Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability

Wu, Chengtie; Luo, Yongxiang; Cuniberti, Gianaurelio; Xiao, Yin; Gelinsky, Michael

doi:10.1016/j.actbio.2011.03.009

Cited by 332 publications

(205 citation statements)

References 33 publications

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“…The compressive strengths are Ceramics International xxx (xxxx) xxx-xxx low, compared with the value obtained in the present work, even those reported for scaffolds with less porosity, with the exception of the strengths reported by Wu et al [38]. This compressive strength improvement in scaffolds prepared using mixed powder technology and the polymer foaming method may be associated with the consolidation of the struts within the structure of the foams, because the particles are better sintered as the sintering temperature increases [10].…”

Section: Ea Aguilar-reyes Et Alcontrasting

confidence: 49%

Processing and in vitro bioactivity of high-strength 45S5 glass-ceramic scaffolds for bone regeneration

Aguilar-Reyes

León‐Patiño

Villicaña-Molina

et al. 2017

Ceramics International

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Vous avez des questions? Nous pouvons vous aider. Pour communiquer directement avec un auteur, consultez la première page de la revue dans laquelle son article a été publié afin de trouver ses coordonnées. Si vous n'arrivez pas à les repérer, communiquez avec nous à PublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. Questions? Contact the NRC Publications Archive team atPublicationsArchive-ArchivesPublications@nrc-cnrc.gc.ca. If you wish to email the authors directly, please see the first page of the publication for their contact information. NRC Publications Archive Archives des publications du CNRCThis publication could be one of several versions: author's original, accepted manuscript or the publisher's version. / La version de cette publication peut être l'une des suivantes : la version prépublication de l'auteur, la version acceptée du manuscrit ou la version de l'éditeur. NRC Publications Record / Notice d'Archives des publications de CNRC:http://nparc.cisti-icist.nrc-cnrc.gc.ca/eng/view/object/?id=90c0c36d-743d-4b59-8cd5-38ea2fcab383 http://nparc.cisti-icist.nrc-cnrc.gc.ca/fra/voir/objet/?id=90c0c36d-743d-4b59-8cd5-38ea2fcab383 ABSTRACTIn this paper, the compressive strength and in vitro bioactivity of sintered 45S5 bioactive glass scaffolds produced by powder technology and polymer foaming were investigated. The sintering temperature of scaffolds was 975°C. The characterization of scaffolds before immersion in SBF was performed by scanning electron microscopy (SEM) and microtomography (μCT). The scaffolds were also tested for compression, and their density and porosity were measured. After immersion, the samples were observed through SEM and analyzed using EDS, X-ray diffraction (XRD), and infrared spectroscopy (FT-IR). Mass variation was also estimated. The glass-ceramic scaffolds showed a 61.44 ± 3.13% interconnected porosity and an average compressive strength of 13.78 ± 2.43 MPa. They also showed the formation of a hydroxyapatite layer after seven days of immersion in SBF, demonstrating that partial crystallization during sintering did not suppress their bioactivity.

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Section: Ea Aguilar-reyes Et Alcontrasting

confidence: 49%

Processing and in vitro bioactivity of high-strength 45S5 glass-ceramic scaffolds for bone regeneration

Aguilar-Reyes

León‐Patiño

Villicaña-Molina

et al. 2017

Ceramics International

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“…On the other hand, because MBGs are glasses they do not exhibit an exact composition and can be substituted with small amounts of extra oxides of cations featuring important biological actions, such as osteogenesis, antibacterial capacity, angiogenesis or cementogenesis [11][12][13]. For this reason, there is a general trend to upgrade properties with some of the well known therapeutical ions because of their biological action [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Glasses in bone regeneration: A multiscale issue

