The study aims to explore the combined impact of activation energy and entropy generation on Prandtl‐Eyring fluid flow within a curved channel, considering Hall and ion slip effects, alongside the influence of nonlinear thermal radiation on heat transfer. This research is pivotal as it delves into the multifaceted relationship among these factors, offering important implications spanning various fields, from engineering to physics. Notably, the findings highlight that heightened nonlinear thermal radiation does not solely elevate entropy generation but also amplifies the Bejan number, signifying a substantial effect on fluid flow dynamics. Furthermore, the investigation reveals an intriguing correlation: lower concentrations paired with higher Arrhenius activation energy values correspond to heightened chemical reaction rates, presenting valuable insights applicable to reaction engineering and material sciences. Additionally, exploring the impact of activation energy and entropy generation within this fluid model presents a unique approach to understanding complex fluid dynamics and heat transfer phenomena, offering insights crucial for various engineering applications, particularly in fluid dynamics, thermal sciences, and materials engineering.