2019
DOI: 10.1111/jon.12633
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Three‐Dimensional Lesion Phenotyping and Physiologic Characterization Inform Remyelination Ability in Multiple Sclerosis

Abstract: BACKGROUND AND PURPOSE Multiple sclerosis (MS) clinical management is based upon lesion characterization from 2‐dimensional (2D) magnetic resonance imaging (MRI) views. Such views fail to convey the lesion‐phenotype (ie, shape and surface texture) complexity, underlying metabolic alterations, and remyelination potential. We utilized a 3‐dimensional (3D) lesion phenotyping approach coupled with imaging to study physiologic profiles within and around MS lesions and their impacts on lesion phenotypes. METHODS Les… Show more

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Cited by 12 publications
(8 citation statements)
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“…Beyond size and surface area metrics, we identified a significantly higher degree of displacement or distance deviation in lesion position from the origin in MS lesions when directly compared to SVD lesion transitions using a method employing 3D visual model data. The more dynamic transitions observed here may relate to physiological differences between the two lesion types with MS lesions being associated with greater imbalances in energy demand and supply with impaired mitochondrial energy production impacting ion homeostasis 19 , metabolic derangements with increased venous blood oxygenation compared to surrounding tissue 18 , inflammatory expansion 16 , and active remodeling or degenerative responses following injury 20 .…”
Section: Discussionmentioning
confidence: 97%
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“…Beyond size and surface area metrics, we identified a significantly higher degree of displacement or distance deviation in lesion position from the origin in MS lesions when directly compared to SVD lesion transitions using a method employing 3D visual model data. The more dynamic transitions observed here may relate to physiological differences between the two lesion types with MS lesions being associated with greater imbalances in energy demand and supply with impaired mitochondrial energy production impacting ion homeostasis 19 , metabolic derangements with increased venous blood oxygenation compared to surrounding tissue 18 , inflammatory expansion 16 , and active remodeling or degenerative responses following injury 20 .…”
Section: Discussionmentioning
confidence: 97%
“…Our finding of a volume contraction was independent of the time interval between MRI studies, suggesting the promise for the early recognition of lesion changes between longitudinal MRI studies that may better indicate insights into cause. The observation of more modest surface area differences between MRI time points may be related to the more dynamic shapes associated with MS lesions, lesion age, or a combination of these factors 17,18 .…”
Section: Discussionmentioning
confidence: 99%
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“…These results are consistent with emerging evidence that the neural-glial-vascular system becomes dysfunctional in MS. 9, 21, 22 Disruption in this system, known to occur in MS, would lead to NVC and CBF dysregulation in response to neurometabolic activity, reductions in neural efficiency, and cognitive slowing. 9 In this view, the pathogenesis of MS-related cognitive impairment results from altered arterial compliance leading to impaired blood flow to active brain-regions upon neural stimulation.…”
Section: Discussionmentioning
confidence: 99%
“…While lesions can be seen in different locations, periventricular, corpus callosum, juxtacortical, brainstem, spinal cord, temporal lobe, optic nerve, cerebellum, and cerebellar peduncle involvement is typical for MS (4). Although the morphological characteristics of the lesions have been described in greater detail in recent years (5), typical features are an ovoid shape, perpendicularity to the ventricle, and size >3 mm (4).…”
Section: Introductionmentioning
confidence: 99%