Three-Dimensional Printing-based Reconstruction of a Maxillary Bone Defect in a Dog Following Tumor Removal

Kim, Se Eun; Shim, Kyung Mi; Jang, Kwangsik; Shim, Jin‐Hyung; Kang, Seong Soo

doi:10.21873/invivo.11205

Cited by 23 publications

(28 citation statements)

References 15 publications

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“…Extruded PCL/β-TCP scaffolds were used to reconstruct maxillofacial defects in dogs [ 146 ]. Scaffolds had a 500 × 100 μm pore size and 63% porosity.…”

Section: Extrusion Printingmentioning

confidence: 99%

Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation

Rider

Kačarević

Alkildani

et al. 2018

IJMS

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Three-dimensional (3D) printing has become an important tool in the field of tissue engineering and its further development will lead to completely new clinical possibilities. The ability to create tissue scaffolds with controllable characteristics, such as internal architecture, porosity, and interconnectivity make it highly desirable in comparison to conventional techniques, which lack a defined structure and repeatability between scaffolds. Furthermore, 3D printing allows for the production of scaffolds with patient-specific dimensions using computer-aided design. The availability of commercially available 3D printed permanent implants is on the rise; however, there are yet to be any commercially available biodegradable/bioresorbable devices. This review will compare the main 3D printing techniques of: stereolithography; selective laser sintering; powder bed inkjet printing and extrusion printing; for the fabrication of biodegradable/bioresorbable bone tissue scaffolds; and, discuss their potential for dental applications, specifically augmentation of the alveolar ridge.

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“…Extruded PCL/β-TCP scaffolds were used to reconstruct maxillofacial defects in dogs [ 146 ]. Scaffolds had a 500 × 100 μm pore size and 63% porosity.…”

Section: Extrusion Printingmentioning

confidence: 99%

Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation

Rider

Kačarević

Alkildani

et al. 2018

IJMS

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“…This device was designed to provide suitable mechanical properties and a 3D stem cell culture environment. The advantages of our 3D-printed scaffold are the accurate outline dimensions and complex internal morphology of the mandibular ramus, which might meet with the patients' individual requirements [ 14 ]. Matrigel has been chosen in our study as the extracellular matrix (ECM) for BMSCs.…”

Section: Introductionmentioning

confidence: 99%

3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds

Liu

et al. 2018

Stem Cells International

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Mandibular bone defect reconstruction is an urgent challenge due to the requirements for daily eating and facial aesthetics. Three-dimensional- (3D-) printed titanium (Ti) scaffolds could provide patient-specific implants for bone defects. Appropriate load-bearing properties are also required during bone reconstruction, which makes them potential candidates for mandibular bone defect reconstruction implants. However, in clinical practice, the insufficient osteogenesis of the scaffolds needs to be further improved. In this study, we first encapsulated bone marrow-derived mesenchymal stem cells (BMSCs) into Matrigel. Subsequently, the BMSC-containing Matrigels were infiltrated into porous Ti6Al4V scaffolds. The Matrigels in the scaffolds provided a 3D culture environment for the BMSCs, which was important for osteoblast differentiation and new bone formation. Our results showed that rats with a full thickness of critical mandibular defects treated with Matrigel-infiltrated Ti6Al4V scaffolds exhibited better new bone formation than rats with local BMSC injection or Matrigel-treated defects. Our data suggest that Matrigel is able to create a more favorable 3D microenvironment for BMSCs, and Matrigel containing infiltrated BMSCs may be a promising method for enhancing the bone formation properties of 3D-printed Ti6Al4V scaffolds. We suggest that this approach provides an opportunity to further improve the efficiency of stem cell therapy for the treatment of mandibular bone defects.

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“…Kim et al 33 demonstrated a successful reconstruction of maxillary bone in a 12-year-old dog using a printed PCL/β-TCP scaffold. The scaffold was fabricated using micro-extrusion-based 3D bioprinting and demonstrated successful reconstruction 8 months after surgery.…”

Section: Techniquesmentioning

confidence: 99%

“…This case is believed to be the first case of reconstruction using a 3D-printed scaffold in the maxillary bone defect. 33 …”

Section: Techniquesmentioning

confidence: 99%

Bioprinting of tissue engineering scaffolds

Rider¹,

et al. 2018

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Bioprinting is the process of creating three-dimensional structures consisting of biomaterials, cells, and biomolecules. The current additive manufacturing techniques, inkjet-, extrusion-, and laser-based, create hydrogel structures for cellular encapsulation and support. The requirements for each technique, as well as the technical challenges of printing living cells, are discussed and compared. This review encompasses the current research of bioprinting for tissue engineering and its potential for creating tissue-mimicking structures.

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Three-Dimensional Printing-based Reconstruction of a Maxillary Bone Defect in a Dog Following Tumor Removal

Cited by 23 publications

References 15 publications

Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation

Additive Manufacturing for Guided Bone Regeneration: A Perspective for Alveolar Ridge Augmentation

3D Culture of Bone Marrow-Derived Mesenchymal Stem Cells (BMSCs) Could Improve Bone Regeneration in 3D-Printed Porous Ti6Al4V Scaffolds

Bioprinting of tissue engineering scaffolds

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