Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers

Fouladian, Paris; Kohlhagen, Jarrod; Arafat, Mohammad; Afinjuomo, Franklin; Workman, Nathan; Abuhelwa, Ahmad Y.; Song, Yunmei; Garg, Sanjay; Blencowe, Anton

doi:10.1039/d0bm01355b

Cited by 26 publications

(10 citation statements)

References 58 publications

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“…The XRD pattern of pure 5-FU had numerous sharp peaks at 2θ angles of 18.5110°, 20.5291°, 22.8284°, 27.1278° and 30.8148° as shown in fig. 3 indicating the crystalline state of the drug [32,33].…”

Section: Thermal Behavior Xrd and Ftir Of 5-fu And Lipidsmentioning

confidence: 99%

Pre-Formulation Study on 5-Fluorouracil and Certain Lipids for Solid Lipid Nanoparticles Preparation

et al. 2022

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Objective: The study's objective involved compatibility studies to investigate the possible interactions between 5-fluorouracil (5-FU) and four different lipids, and the most appropriate lipid was chosen. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), and Fourier Transform Infrared spectroscopy (FT-IR) are used for the compatibility study between 5-FU and several excipients as cholesterol, compritol®, stearic acid, and glycerol monostearate (GMS). Methods: The physical mixture between 5-FU and each lipid was made by mixing of a certain amount of drug with the same amount of lipid. Drug lipid blended mixtures were made by solvent evaporation casting method. 5-FU alone, physical mixture and blended mixture were measured using Differential scanning calorimetry (DSC) to investigate melting peak of drug and effect of each lipid on this melting point, X-ray diffraction (XRD) to observe the crystalline or amorphous state of drug and Fourier Transform Infrared (FT-IR) to determine any chemical interaction between drug and these lipids by observing any shift happened to characteristic peaks related to the drug. Results: 5-FU Tm (280.04 °C) peak appeared in drug-lipid physical mixtures with minor changes in position while this peak disappeared in 5-FU-compritol® and 5-FU-cholesterol blended mixture, indicating that the drug is molecular dispersed. XRD result showed that the crystalline structure of 5-FU was present in physical mixtures with four lipids, while in the 5-FU-compritol® blended mixture, the crystalline state of the drug was disappeared, confirming the DSC result. The FT-IR spectrum of the 5-FU-physical mixtures with four lipids showed that all characteristic peaks of the drug appeared with minor changes. In the case of 5-FU-blended mixtures with mentioned lipids, no chemical interaction occurred between the drug and mentioned lipids except in the drug-stearic acid blended mixture, the N-H peak at 3136.25 cm-1 was disappeared due to amide ester formation. Conclusion: The most appropriate lipids suitable for the preparation of 5-FU solid lipid nanoparticles were GMS and cholesterol.

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Section: Thermal Behavior Xrd and Ftir Of 5-fu And Lipidsmentioning

confidence: 99%

Pre-Formulation Study on 5-Fluorouracil and Certain Lipids for Solid Lipid Nanoparticles Preparation

et al. 2022

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“…Since the inclined and bent states are reversibly switched, the shifted fibers can be endoscopically introduced, subsequently bent, and assembled into tubular stents inside the targeted tissue. Thanks to their high flexibility in scale, these transformable stents could potentially be used as the inner stent rings for bile ducts, [ 17 ] tracheae, [ 18 ] esophagi, [ 19 ] and gastrointestinal tracts, [ 20 ] and as outer rings to cover atrioventricular rings and prevent hypertrophy. [ 21 ]…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Implants Composed of Nanjing Tamasudare‐Inspired Flexible Shape Transformers

