Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

Water, Jorrit J.; Bohr, Adam; Boetker, Johan; Aho, Johanna; Sandler, Niklas; Nielsen, Hanne Mørck; Rantanen, Jukka

doi:10.1002/jps.24305

Cited by 144 publications

(72 citation statements)

References 29 publications

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“…It has established roots in engineering and many non-medical practices, especially in the automobile industries. Recently its applications in medical devices (31,32), implants (33) 3D printing in its essence is repeated and co-ordinated two-dimensional printing. The main focus in this review is on multi-layer 3D printing whilst single layer printing of flat object is considered less relevant.…”

Section: D Printing Technologiesmentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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The recent introduction of the first FDA approved 3D-printed drug has fuelled interest in 3D printing technology, which is set to revolutionize healthcare. Since its initial use, this rapid prototyping (RP) technology has evolved to such as extent that it is currently being used in a wide range of applications including in tissue engineering, dentistry, construction, automotive and aerospace. However, in the pharmaceutical industry this technology is still in its infancy and its potential yet to be fully explored. This paper presents various 3D printing technologies such as stereolithographic, powder based, selective laser sintering, fused deposition modelling and semi-solid extrusion 3D printing. It also provides a comprehensive review of previous attempts at using 3D printing technologies on the manufacturing dosage forms with a particular focus on oral tablets. Their advantages particularly with adaptability in the pharmaceutical field have been highlighted, including design flexibility and control and manufacture which enables the preparation of dosage forms with complex designs and geometries, multiple actives and tailored release profiles. An insight into the technical challenges facing the different 3D printing technologies such as the formulation and processing parameters is provided. Light is also shed on the different regulatory challenges that need to be overcome for 3D printing to fulfil its real potential in the pharmaceutical industry.

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Section: D Printing Technologiesmentioning

confidence: 99%

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

et al. 2016

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“…It uses an additive or layer-by-layer-based approach to create a complex 3D geometry for a variety of applications. 19,20 Its ability to customize and fabricate complex structures [21][22][23][24][25] has prompted its use in many health care applications, such as for bone and cartilage replacements, customized dental implants, antimicrobial drug-eluting implants, hearing aids, and surgical guides, among others. 3DP also offers the advantages of speed, low cost, availability of a wide range of printing materials, accuracy, and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

Lim

Chia

Kang

et al. 2016

Journal of Pharmaceutical Sciences

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“…The potential of FDM-based 82 3D printers to incorporate drug molecules have already been 83 investigated using commercially available PVA filaments [15][16][17]. 84 Our research group showed the potential of this printing 16,17,19,20]. 94 In this study, a combined approach of manufacturing 3D printed 95 tablet based on FDM 3D printing and Hot Melt Extrusion (HME) is 96 presented.…”

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confidence: 97%

A flexible-dose dispenser for immediate and extended release 3D printed tablets

Pietrzak

Isreb

Alhnan

2015

European Journal of Pharmaceutics and Biopharmaceutics

362

202

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The advances in personalised medicine increased the demand for a fast, accurate and reliable production method of tablets that can be digitally controlled by healthcare staff. A flexible dose tablet system is presented in this study that proved to be suitable for immediate and extended release tablets with a realistic drug loading and an easy-to-swallow tablet design. The method bridges the affordable and digitally controlled Fused Deposition Modelling (FDM) 3D printing with a standard pharmaceutical manufacturing process, Hot Melt Extrusion (HME). The reported method was compatible with three methacrylic polymers (Eudragit RL, RS and E) as well as a cellulose-based one (hydroxypropyl cellulose, HPC SSL). The use of a HME based pharmaceutical filament preserved the linear relationship between the mass and printed volume and was utilized to digitally control the dose via an input from computer software with dose accuracy in the range of 91-95%. Higher resolution printing quality doubled the printing time, but showed a little effect on in vitro release pattern of theophylline and weight accuracy. Physical characterization studies indicated that the majority of the model drug (theophylline) in the 3D printed tablet exists in a crystal form. Owing to the small size, ease of use and the highly adjustable nature of FDM 3D printers, the method holds promise for future individualised treatment.

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Three-Dimensional Printing of Drug-Eluting Implants: Preparation of an Antimicrobial Polylactide Feedstock Material

Cited by 144 publications

References 29 publications

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Emergence of 3D Printed Dosage Forms: Opportunities and Challenges

Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold

A flexible-dose dispenser for immediate and extended release 3D printed tablets

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