Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

Austin, Topun; Gibson, Adam; Branco, Gilberto; Yusof, Rozarina Md.; Arridge, Simon; Meek, Judith; Wyatt, John; Delpy, David T.; Hebden, Jeremy C.

doi:10.1016/j.neuroimage.2006.02.038

Cited by 78 publications

(66 citation statements)

References 27 publications

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“…Although beyond the scope of this study, other reasons for differences between rScO 2 values measured in extremely preterm infants can be manifold. Besides differences in the techniques as stated above, differences in postmenstrual and postnatal age (25)(26)(27)(28) or differences induced by the different locations of the brain under investigation (29) may contribute to differences in rScO 2 . It will be worthwhile and clinically very important to further investigate these issues in relation to cerebral oxygen saturation.…”

Section: Comparing Nirs Devices and Sensorsmentioning

confidence: 99%

Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate

et al. 2013

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Background: Near-infrared spectroscopy (NIRS) is an upcoming clinical method for monitoring regional cerebral oxygen saturation (rScO 2 ) in neonates. There is a growing market offering different devices and sensors. Even though this technique is increasingly clinically applied, little is known about the similarities and/or differences in rScO 2 values between the different devices and sensors. The aim of this study was to compare the rScO 2 values obtained in (preterm) neonates with all available sensors of three frequently used NIRS devices. Methods: Fifty-five neonates admitted to our neonatal intensive care unit (NICU) were included in this study. rScO 2 was simultaneously monitored bilaterally with two different NIRS sensors (left and right frontoparietal) for at least 1 h. Then, the sensors were switched, and measurements were collected for at least another hour. results: We detected a rather close correlation between all investigated sensors from the three different NIRS devices, but absolute rScO 2 values showed substantial differences: BlandAltman analysis showed average differences from 10 to 15%. conclusion: Although the rScO 2 values correlated well between different NIRS sensors, sometimes there were substantial differences between the absolute rScO 2 values, which may complicate clinical application.

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Section: Comparing Nirs Devices and Sensorsmentioning

confidence: 99%

Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate

et al. 2013

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“…It is worth mentioning that European research groups located in academic or public research centers have designed and built most of the existing TD fNIRS systems effectively employed in the clinics. In particular the most active in the field are the research groups at Physikalisch-Technische Bundesanstalt, Berlin, Germany [9][10][11][12][13][14][15], at the Institute of Biocybernetics and Biomedical Engineering, Warsaw, Poland [16][17][18], and at the the Department of Medical Physics and Bioengineering, University College London [19][20][21][22][23]. In the US we can mention the group at the Massachusetts General Hospital, Athinoula A. Martinos Center, Charlestown, Massachusetts [6,[24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Re¹,

Contini²,

Turola³

et al. 2013

Biomed. Opt. Express

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Abstract:We have designed a compact dual wavelength (687 nm, 826 nm) multi-channel (16 sources, 8 detectors) medical device for muscle and brain imaging based on time domain functional near infrared spectroscopy. The system employs the wavelength space multiplexing approach to reduce wavelength cross-talk and increase signal-to-noise ratio. System performances have been tested on homogeneous and heterogeneous tissue phantoms following specifically designed protocols for photon migration instruments. Preliminary in vivo measurements have been performed to validate the instrument capability to monitor hemodynamic parameters changes in the arm muscle during arterial occlusion and in the adult head during a motor task experiment. ©2013 Optical Society of America

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“…DOT is capable of measuring the intrinsic absorption and scattering in diffuse media using Near Infrared (NIR) light (wavelengths between 650 and 1000 nm), which are then used to derive spatially resolved maps of tissue chromophore concentrations such as oxygenated and deoxygenated haemoglobin. DOT has been applied to monitor tissue metabolic state [2], breast cancer diagnosis [3], imaging functional activity in the human brain [4][5][6] and neonatal brain monitoring [7][8][9]. While most hemodynamic-based neuroimaging research studies in adult subjects are typically performed using functional magnetic resonance imaging (fMRI), its relative high cost, fixed scanner locations and physical constraints during imaging, limit fMRI's translation as a bedside clinical tool [10].…”

Section: Introductionmentioning

confidence: 99%

Quantitative evaluation of atlas-based high-density diffuse optical tomography for imaging of the human visual cortex

Wu¹,

Eggebrecht²,

Ferradal³

et al. 2014

Biomed. Opt. Express

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Image recovery in diffuse optical tomography (DOT) of the human brain often relies on accurate models of light propagation within the head. In the absence of subject specific models for image reconstruction, the use of atlas based models are showing strong promise. Although there exists some understanding in the use of some limited rigid model registrations in DOT, there has been a lack of a detailed analysis between errors in geometrical accuracy, light propagation in tissue and subsequent errors in dynamic imaging of recovered focal activations in the brain. In this work 11 different rigid registration algorithms, across 24 simulated subjects, are evaluated for DOT studies in the visual cortex. Although there exists a strong correlation (R 2 = 0.97) between geometrical surface error and internal light propagation errors, the overall variation is minimal when analysing recovered focal activations in the visual cortex. While a subject specific mesh gives the best results with a 1.2 mm average location error, no single algorithm provides errors greater than 4.5 mm. This work demonstrates that the use of rigid algorithms for atlas based imaging is a promising route when subject specific models are not available.

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Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

Cited by 78 publications

References 27 publications

Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate

Comparing near-infrared spectroscopy devices and their sensors for monitoring regional cerebral oxygen saturation in the neonate

Multi-channel medical device for time domain functional near infrared spectroscopy based on wavelength space multiplexing

Quantitative evaluation of atlas-based high-density diffuse optical tomography for imaging of the human visual cortex

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