Three-Dimensional Magnetic Resonance Imaging of the Phakic Crystalline Lens during Accommodation

Sheppard, Amy L.; Evans, John; Singh, Krish Devi; Wolffsohn, James S.; Dunne, Mark; Davies, Leon N.

doi:10.1167/iovs.10-6805

Cited by 68 publications

(71 citation statements)

References 52 publications

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“…The change in lens thickness with accommodation has been well documented by multiple independent studies, and the parameters reported in the current study fall well within previously reported ranges. 27,41,[59][60][61][62] Nonhuman primate studies have demonstrated an accommodative decrease in LED of approximately 0.055 mm/D. 15,63 Only in the last decade have human studies reported in vivo changes in LED in enough people to accurately quantify this parameter in humans.…”

Section: Ocular Dimensions With Agementioning

confidence: 99%

Quantification of Age-Related and per Diopter Accommodative Changes of the Lens and Ciliary Muscle in the Emmetropic Human Eye

Richdale

Sinnott²,

Bullimore

et al. 2013

Invest. Ophthalmol. Vis. Sci.

101

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PURPOSE. To calculate age-related and per diopter (D) accommodative changes in crystalline lens and ciliary muscle dimensions in vivo in a single cohort of emmetropic human adults ages 30 to 50 years. METHODS.The right eyes of 26 emmetropic adults were examined using ultrasonography, phakometry, anterior segment optical coherence tomography, and high resolution magnetic resonance imaging. Accommodation was measured both subjectively and objectively.RESULTS. In agreement with previous research, older age was linearly correlated with a thicker lens, steeper anterior lens curvature, shallower anterior chamber, and lower lens equivalent refractive index (all P < 0.01). Age was not related to ciliary muscle ring diameter (CMRD) or lens equatorial diameter (LED). With accommodation, lens thickness increased (þ0.064 mm/D, P < 0.001), LED decreased (À0.075 mm/D, P < 0.001), CMRD decreased (À0.105 mm/D, P < 0.001), and the ciliary muscle thickened anteriorly (þ0.013 to þ0.026 mm/D, P < 0.001) and thinned posteriorly (À0.011 to À0.015, P < 0.01). The changes per diopter of accommodation in LED, CMRD, and ciliary muscle thickness were not related to subject age.CONCLUSIONS. The per diopter ciliary muscle contraction is age independent, even as total accommodative amplitude declines. Quantifying normal biometric dimensions of the accommodative structures and changes with age and accommodative effort will further the development of new IOLs designed to harness ciliary muscle forces. (Invest Ophthalmol Vis Sci.

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Section: Ocular Dimensions With Agementioning

confidence: 99%

Quantification of Age-Related and per Diopter Accommodative Changes of the Lens and Ciliary Muscle in the Emmetropic Human Eye

Richdale

Sinnott²,

Bullimore

et al. 2013

Invest. Ophthalmol. Vis. Sci.

101

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“…On the other hand, the positive use of MRI in real-time measurements of water transport in the lens has been reported by previous studies (27)(28)(29). Sheppard et al showed the successful use of MRI for the measurement of mean crystalline lens thickness during accommodation (13). Van Rijn et al reported that IOLs are compatible with MRI (12).…”

Section: Discussionmentioning

confidence: 89%

“…The results of a study performed by Van Rijn et al demonstrated that IOLs are compatible with MRI at a magnetic field strength of 7 Tesla (12). Sheppard et al after evaluation of three-dimensional MRI of the phakic crystalline lens during accommodation, reported that mean crystalline lens thickness increased during accommodation (13).…”

