mathrm{cm}),$$ d = 2.5 cm ) , it was seen that the CE values for case 2 and case 3 were nearly 70% and 45%, representing the maximum and minimum CE values, respectively.

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Adsorption of Dacarbazine as Anticancer Drug on Si60, C60, B30N30, Sc-Si60, Sc-C60, Sc-B30N30 Nanocages

Zhang,

Yu,

Wang

et al. 2024

Silicon

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Three-dimensional investigation of capturing particle considering particle-RBCs interaction under the magnetic field produced by an Halbach array

Cited by 7 publications

References 23 publications

How the Magnetization Angle of a Linear Halbach Array Influences Particle Steering in Magnetic Drug Targeting—A Systematic Evaluation and Optimization

How the Magnetization Angle of a Linear Halbach Array Influences Particle Steering in Magnetic Drug Targeting—A Systematic Evaluation and Optimization

Effect of Particle–Particle and RBC–Particle Interactions on Capture Efficiency of Magnetic Nanocarriers Under the Influence of a Nonuniform Magnetic Field

Adsorption of Dacarbazine as Anticancer Drug on Si60, C60, B30N30, Sc-Si60, Sc-C60, Sc-B30N30 Nanocages

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