Three-Dimensional Magnetic Resonance Fingerprinting in Neonates

Yu, Nali; Kim, Jee Young; Han, Dong Woo; Kim, So Young; Lee, Hye Mi; Kim, Dong-Hyun; Kim, Hyun Gi

doi:10.1097/rli.0000000000000800

Cited by 10 publications

(18 citation statements)

References 33 publications

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“…Measured values of CBF and relaxation time in most regions were correlated with corrected GA in our study. Regarding CBF, many studies have explored the associations between corrected GA and CBF 6,7,32 and between corrected GA and relaxation times, 12,13,15 and our study results are consistent with these previous findings. Cerebral blood flow has been seen to increase with corrected GA to reflect brain development 7 .…”

Section: Discussionsupporting

confidence: 93%

“…7 Regarding relaxation times, T1 and T2 values decrease with age in childhood, which is prominent in the first 2 years of infancy. 12 In preterm neonates, T1 and T2 relaxation times have showed a negative relationship with corrected GA at MRI, 13,15 reflecting a general decrease in relaxation time with higher maturation.…”

Section: Discussionmentioning

confidence: 99%

“…Another promising MRI tool to quantify brain tissue is the measurement of tissue relaxation time 11–13 . T1 and T2 relaxation times are MRI-specific measurements that reflect intrinsic brain tissue property.…”

mentioning

confidence: 99%

“…Another promising MRI tool to quantify brain tissue is the measurement of tissue relaxation time. [11][12][13] T1 and T2 relaxation times are MRI-specific measurements that reflect intrinsic brain tissue property. Brain tissue properties change according to the degree of myelination as the myelin sheath is composed of different biochemical substances.…”

mentioning

confidence: 99%

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Association of Cerebral Blood Flow and Brain Tissue Relaxation Time With Neurodevelopmental Outcomes of Preterm Neonates

Kim

Choi²,

Lee

et al. 2021

Invest Radiol

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ObjectivesBoth cerebral blood flow (CBF) and brain tissue relaxation times are known to reflect maturation in the neonatal brain. However, we do not yet know if these factors are associated with neurodevelopmental outcomes. The objective of this study was to acquire CBF and relaxation time in preterm neonates, using multidelay arterial spin labeling and synthetic magnetic resonance imaging (MRI), and show their association with later neurodevelopmental outcomes.Materials and MethodsIn this prospective study, preterm neonates were recruited, and multidelay arterial spin labeling and synthetic MRI were performed between September 2017 and December 2018. These neonates underwent the Bayley Scales of Infant Development test at 18 months of age, and both cognitive and motor outcome scores were measured. Transit time–corrected CBF and T1 and T2 relaxation time values were measured for different brain regions. The measured values were correlated with gestational age (GA) at birth and corrected GA at the MRI scan. Simple and multiple linear regression analyses were performed for the measured values and neurodevelopmental outcome scores.ResultsForty-nine neonates (median [interquartile range] GA, 30 [2] weeks, 209 [17] days; 28 boys) underwent MRI scans at or near term-equivalent age (median [interquartile range] corrected GA, 37 [2] weeks, 258 [14] days). Transit time–corrected CBF (coefficient, 0.31–0.59) and relaxation time (coefficient, −0.39 to −0.86) values showed significant correlation with corrected GA but not with GA. After controlling for GA, the frontal white matter CBF in preterm neonates showed a negative relationship with cognitive outcome scores (β = −0.97; P = 0.029). Frontal white matter T1 relaxation times showed a positive relationship with cognitive outcome scores (β = 0.03; P = 0.025) after controlling for GA.ConclusionsHigher CBF values and lower T1 relaxation times in frontal white matter were associated with poorer cognitive outcomes. As quantitative neuroimaging markers, CBF and relaxation times may help predict neurodevelopmental outcomes in preterm neonates.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Association of Cerebral Blood Flow and Brain Tissue Relaxation Time With Neurodevelopmental Outcomes of Preterm Neonates

Kim

Choi²,

Lee

et al. 2021

Invest Radiol

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“…Fortunately, relaxation values in each ROI were linearly and negatively correlated with GA, which was almost consistent with the results of the latest research that found that T1 relaxation value was linearly correlated with GA in the newborn brain by quantifying regional differences and maturation of the newborn brain using a 3D magnetic resonance fingerprint (Yu et al, 2022). In addition, we obtained a linear correlation between the T2 value and GA, which was not found by magnetic resonance fingerprinting.…”

