Three-dimensional MR Elastography Depicts Liver Inflammation,                     Fibrosis, and Portal Hypertension in Chronic Hepatitis B or C

Shi, Yu; Qi, Yafei; Lan, Gongyu; Wu, Qi‐Jun; Ma, Bing; Zhang, Xianyi; Ji, Ruoyun; Ma, Yujia; Hong, Yang

doi:10.1148/radiol.2021202804

Cited by 51 publications

(44 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There may be other explanations why ICG Cl is lower than Cl PV . A reversible distribution of ICG may take place to different non‐hepatic tissues 32,33 or a small contamination with a low‐clearance metabolite of ICG may have occurred after continuous infusion 34 …”

Section: Discussionmentioning

confidence: 99%

“…There may be other explanations why ICG Cl is lower than Cl PV . A reversible distribution of ICG may take place to different non-hepatic tissues 32,33 or a small contamination with a low-clearance metabolite of ICG may have occurred after continuous infusion. 34 All in all, Cl PV was closely correlated to the steady-state clearance in the present study, and it may be the best initial slope ICG-clearance estimate of liver cell uptake.…”

Section: Table 3 Correlations Between Pertinent Biochemical and Hemod...mentioning

confidence: 99%

See 1 more Smart Citation

Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

Möller

Henriksen

Sjöstedt

et al. 2022

J of Gastro and Hepatol

View full text Add to dashboard Cite

Background and Aim:The study was undertaken in order to compare single injection indocyanine green (ICG)-clearances with the steady-state ICG-clearance (ICG Cl ) in patients with cirrhosis in order to assess the most accurate estimate for ICG-clearance and to relate the ICG-clearances to established indicators of liver dysfunction. Methods: Thirty-eight patients (male 29) with cirrhosis (Child-Turcotte class A 8, class B 21, and class C 9) were studied during a hemodynamic investigation. A single injection of ICG was followed by blood samples for 5, 10, 15, and 20 min. The dose/plasma area clearance (Cl A ) and plasma volume • initial slope clearance (Cl PV ) were determined and compared with the steady-state infusion/plasma concentration ratio clearance (ICG Cl ). Results: The Cl A (310; 214; 502 mL/min) and Cl PV (294; 164; 481 mL/min) correlated closely with ICG Cl (243; 120; 383 mL/min [median; interquartile range], R = 0.95-0.98, P < 0.000), but were significantly higher than ICG Cl (P < 0.001). All three clearance measures correlated significantly with biochemical and hemodynamic variables of liver dysfunction (P < 0.05-0.000). All three ICG-clearances showed significantly lower values in patients with ascites compared to those without, and lower ICG-clearance values were present in patients with esophageal varices compared to those without (P < 0.05-0.002). Conclusion: Single injection markers (Cl A and Cl PV ) of the steady-state ICG-clearance as derived from the ICG-retention curve and the plasma volume correlate with ICG Cl and established variables of portal hypertension and liver cell bile excretory dysfunction. Therefore, these markers can safely replace the more costly ICG Cl .

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Table 3 Correlations Between Pertinent Biochemical and Hemod...mentioning

confidence: 99%

Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

Möller

Henriksen

Sjöstedt

et al. 2022

J of Gastro and Hepatol

View full text Add to dashboard Cite

show abstract

“…A variety of factors, including cell types, extracellular matrix deposition, cellularity, and fluid transport, alter the mechanical properties of biological organization [ 9 , 10 ]. MRE can also be applied on the liver [ 11 , 12 ]. MRE can measure displacement due to propagating mechanical waves, from which biomechanical properties of tumors, such as stiffness, can be calculated [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…MRE can measure displacement due to propagating mechanical waves, from which biomechanical properties of tumors, such as stiffness, can be calculated [ 13 ]. However, stiffness quantified by MRE was always used for depicting diffuse liver disease, such as liver inflammation, fibrosis, and portal hypertension in chronic hepatitis patients [ 11 ]. To update, nearly all elastography techniques measure stiffness without taking into account the viscoelastic, anisotropic, and nonlinear properties of most living tissues.…”

Section: Introductionmentioning

confidence: 99%

Added Value of Viscoelasticity for MRI-Based Prediction of Ki-67 Expression of Hepatocellular Carcinoma Using a Deep Learning Combined Radiomics (DLCR) Model

