Three-dimensional numerical simulations of flow through a stenosed coronary bypass

Bertolotti, Christine; Deplano, Valérie

doi:10.1016/s0021-9290(00)00012-9

Cited by 69 publications

(52 citation statements)

References 22 publications

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“…It is well known that hemodynamics are sensitive to geometric factors [25][26][27]. The anastomosis configuration of the CABG is critical, and affects both decision making and outcome of bypass grafting.…”

Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Physiological Blood Flow in 2-way Coronary Artery Bypass Grafts

Qiao

Liu

Li³

et al. 2005

J Biol Phys

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Abstract. The Coronary Artery Bypass Graft (CABG) yields excellent results and remains the modern standard of care for treatment of occlusive disease in the cardiovascular system. However, the development of anastomotic Intimal Hyperplasia (IH) and restenosis can compromise the mediumand-long term effects of the CABG. This problem can be correlated with the geometric configuration and hemodynamics of the bypass graft. A novel geometric configuration was proposed for the CABG with two symmetrically implanted grafts for the purpose of improving the hemodynamics. Physiological blood flows in two models of bypass grafts were simulated using numerical methods. One model was for the conventional bypass configuration with a single graft (1-way model); the other model was for the proposed bypass configuration with two grafts (2-way model). The temporal and spatial distributions of hemodynamics, such as flow patterns and Wall Shear Stress (WSS) in the vicinity of the distal anastomoses, were analyzed and compared. Calculation results showed that the 2-way model possessed favorable hemodynamics with uniform longitudinal flow patterns and WSS distributions, which could decrease the probability of restenosis and improve the effect of the surgical treatment. Concerning the limitations of the 2-way bypass grafts, it is necessary to perform animal experiments to verify the viability of this novel idea for the CABG.

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Section: Introductionmentioning

confidence: 99%

Numerical Simulation of Physiological Blood Flow in 2-way Coronary Artery Bypass Grafts

Qiao

Liu

Li³

et al. 2005

J Biol Phys

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“…Fig. 9): As mentioned in the steady case (BERTOLOTTI and DEPLANO, 2000), the occluded geometry overestimates the WSS value at the toe. According to the recirculating areas analysis (Section 3.1.2), the end of the first deceleration (t 2 s) is the only time when the WSS value is negative at the toe.…”

Section: Variations Along Line C (Fig 8)mentioning

confidence: 50%

“…One of our preliminary studies under steady conditions (BERTOLOTTI and DEPLANO, 2000) has shown the stenosis influence on the flow patterns in the anastomosis. Therefore the aim of this work is to examine the three-dimensional flow structures that occur in the vicinity of the anastomosis under physiological conditions.…”

Section: Introductionmentioning

confidence: 95%

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Numerical simulations of unsteady flows in a stenosed coronary bypass graft

Deplano

Bertolotti

Boiron

2001

Med. Biol. Eng. Comput.

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Using the finite element method, physiological blood flows through a three-dimensional model of a coronary graft are numerically analysed. The model includes a stenosis shape in the host artery upstream from the anastomosis. Recirculating areas, secondary flows, wall shear stress (WSS) and spatial wall shear stress gradients (WSSGs) are studied for different flow repartitions and at different times in the cycle. The temporal and spatial evolutions of the recirculating areas downstream from the stenosis, their interactions with the flow issued from the graft and their associated WSSs highlight that the presence of the stenosis in the recipient artery is essential for prediction of the evolution of a grafting at the beginning of its implantation. The areas downstream from the stenosis expansion, non-existent for a host artery without stenosis, are submitted to low and oscillating WSS between -0.5 and 0 Nm(-2). The stagnation point on the recipient artery floor is subjected to high positive and negative WSSGnd values, and its location is dependent on the residual flow through the stenosis.

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“…This can be achieved by use of numerical methods. However, most of the numerical studies in this area are based on rigid, idealised (Steinman et al, 2000;Bertolotti et al, 2000) or patient specific (Steinman et al, 2002;Myers et al, 2001), arterial geometries, were the interaction between the flowing blood and the deforming arterial wall is not taken into account. Though much attention is given to the complex flow pattern around atherosclerosis susceptible regions, the deformation of the blood vessel during each contraction and expansion of the heart is ignored.…”

Section: Introductionmentioning

confidence: 99%

Validation of a fluid–structure interaction numerical model for predicting flow transients in arteries

Kanyanta

Ivanković

Karač

2009

Journal of Biomechanics

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Three-dimensional numerical simulations of flow through a stenosed coronary bypass

Cited by 69 publications

References 22 publications

Numerical Simulation of Physiological Blood Flow in 2-way Coronary Artery Bypass Grafts

Numerical Simulation of Physiological Blood Flow in 2-way Coronary Artery Bypass Grafts

Numerical simulations of unsteady flows in a stenosed coronary bypass graft

Validation of a fluid–structure interaction numerical model for predicting flow transients in arteries

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