Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens

Dongen, Yvette C. van; Mailly, Philippe; Thierry, Anne‐Marie; Groenewegen, Henk J.; Deniau, Jean-Michel

doi:10.1007/s00429-008-0173-5

Cited by 22 publications

(20 citation statements)

References 61 publications

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“…5D–F, 6D–G). In this point of view, neurons of the lateral septum, or transitional forms sharing properties of both structures, occupy the rdAcbSh and the demonstrated interconnections between the two structures reflect accordingly displaced intrinsic connections known to characterize both lateral septum (Jakab and Leranth, 1995) and Acb (Heimer et al, 1991b; van Dongen et al, 2005, 2008). Insofar as the lateral septum itself projects strongly to the lateral preoptic area (Raisman, 1966; Berk and Finkelstein, 1981; Staiger and Wouterlood, 1990; Staiger and Nuernberger, 1991; Risold and Swanson, 1997; Fig.…”

Section: Discussionmentioning

confidence: 89%

On lateral septum‐like characteristics of outputs from the accumbal hedonic “hotspot” of Peciña and Berridge with commentary on the transitional nature of basal forebrain “boundaries”

Zahm

Parsley

Schwartz

et al. 2012

J of Comparative Neurology

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Peciña and Berridge (2005; J Neurosci 25:11777–11786) observed that an injection of the μ-opioid receptor agonist DAMGO (D-ala2-N-Me-Phe4-Glycol5-enkephalin) into the rostrodorsal part of the accumbens shell (rdAcbSh) enhances expression of hedonic “liking” responses to the taste of an appetitive sucrose solution. Insofar as the connections of this hedonic “hotspot” were not singled out for special attention in the earlier neuroanatomical literature, we undertook to examine them. We observed that the patterns of inputs and outputs of the rdAcbSh are not qualitatively different from those of the rest of the Acb, except that outputs from the rdAcbSh to the lateral preoptic area and anterior and lateral hypothalamic areas are anomalously robust and overlap extensively with those of the lateral septum. We also detected reciprocal interconnections between the rdAcbSh and lateral septum. Whether and how these connections subserve hedonic impact remains to be learned, but these observations lead us to hypothesize that the rdAcbSh represents a basal forebrain transition area, in the sense that it is invaded by neurons of the lateral septum, or possibly transitional neuronal forms sharing properties of both structures. We note that the proposed transition zone between lateral septum and rdAcbSh would be but one of many in the basal forebrain and conclude by reiterating the longstanding argument that the transitional nature of such boundary areas has functional importance, of which the precise nature will remain elusive until the neurophysiological and neuropharmacological implications of such zones of transition are more generally acknowledged and better addressed.

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Section: Discussionmentioning

confidence: 89%

On lateral septum‐like characteristics of outputs from the accumbal hedonic “hotspot” of Peciña and Berridge with commentary on the transitional nature of basal forebrain “boundaries”

Zahm

Parsley

Schwartz

et al. 2012

J of Comparative Neurology

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“…For the NAc, a simple patch–matrix organization has been difficult to define, and most authors agree that the compartmental segregation of cells and input–output channels in this region is highly complex (Voorn et al , 1989; Martin et al , 1991; Zahm and Brog, 1992; Jongen-Rêlo et al , 1993; Meredith et al , 1996; van Dongen et al , 2008). …”

Section: Nucleus Accumbensmentioning

confidence: 99%

Cortico-Basal Ganglia Reward Network: Microcircuitry

Sesack

Grace

2009

Neuropsychopharmacol

859

817

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Many of the brain's reward systems converge on the nucleus accumbens, a region richly innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry necessary for selecting adaptive motivated behaviors. The ventral subiculum of the hippocampus provides contextual and spatial information, the basolateral amygdala conveys affective influence, and the prefrontal cortex provides an integrative impact on goal-directed behavior. The balance of these afferents is under the modulatory influence of dopamine neurons in the ventral tegmental area. This midbrain region receives its own complex mix of excitatory and inhibitory inputs, some of which have only recently been identified. Such afferent regulation positions the dopamine system to bias goal-directed behavior based on internal drives and environmental contingencies. Conditions that result in reward promote phasic dopamine release, which serves to maintain ongoing behavior by selectively potentiating ventral subicular drive to the accumbens. Behaviors that fail to produce an expected reward decrease dopamine transmission, which favors prefrontal cortical-driven switching to new behavioral strategies. As such, the limbic reward system is designed to optimize action plans for maximizing reward outcomes. This system can be commandeered by drugs of abuse or psychiatric disorders, resulting in inappropriate behaviors that sustain failed reward strategies. A fuller appreciation of the circuitry interconnecting the nucleus accumbens and ventral tegmental area should serve to advance discovery of new treatment options for these conditions.

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“…Further, such regions are also dissociable by pallidal projection outputs, notably the core predominantly projects to the substantia nigra (SN) while the shell targets the VTA (26, 33, 37–39). However, core and shell regions may also have important intra-structural connections; afferents from the core to the shell (but little from shell to core) may be computationally important for allowing diverse limbic inputs to be integrated into a whole for later output (40–41). These differences in connectivity, strongly suggest that core and shell are differentially engaged in the control of motivational behavior.…”

Section: Anatomy Of the Dopamine System: General Overviewmentioning

confidence: 99%

“…Even within core and shell subregions, cellular organization within the NAc is compartmentalized (46), with a patch-matrix organization similar to that found in the dorsal striatum. Indeed, van Dongen and colleagues report that MSN dendritic arbors are largely contained within compartments, but also strongly respect core and shell boundaries by asymmetrically sending fibers in opposite directions at the core-shell border (41). Thus, processing and dopaminergic influence in the NAc are likely differentiated at the regional (i.e., core and shell) and microcircuit (neural ensemble) level.…”

Section: Anatomy Of the Dopamine System: General Overviewmentioning

confidence: 99%

Rapid dopamine dynamics in the accumbens core and shell Learning and action

Sugam²,

et al. 2013

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The catecholamine dopamine (DA) has been implicated in a host of neural processes as diverse as schizophrenia, parkinsonism and reward encoding. Importantly, these distinct features of DA function are due in large part to separate neural circuits involving connections arising from different DA-releasing nuclei and projections to separate afferent targets. Emerging data has suggested that this same principle of separate neural circuits may be applicable within structural subregions, such as the core and shell of the nucleus accumbens (NAc). Further, DA may act selectively on smaller ensembles of cells (or, microcircuits) via differential DA receptor density and distinct inputs and outputs of the microcircuits, thus enabling new learning about Pavlovian cues, instrumental responses, subjective reward processing and decision-making. In this review, by taking advantage of studies using subsecond voltammetric techniques in behaving animals to study how rapid changes in DA levels affect behavior, we examine the spatial and temporal features of DA release and how it relates to both normal learning and similarities to pathological learning in the form of addiction.

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Three-dimensional organization of dendrites and local axon collaterals of shell and core medium-sized spiny projection neurons of the rat nucleus accumbens

Cited by 22 publications

References 61 publications

On lateral septum‐like characteristics of outputs from the accumbal hedonic “hotspot” of Peciña and Berridge with commentary on the transitional nature of basal forebrain “boundaries”

On lateral septum‐like characteristics of outputs from the accumbal hedonic “hotspot” of Peciña and Berridge with commentary on the transitional nature of basal forebrain “boundaries”

Cortico-Basal Ganglia Reward Network: Microcircuitry

Rapid dopamine dynamics in the accumbens core and shell Learning and action

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