Zhou

et al. 2022

Cancers

View full text Add to dashboard Cite

This study aimed to explore the added value of viscoelasticity measured by magnetic resonance elastography (MRE) in the prediction of Ki-67 expression in hepatocellular carcinoma (HCC) using a deep learning combined radiomics (DLCR) model. This retrospective study included 108 histopathology-proven HCC patients (93 males; age, 59.6 ± 11.0 years) who underwent preoperative MRI and MR elastography. They were divided into training (n = 87; 61.0 ± 9.8 years) and testing (n = 21; 60.6 ± 10.1 years) cohorts. An independent validation cohort including 43 patients (60.1 ± 11.3 years) was included for testing. A DLCR model was proposed to predict the expression of Ki-67 with cMRI, including T2W, DW, and dynamic contrast enhancement (DCE) images as inputs. The images of the shear wave speed (c-map) and phase angle (φ-map) derived from MRE were also fed into the DLCR model. The Ki-67 expression was classified into low and high groups with a threshold of 20%. Both c and φ values were ranked within the top six features for Ki-67 prediction with random forest selection, which revealed the value of MRE-based viscosity for the assessment of tumor proliferation status in HCC. When comparing the six CNN models, Xception showed the best performance for classifying the Ki-67 expression, with an AUC of 0.80 ± 0.03 (CI: 0.79–0.81) and accuracy of 0.77 ± 0.04 (CI: 0.76–0.78) when cMRI were fed into the model. The model with all modalities (MRE, AFP, and cMRI) as inputs achieved the highest AUC of 0.90 ± 0.03 (CI: 0.89–0.91) in the validation cohort. The same finding was observed in the independent testing cohort, with an AUC of 0.83 ± 0.03 (CI: 0.82–0.84). The shear wave speed and phase angle improved the performance of the DLCR model significantly for Ki-67 prediction, suggesting that MRE-based c and φ-maps can serve as important parameters to assess the tumor proliferation status in HCC.

show abstract

“…MRE has emerged as a method for the quantitative mapping of biomechanical properties of different biological tissues. Several links between viscoelasticity and clinical endpoints have been identi ed and are well established in assessing hepatic brosis and in ammation [4][5][6][7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Feasibility of In Vivo MR Elastography of Mesenteric Adipose Tissue in Crohn’s Disease

Jensen

Loch

Kamphues

et al. 2022

Preprint

View full text Add to dashboard Cite

Although there is growing evidence that functional involvement and structural changes of mesenteric adipose tissue (MAT) influence the course of Crohn's disease (CD), its viscoelastic properties remain elusive. Therefore, we aimed to investigate the viscoelastic properties of MAT in CD using MR elastography (MRE). In this prospective proof-of-concept study, 31 subjects (CD: n = 11, healthy controls: n = 20) were investigated using MRE at 1.5Tesla with frequencies of 40-70Hz. Volumes of interest in MAT were drawn adjacent to CD lesions (MATCD) and on the opposite side without adjacent bowel lesions in patients (MATCD_Opp) and controls (MATCTRL). A statistically significant decrease in mean shear wave speed (SWS) of 7% was found for MATCD_Opp vs. MATCTRL (0.76 ± 0.05m/s vs. 0.82 ± 0.04m/s, p = 0.012), whereas there was a nonsignificant trend with an 8% increase for MATCD vs. MATCD_Opp (0.82 ± 0.07m/s vs. 0.76 ± 0.05m/s, p = 0.098) and no difference for MATCD vs. MATCTRL. Preliminary AUC analysis showed diagnostic accuracy in detecting CD to be excellent for SWS of MATCD_Opp (AUC = 0.82) but poor for SWS of MATCD (AUC = 0.52). This study demonstrates the feasibility of MRE of MAT and presents preliminary reference values for CD patients and healthy controls. Our results motivate further studies for the biophysical characterization of MAT in inflammatory bowel disease.

show abstract

Three-dimensional MR Elastography Depicts Liver Inflammation, Fibrosis, and Portal Hypertension in Chronic Hepatitis B or C

Cited by 51 publications

References 28 publications

Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

Added Value of Viscoelasticity for MRI-Based Prediction of Ki-67 Expression of Hepatocellular Carcinoma Using a Deep Learning Combined Radiomics (DLCR) Model

Feasibility of In Vivo MR Elastography of Mesenteric Adipose Tissue in Crohn’s Disease

Contact Info

Product

Resources

About