Three‐dimensional multi‐gene expression maps reveal cell fate changes associated with laterality reversal of zebrafish habenula

Abstract

Along the developmental processes upon forming a functional brain in vertebrates, many differentiating neurons will gather into structurally distinguishable yet functionally coherent or connected clusters of neurons (nuclei or nodes) that contain different cellular characteristics.Proper generation of these compartmentalized and specialized neuronal organizations is needed for facilitating the processing of complex input and output activities within each vertebrate brain (Chatterjee &

3D RNA profile of habenulae in the catsharkScyliorhinus canicula: a reference in jawed vertebrates

“…This trait exemplifies the difficulties encountered when comparing the mouse and zebrafish. The zebrafish habenulae exhibit asymmetries, which have been extensively characterized (Gamse et al, 2003;Kuan et al, 2007;Bianco and Wilson, 2009;deCarvalho et al, 2014;Wang et al, 2021) and have no equivalent in mammals, even though subtle size and shape differences between the right and the left habenulae have been detected in the latter (Ahumada-Galleguillos et al, 2017;Hitti et al, 2022). These difficulties may be related to lineage specific diversifications, obscuring similarities reflecting conserved ancestral features of organ organization.…”