Section: Introductionmentioning

confidence: 99%

Abnormal High Signal Intensity Discovered in Eye Lenses in Routine Brain MRI; Correlation with Ophthalmologist Examination

et al. 2017

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Objectives: The aim of this study was to determine the possible role of brain magnetic resonance imaging (MRI) in cataract detection. Patients and Methods: This study was performed on patients who were referred to Shahid Faghihi hospital with a known disease for brain MRI. Patients were classified in two groups of case and controls. Cases were 44 eyes with abnormal signal of the lens and controls were 88 eyes with normal signal intensity of the lens. All patients underwent an ophthalmological examination and the presence of cataract and intraocular lens (IOL) was assessed in these patients. Average lens signal, average muscle signal, average fat signal, lens to muscle signal ratio, and average lens signal to average fat signal ratio were recorded. Results: The mean of the average lens signal in the case group was significantly higher than controls (370 versus 161, respectively) (P value < 0.0001). Sixteen (36.4%) out of 44 eyes in the case group had cataract, but 48 (54.5%) of 88 eyes in the control group had cataract (P value = 0.049). In the case group, 18.2% had IOL, and this was 6.8% in the controls (P value = 0.046). The mean of the average lens signal in eyes with cataract was 218.5 and in normal eyes, it was 249.1 (P value = 0.36). In eyes with IOL, the mean of the average lens signal was 347.5 and in normal eyes, this was 223.1 (P value = 0.036). Conclusion: Cataract in eyes with abnormal lens signal was significantly lower than eyes with normal lens average signal. The lens signal in eyes with cataract was similar to eyes without cataract. So, average lens signal in brain MRI does not lead to early detection of cataract.

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“…The lens reduces in diameter, and becomes thicker axially accompanied by a similar reduction in anterior chamber depth and a small reduction in vitreous depth [2,3]. Strenk et al reported increase in cross-sectional area of the anterior portion of the lens with accommodation [4], but others had reported small decreases in cross-sectional area with accommodation [5,6]. Small increases [5] or no changes [6,7] in volume with accommodation have been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Strenk et al reported increase in cross-sectional area of the anterior portion of the lens with accommodation [4], but others had reported small decreases in cross-sectional area with accommodation [5,6]. Small increases [5] or no changes [6,7] in volume with accommodation have been reported. Accompanying the changes in the external geometry of the lens is a change in the gradient refractive index distribution (GRIN) inside the lens [8].…”

Section: Introductionmentioning

confidence: 99%

Change in human lens dimensions, lens refractive index distribution and ciliary body ring diameter with accommodation

Khan

Pope

Verkicharla

et al. 2018

Biomed. Opt. Express

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Abstract:We investigated changes in ciliary body ring diameter, lens dimensions and lens refractive index distributions with accommodation in young adults. A 3T clinical magnetic resonance imaging scanner imaged right eyes of 38 18-29 year old participants using a multiple spin echo sequence to determine accommodation-induced changes along lens axial and equatorial directions. Accommodation stimuli were approximately 1 D and 5 D. With accommodation, ciliary body ring diameter, and equatorial lens diameter decreased (-0.43 ± 0.31 mm and -0.30 ± 0.23 mm, respectively), and axial lens thickness increased ( + 0.34 ± 0.16 mm). Lens shape changes cause redistribution of the lens internal structure, leading to change in refractive index distribution profiles. With accommodation, in the axial direction refractive index profiles became flatter in the center and steeper near the periphery of the lens, while in the equatorial direction they became steeper in the center and flatter in the periphery. The results suggest that the anatomical accuracy of lens optical models can be improved by accounting for changes in the refractive index profile during accommodation.

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Three-Dimensional Magnetic Resonance Imaging of the Phakic Crystalline Lens during Accommodation

Cited by 68 publications

References 52 publications

Quantification of Age-Related and per Diopter Accommodative Changes of the Lens and Ciliary Muscle in the Emmetropic Human Eye

Quantification of Age-Related and per Diopter Accommodative Changes of the Lens and Ciliary Muscle in the Emmetropic Human Eye

Abnormal High Signal Intensity Discovered in Eye Lenses in Routine Brain MRI; Correlation with Ophthalmologist Examination

Change in human lens dimensions, lens refractive index distribution and ciliary body ring diameter with accommodation

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