Three-Dimensional Nanoprinting via Direct Delivery

Souza, João Francisco Ventrici de; Liu, Yang; Wang, Shuo; Dörig, Pablo; Kuhl, Tonya L.; Frommer, Jane; Liu, Gang-yu

doi:10.1021/acs.jpcb.7b06978

Cited by 43 publications

(49 citation statements)

References 47 publications

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“…More and more applications demand a detailed understanding of nanodroplets such as for instance 3D nanoprinting, nanomedicine, phase-change cooling using nanosprays and microdeposition processes [1][2][3]. Remarkable achievements have been obtained rather recently by printing organic molecules at the nanoscale [4].…”

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confidence: 99%

How Wettability Controls Nanoprinting

et al. 2020

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Using large scale molecular dynamics (MD) simulations we study in detail the impact of nanometer droplets of low viscosity on flat substrates versus the wettability of the solid plate. The comparison between the MD simulations and different macroscopic models reveals that most of these models do not correspond to the simulation results at the nanoscale in particular for the maximal contact diameter during the nanodroplet impact (Dmax). We have developed a new model for Dmax which is in agreement with the simulation data and also takes into account the effects of the liquid-solid wettability. We also propose a new scaling for the time required to reach the maximal contact diameter, tmax with respect to the impact velocity which is also in agreement with the observations. With the new model for Dmax plus the scaling found for tmax, we present a master curve collapsing the evolution of the nanometer drop contact diameter during impact for different wettabilities and different impact velocities. We believe our results may help to design better nanoprinters since they provide an estimation of the maximum impact velocities required to obtain a smooth and homogenous coverage of the surfaces without dry spots.

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confidence: 99%

How Wettability Controls Nanoprinting

et al. 2020

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“…Therefore, the delivery of PEG-bisTz solution showed little dependence on the printing direction, in contrast to the printing of highly viscous materials such as photopolymers. 32 These results were reproduced 40 times along various printing directions. We attribute the lack of dependence on printing direction to the low viscosity of PEG-bisTz solution, which is close to 1.0016 mPa•s, similar to that of water.…”

Section: Controlled Assembly Of Peg-bistz During Continuous Delivery Of Solution Along Linesmentioning

confidence: 98%

“…A microfluidic system (FluidFM Bot; Cytosurge AG, Glattbrugg, Switzerland) was integrated with an atomic force microscopy (AFM) assembly, allowing precise position and movement control, and an inverted optical microscope (IX73; Olympus America, Center Valley, PA). 32,33 Solution delivery was carried out using a FluidFM Nanopipette (CYPR/001511; Cytosurge AG) with a 300 nm opening. The cantilever resembled typical AFM silicon probes: 200 μm long, 36 μm wide, and 1.5 μm thick.…”

Section: Integrated Atomic Force Microscopy and Microfluidic Devicementioning

confidence: 99%

“…Typical probesurface contact during delivery is also shown in Figure 1, where the contact force was measured and controlled via similar means as conventional AFM with a deflection configuration. 13,32,35 The square pyramidal tip tilted 11°from the surface normal. The nanopipette probe had a 300 nm diameter pore located at the probe apex connected to a microchannel within the probe body.…”

Section: Controlled Assembly Of Peg-bistz In Individual Ultrasmall Dropletsmentioning

confidence: 99%

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Controlled Molecular Assembly of Tetrazine Derivatives on Surfaces

et al. 2022

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While self-assembly is relatively well-known and widely used to form hierarchical structures and thin film coatings, controlled assembly is less known and utilized. Our prior work has demonstrated the concept of controlled assembly of macromolecules such as star polymers [molecular weight (M w ) ∼383 kDa, hydrodynamic radius R ∼ 13.8 nm] in droplets. This work extends this concept to smaller molecules, in this case, poly(ethylene glycol) bis-tetrazine (PEG-bisTz, M w 8.1 kDa, R ∼1.5 nm). The key to controlled molecular assembly is to first deliver ultrasmall volumes (sub-fL) of solution containing PEG-bisTz to a substrate. The solvent evaporates rapidly due to the minute volume, thus forcing the assembly of solute, whose overall size and dimension are dictated by the initial liquid geometry and size. Using prepatterned surfaces, this work revealed that the initial liquid shape can be further tuned, and we could control the final assembly of solute such as PEG-bisTz molecules. The degree of control was demonstrated by varying the micropatterns and delivery conditions. This work demonstrated the validity of controlled assembly for PEG-bisTz and enables three-dimensional (3D) nanoprinting of functional materials. The technology has promising applications in nanophotonics, nanoelectronics, nanocomposite materials, and tissue engineering.

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“…Microinjection of cells [185]. It can be used for printing of 2D surface patterns with various formations [186] or for precisely controlled template-free 3D micro-and nanoprinting [187], [188]. Micropatterning of living mammalian cells on carboxymethyl-dextran (CMD) hydrogel layers was presented using the FluidFM BOT technology [182].…”

Section: F Main Applicationsmentioning

confidence: 99%

A practical review on the measurement tools for cellular adhesion force

Ungai-Salánki

Péter

Gerecsei

et al. 2019

Advances in Colloid and Interface Science

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Cell-cell and cell-matrix adhesions are fundamental in all multicellular organisms. They play a key role in cellular growth, differentiation, pattern formation and migration. Cell-cell adhesion is substantial in the immune response, pathogen-host interactions, and tumor development. The success of tissue engineering and stem cell implantations strongly depends on the fine control of live cell adhesion on the surface of natural or biomimetic scaffolds. Therefore, the quantitative and precise measurement of the adhesion strength of living cells is critical, not only in basic research but in modern technologies, too. Several techniques have been developed or are under development to quantify cell adhesion. All of them have their pros and cons, which has to be carefully considered before the experiments and interpretation of the recorded data. Current review provides a guide to choose the appropriate technique to answer a specific biological question or to complete a biomedical test by measuring cell adhesion.

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Three-Dimensional Nanoprinting via Direct Delivery

Cited by 43 publications

References 47 publications

How Wettability Controls Nanoprinting

How Wettability Controls Nanoprinting

Controlled Molecular Assembly of Tetrazine Derivatives on Surfaces

A practical review on the measurement tools for cellular adhesion force

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