Section: Limitationssupporting

confidence: 90%

Gestational age‐related changes in relaxation times of neonatal brain by quantitative synthetic magnetic resonance imaging

Dong

Deng²,

Xie

et al. 2023

Brain and Behavior

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Objective: This study aimed to explore the correlation between T1 and T2 relaxation times of synthetic MRI (SyMRI) and gestational age (GA) in each hemisphere of preterm and term newborns at the initial 28 days of birth. Methods: Seventy preterm and full-term infants were prospectively included in this study. All subjects completed 3.0 T routine MRI and SyMRI (MAGiC) one-stop scanning within 28 days of birth (aged 34-42 W at examination). The SyMRI postprocessing software (v8.0.4) was used to measure the T1 and T2 relaxation values of each brain region. The linear regression equations of quantitative relaxation values with GA were established to compare the variation speed in each brain region. Results: A significant linear and negative correlation was found between relaxation times and GA in the neonate cerebral cortex and subcortical gray and white matter regions (All p<.05). The relaxation time of the left centrum semiovale decreased with maximum variance with increasing GA among all white matter regions (T1: b = -51.45, β = -0.65, p < .0001; T2: b = -8.77, β = -0.71, p < .0001), whereas the right posterior limb of internal capsule showed minimal variance (T1: b = -27.94, β = -0.60, p < .0001; T2: b = -3.25, β = -0.68, p < .0001). Among all gray matter regions, the right globus pallidus and thalamus indicated the most significant decreasing degree of T1 and T2 relaxation values with GA (right globus pallidus T1: b = -33.14, β = -0.64, p < .0001; right thalamus T2: b = -3.94, β = -0.81, p < .0001), and the right and left occipital lobes indicated the least significant decreasing degree of T1 and T2 relaxation values with GA, respectively (right occipital lobes T1: b = -11.18, β = -0.26, p = .028; left occipital lobes T2: b = -1.22, β = -0.27, p = .024).Conclusions: SyMRI could quantitatively evaluate the linear changes of T1 and T2 relaxation values with GA in brain gray and white matter of preterm and term neonates.

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Evaluation of Glymphatic System Development in Neonatal Brain via Diffusion Analysis along the Perivascular Space Index

Lin,

Guo,

Liang

et al. 2024

Annals of Neurology

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ObjectiveGlymphatic system is a recently discovered macroscopic waste clearance system associated with numerous neurological diseases. However, little is known about glymphatic system development in neonates. We sought to evaluate diffusion along the perivascular space (ALPS) index, a proxy for glymphatic system function, in neonates and investigate its potential associations with maturation, sex, and preterm birth.MethodsDiffusion magnetic resonance imaging (MRI) data in 418 neonates, including 92 preterm neonates (57 males) and 326 term neonates (175 males), from the Developing Human Connectome Project were used for evaluating ALPS index. Linear regression modeling was performed to assess group differences in the ALPS index according to preterm birth and sex. Pearson's and partial correlation analysis were performed to assess the association between the ALPS index and gestational age (GA) as well as postmenstrual age (PMA) at MRI. Moderation analysis was performed to assess the moderation effect of preterm birth on the relationship between the ALPS index and PMA.ResultsCompared to term neonates, preterm neonates exhibited lower ALPS indices (p < 0.001). The ALPS index positively correlated with PMA (p = 0.004) and GA (p < 0.001). Preterm birth (p = 0.013) had a significant moderation effect on the relationship between the ALPS index and PMA. Sex had no significant direct effect (p = 0.639) or moderation effect (p = 0.333) on ALPS index.InterpretationGlymphatic system development is a dynamic process in neonates, which can be moderated by preterm birth, the ALPS index could serve as a sensitive biomarker for monitoring this process. ANN NEUROL 2024

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Three-Dimensional Magnetic Resonance Fingerprinting in Neonates

Abstract: Supplemental digital content is available in the text.

Cited by 10 publications

References 33 publications

Association of Cerebral Blood Flow and Brain Tissue Relaxation Time With Neurodevelopmental Outcomes of Preterm Neonates

Association of Cerebral Blood Flow and Brain Tissue Relaxation Time With Neurodevelopmental Outcomes of Preterm Neonates

Gestational age‐related changes in relaxation times of neonatal brain by quantitative synthetic magnetic resonance imaging

Evaluation of Glymphatic System Development in Neonatal Brain via Diffusion Analysis along the Perivascular Space Index

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