Teshima

Hiendlmeier

Terkan

et al. 2021

Adv Materials Technologies

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Minimizing damage during the insertion of stents or other medical devices is critical for rapid and successful recovery. Since the delivery passages are often narrower than the size of the delivered object, a high deformability of the implanted devices is paramount to achieve a smooth insertion into the target tissue. In this study, a novel design of 3D‐printable and highly deformable structures inspired by Nanjing Tamasudare is proposed. These structures rapidly change dimensionality from flat to linear, elongated shapes. A series of single units that each comprises two interconnected rods and attaching loops are directly 3D‐printed without classical assembly or fabrication. Multiple units are connected together but remain individually movable and deformable. The smooth changes of the unit assembly, including shifting, bending, and inclination, allow to transform the structure from an initially condensed state to various types of target shapes. To verify the transformation capabilities, smooth insertion of the 3D‐printed structure in a mock‐up vessel through a small opening in an elongated state is demonstrated. After insertion, the units are reassembled to a stent‐like structure within the vessel. The authors believe that this 3D‐printable and highly transformable design is widely applicable for insertion operations of implantable devices or electronics.

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“…We envisage that the utility of 3D printing will expand, enabling the manufacturing of complex drug products, for example, personalized implantable or wearable systems with controllable drug dissolution rates that exploit the benefits conferred by 3D printing materials. To maximize their potential, additive manufacturing can be associated with a 3D scanning system that extracts details of a patient’s anatomy to make a customized tool that is specific to the patient such as drug-loaded patches that fit specific patient anatomies. − However, current methods are inadequate in terms of standardization of approaches and materials, hampering the advancement of scalable and consistent 3D-printed drug delivery tools for use in healthcare industries. ,,, This was demonstrated in 3D-printed individualized mouthguards that were manufactured based on personalized intraoral scans of dentition impressions with the ability to deliver clobetasol propionate in the oral cavity, and their in vitro drug release behavior was evaluated (Figure ). The drug dissolution behavior in humans was assessed from three kinds of mouthguards in varying material composition or design using vanillic acid (food-grade flavorant) instead of clobetasol propionate, where a sustained release profile was observed over the 6 h trial.…”

Section: Three-dimensional Printing (Additive Manufacturing) Techniqu...mentioning

confidence: 99%

Traction of 3D and 4D Printing in the Healthcare Industry: From Drug Delivery and Analysis to Regenerative Medicine

Osouli-Bostanabad

Masalehdan

Kapsa

et al. 2022

ACS Biomater. Sci. Eng.

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printing and 3D bioprinting are promising technologies for a broad range of healthcare applications from frontier regenerative medicine and tissue engineering therapies to pharmaceutical advancements yet must overcome the challenges of biocompatibility and resolution. Through comparison of traditional biofabrication methods with 3D (bio)printing, this review highlights the promise of 3D printing for the production of on-demand, personalized, and complex products that enhance the accessibility, effectiveness, and safety of drug therapies and delivery systems. In addition, this review describes the capacity of 3D bioprinting to fabricate patient-specific tissues and living cell systems (e.g., vascular networks, organs, muscles, and skeletal systems) as well as its applications in the delivery of cells and genes, microfluidics, and organ-on-chip constructs. This review summarizes how tailoring selected parameters (i.e., accurately selecting the appropriate printing method, materials, and printing parameters based on the desired application and behavior) can better facilitate the development of optimized 3D-printed products and how dynamic 4D-printed strategies (printing materials designed to change with time or stimulus) may be deployed to overcome many of the inherent limitations of conventional 3D-printed technologies. Comprehensive insights into a critical perspective of the future of 4D bioprinting, crucial requirements for 4D printing including the programmability of a material, multimaterial printing methods, and precise designs for meticulous transformations or even clinical applications are also given.

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Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers

Abstract: 3D printing is introduced as rapid and facile approach to prepare personalized drug-eluting stents for the treatment of oesophageal cancers.

Cited by 26 publications

References 58 publications

Pre-Formulation Study on 5-Fluorouracil and Certain Lipids for Solid Lipid Nanoparticles Preparation

Pre-Formulation Study on 5-Fluorouracil and Certain Lipids for Solid Lipid Nanoparticles Preparation

3D Printing of Implants Composed of Nanjing Tamasudare‐Inspired Flexible Shape Transformers

Traction of 3D and 4D Printing in the Healthcare Industry: From Drug Delivery and Analysis to Regenerative Medicine

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