Salinas

Vallet‐Regí

2016

Journal of Non-Crystalline Solids

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Highligths MBGs containing small amounts of Ga, Ce or Zn exhibit high in vitro bioactivity  The bioactive response is preserved after obtaining 3D scaffolds  These scaffolds are optimum candidates for bone tissue engineering applications  MBG scaffold with 4% ZnO exhibit bactericide action against S. Aureus  The effects of the extra ions is sometimes complex and needs to be investigated 2 Abstract 3D scaffolds based in mesoporous bioactive glasses (MBGs) are being widely investigated to use in bone tissue engineering (TE) applications. These scaffolds are often obtained by rapid prototyping (RP) and exhibit an array of interconnected pores in a hierarchy of sizes. The ordered mesopores network (around 4 nm in diameter), is optimal for the adsorption and release of bone inductor biomolecules, and the arrangement of macropores over 100 m facilitates the bone cell ingrowths and angiogenesis. Nevertheless MBGs composition can be varied almost infinitely at the atomic scale by including in the glass network oxides of inorganic elements with a therapeutic action. In this article the synthesis and characterization of MBG scaffolds based on the 80%SiO2-15%CaO-5%P2O5 (in mol-%) glass with substitutions up to 3.5% of Ga2O3 or Ce2O3 or 7.0% of ZnO is revisited. The substituent inclusion and the RP processing slightly decrease the surface area, the pore volume and the mesoporous order as well as their bioactive response in solutions mimicking blood plasma. However, these values still remain useful for bone TE applications. Results exhibiting the bactericide action of MBG scaffolds containing ZnO are also presented. KeywordsMesoporous bioactive glass scaffolds; Ga, Ce and Zn as therapeutical ions; bactericide capability; bone tissue engineering 3

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“…9 However, MBG as a scaffold for bone repair also has drawbacks such as inherent brittleness. 13,14 In contrast, p(N-isopropylacrylamide-co-butyl methylacrylate) (PIB) nanogels is a temperature-sensitive cross-linking polymer and its dispersion exhibits three phase states (swollen gel, flowable sol, and shrunken gel) in accordance with temperature changes. It can be used to treat defects of irregular shapes and deformities as an injectable, thermoresponsive, biocompatible hydrogel for tissue engineering applications which undergoes rapid thermal gelation once the sol form reaches body temperature.…”

Section: Introductionmentioning

confidence: 99%

In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold

Chen¹,

Zhao²,

Geng³

et al. 2015

IJN

Self Cite

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Purpose In the present study, the fabrication of novel p(N-isopropylacrylamide-co-butyl methylacrylate) (PIB) nanogels was combined with boron-containing mesoporous bioactive glass (B-MBG) scaffolds in order to improve the mechanical properties of PIB nanogels alone. Scaffolds were tested for mechanical strength and the ability to promote new bone formation in vivo. Patients and methods To evaluate the potential of each scaffold in bone regeneration, ovariectomized rats were chosen as a study model to determine the ability of PIB nanogels to stimulate bone formation in a complicated anatomical bone defect. PIB nanogels and PIB nanogels/B-MBG composites were respectively implanted into ovariectomized rats with critical-sized femur defects following treatment periods of 2, 4, and 8 weeks post-implantation. Results Results from the present study demonstrate that PIB nanogels/B-MBG composites showed greater improvement in mechanical strength when compared to PIB nanogels alone. In vivo, hematoxylin and eosin staining revealed significantly more newly formed bone in defects containing PIB nanogels/B-MBG composite scaffolds when compared to PIB nanogels alone. Tartrate-resistant acid phosphatase-positive staining demonstrated that both scaffolds were degraded over time and bone remodeling occurred in the surrounding bone defect as early as 4 weeks post-implantation. Conclusion The results from the present study indicate that PIB nanogels are a potential bone tissue engineering biomaterial able to treat defects of irregular shapes and deformities as an injectable, thermoresponsive, biocompatible hydrogel which undergoes rapid thermal gelation once body temperature is reached. Furthermore, its combination with B-MBG scaffolds improves the mechanical properties and ability to promote new bone formation when compared to PIB nanogels alone.

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Three-dimensional printing of hierarchical and tough mesoporous bioactive glass scaffolds with a controllable pore architecture, excellent mechanical strength and mineralization ability

Cited by 332 publications

References 33 publications

Processing and in vitro bioactivity of high-strength 45S5 glass-ceramic scaffolds for bone regeneration

Processing and in vitro bioactivity of high-strength 45S5 glass-ceramic scaffolds for bone regeneration

Glasses in bone regeneration: A multiscale issue

In vivo experimental study on bone regeneration in critical bone defects using PIB nanogels/boron-containing mesoporous bioactive glass composite scaffold

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