2014
DOI: 10.1117/1.jbo.19.7.076006
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Three-dimensional optical coherence elastography by phase-sensitive comparison of C-scans

Abstract: We present an acquisition method for optical coherence elastography (OCE) that enables acquisition of three-dimensional elastograms in 5 s, an order of magnitude faster than previously reported. In this method, based on compression elastography, the mechanical load applied to the sample is altered between acquisitions of consecutive optical coherence tomography volume scans (C-scans). The voxel-by-voxel phase difference between the volumes is used to determine the axial displacement and determining the gradien… Show more

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Cited by 28 publications
(20 citation statements)
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“…As the Ascan frequency increases, for a set sampling density, so will the B-scan frequency and the actuator loading frequency. To ensure tissue loading remains quasi-static at higher imaging speeds, it may be necessary to calculate phase difference between volumes, as described in a previous study [40].…”
Section: Discussionmentioning
confidence: 99%
“…As the Ascan frequency increases, for a set sampling density, so will the B-scan frequency and the actuator loading frequency. To ensure tissue loading remains quasi-static at higher imaging speeds, it may be necessary to calculate phase difference between volumes, as described in a previous study [40].…”
Section: Discussionmentioning
confidence: 99%
“…With the OCME system reported here, 10 Â 10 mm en face images were acquired in approximately 16 minutes. Our group has recently demonstrated higher speed acquisition, enabling 10 Â 10 mm en face images to be acquired in approximately 20 seconds (43). Using this technique, in combination with the mosaicking used in Figs.…”
Section: Discussionmentioning
confidence: 99%
“…Optical coherence elastography (OCE), which utilizes optical methods and has micron-scale resolution, has gained momentum in characterizing subtle changes in tissue mechanical properties during the early stages of diseases [12]. Recently, ultrafast OCE methods have been used to obtain both 2D and 3D volumetric data quickly, and are rapidly progressing toward translational research [1314]. These methods use air puff or compression techniques for tissue excitation.…”
Section: Introductionmentioning
confidence: 99%