Three-dimensional nitrogen-doped graphene porous hydrogel fabricated biosensing platform with enhanced photoelectrochemical performance

Hao, Nan; Zhang, Xuan; Zhou, Zhou; Qian, Jing; Liu, Qian; Chen, Saibo; Zhang, Ying; Wang, Kun

doi:10.1016/j.snb.2017.05.003

Cited by 56 publications

(21 citation statements)

References 38 publications

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“…Owing to its practicality, simplicity, and low cost, colorimetric biosensing has drawn increasing concerns . Conversion of target analytes into color changes emerges as a key challenge for colorimetric biosensing . Colorimetric biosensing does not need complicated and costly apparatus, and can be used in point‐of‐care diagnosis and on‐site analysis since the color changes can be read by the unaided eye .…”

Section: Introductionmentioning

confidence: 99%

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Liu

Huang

Qin

et al. 2019

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167

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Diabetes is a dominating health issue with 425 million people suffering from the disease worldwide and 4 million deaths each year. To avoid further complications, the diabetic patient blood glucose level should be strictly monitored despite there being no cure for diabetes. Colorimetric biosensing has attracted significant attention because of its low cost, simplicity, and practicality. Recently, some nanomaterials have been found that possess unexpected peroxidase‐like activity, and great advances have been made in fabricating colorimetric glucose biosensors based on the peroxidase‐like activity of these nanomaterials using glucose oxidase. Compared with natural horseradish peroxidase, the nanomaterials exhibit flexibility in structure design and composition, and have easy separation and storage, high stability, simple preparation, and tunable catalytic activity. To highlight the significant progress in the field of nanomaterial‐based peroxidase‐like activity, this work discusses the various smart nanomaterials that mimic horseradish peroxidase and its mechanism and development history, and the applications in colorimetric glucose biosensors. Different approaches for tunable peroxidase‐like activity of nanomaterials are summarized, such as size, morphology, and shape; surface modification and coating; and metal doping and alloy. Finally, the conclusion and challenges facing peroxidase‐like activity of nanomaterials and future directions are discussed.

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Section: Introductionmentioning

confidence: 99%

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Liu

Huang

Qin

et al. 2019

Small

167

View full text Add to dashboard Cite

show abstract

“…Complexation of organic and inorganic semiconductors are used to overcome the low charge conductivity, narrow absorption spectrum, and strongly bound excitons that are encountered in organic semiconductors (Malliaras, 2001; Coropceanu et al, 2007). This class of transducers typically demonstrates improved PEC response and physical and chemical properties compared to their purely organic or inorganic counterparts (Zhao et al, 2016; Hao et al, 2017a). This type of complexation was demonstrated using TiO 2 mesocrystals (inorganic semiconductor) sensitized with polyethylenimine (organic polymer) (Dai et al, 2017).…”

Section: Photoactive Species For Pec Biosensorsmentioning

confidence: 99%

Affinity-Based Detection of Biomolecules Using Photo-Electrochemical Readout

et al. 2019

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Detection and quantification of biologically-relevant analytes using handheld platforms are important for point-of-care diagnostics, real-time health monitoring, and treatment monitoring. Among the various signal transduction methods used in portable biosensors, photoelectrochemcial (PEC) readout has emerged as a promising approach due to its low limit-of-detection and high sensitivity. For this readout method to be applicable to analyzing native samples, performance requirements beyond sensitivity such as specificity, stability, and ease of operation are critical. These performance requirements are governed by the properties of the photoactive materials and signal transduction mechanisms that are used in PEC biosensing. In this review, we categorize PEC biosensors into five areas based on their signal transduction strategy: (a) introduction of photoactive species, (b) generation of electron/hole donors, (c) use of steric hinderance, (d) in situ induction of light, and (e) resonance energy transfer. We discuss the combination of strengths and weaknesses that these signal transduction systems and their material building blocks offer by reviewing the recent progress in this area. Developing the appropriate PEC biosensor starts with defining the application case followed by choosing the materials and signal transduction strategies that meet the application-based specifications.

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“…In order to determine comprehensive design guidelines for more advanced PEC sensors, the previous review categorized recent PEC biosensor examples into three signaling principles [ 53 ], i.e., reactant determinants, electron transfer, and energy transfer. To further increase the photocurrent, many nanomaterials and nanostructures were incorporated into the construction of PEC biosensors to accelerate charge transfer [ 38 , 51 , 54 , 55 , 56 ] and increase the accessible surface [ 57 ].…”

Section: Biosensors For Protein Immunoassaysmentioning

confidence: 99%

Construction and Potential Applications of Biosensors for Proteins in Clinical Laboratory Diagnosis

Jiang

2017

Sensors

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Biosensors for proteins have shown attractive advantages compared to traditional techniques in clinical laboratory diagnosis. In virtue of modern fabrication modes and detection techniques, various immunosensing platforms have been reported on basis of the specific recognition between antigen-antibody pairs. In addition to profit from the development of nanotechnology and molecular biology, diverse fabrication and signal amplification strategies have been designed for detection of protein antigens, which has led to great achievements in fast quantitative and simultaneous testing with extremely high sensitivity and specificity. Besides antigens, determination of antibodies also possesses great significance for clinical laboratory diagnosis. In this review, we will categorize recent immunosensors for proteins by different detection techniques. The basic conception of detection techniques, sensing mechanisms, and the relevant signal amplification strategies are introduced. Since antibodies and antigens have an equal position to each other in immunosensing, all biosensing strategies for antigens can be extended to antibodies under appropriate optimizations. Biosensors for antibodies are summarized, focusing on potential applications in clinical laboratory diagnosis, such as a series of biomarkers for infectious diseases and autoimmune diseases, and an evaluation of vaccine immunity. The excellent performances of these biosensors provide a prospective space for future antibody-detection-based disease serodiagnosis.

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Three-dimensional nitrogen-doped graphene porous hydrogel fabricated biosensing platform with enhanced photoelectrochemical performance

Cited by 56 publications

References 38 publications

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Peroxidase‐Like Activity of Smart Nanomaterials and Their Advanced Application in Colorimetric Glucose Biosensors

Affinity-Based Detection of Biomolecules Using Photo-Electrochemical Readout

Construction and Potential Applications of Biosensors for Proteins in Clinical Laboratory Diagnosis

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