Three-Dimensional Printing of Patient-Specific Heart Valves: Separating Facts From Fiction and Myth From Reality

Mufarrih, Syed Hamza; Mahmood, Feroze; Qureshi, Nada Qaisar; Yunus, Rayaan; Quraishi, Ibrahim; Baribeau, Vincent; Sharkey, Aidan; Matyal, Robina; Khabbaz, Kamal R.

doi:10.1053/j.jvca.2021.09.012

Cited by 3 publications

(3 citation statements)

References 92 publications

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“…Of these treatments, cell therapy using 3D bioprinting with patient-specific cells to repair damaged cardiac tissues or to replace end-stage organ failure through tissue engineering is promising [ 48 , 54 ]. It is also theoretically able to bypass the limitations of poor biocompatibility, biofunctionality, and immune rejection as well as the drastic shortage of organ donors [ 55 , 56 , 57 , 58 ].…”

Section: Three-dimensional Bioprinting: Where Are We Now?mentioning

confidence: 99%

Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions

Sun,

Zhao,

Leung

et al. 2023

Biomolecules

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Three-dimensional (3D) printing plays an important role in cardiovascular disease through the use of personalised models that replicate the normal anatomy and its pathology with high accuracy and reliability. While 3D printed heart and vascular models have been shown to improve medical education, preoperative planning and simulation of cardiac procedures, as well as to enhance communication with patients, 3D bioprinting represents a potential advancement of 3D printing technology by allowing the printing of cellular or biological components, functional tissues and organs that can be used in a variety of applications in cardiovascular disease. Recent advances in bioprinting technology have shown the ability to support vascularisation of large-scale constructs with enhanced biocompatibility and structural stability, thus creating opportunities to replace damaged tissues or organs. In this review, we provide an overview of the use of 3D bioprinting in cardiovascular disease with a focus on technologies and applications in cardiac tissues, vascular constructs and grafts, heart valves and myocardium. Limitations and future research directions are highlighted.

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Section: Three-dimensional Bioprinting: Where Are We Now?mentioning

confidence: 99%

Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions

Sun,

Zhao,

Leung

et al. 2023

Biomolecules

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“…AM has been widely used to prepare porous biomaterial implants for guiding tissue reconstruction in recent years. Additively manufactured bioceramic − and bioceramic/organics composites − are universally applied in cardiovascular tissue, , cardiac stents, , and bone regeneration. − Normally, bone regeneration requires the porous bioimplant equipped with good biocompatibility, noncytotoxic, no immune rejection, effective in promoting bone tissue reconstruction, sufficient strength, and supporting cell proliferation growth and adhesion . Therefore, suitable mechanical properties, appropriate structural design, and excellent osteoconductive properties are the basic requirements for additively manufactured porous biomaterial implants. − Among various additively manufactured bioceramic implants, bioinert ceramics represented by zirconia (ZrO 2 ), and bioactive ceramics represented by hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP), and biphasic calcium phosphate (BCP), have shown excellent comprehensive performance and have gradually become the mainstay of bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…18 AM has been widely used to prepare porous biomaterial implants for guiding tissue reconstruction in recent years. Additively manufactured bioceramic 19−22 and bioceramic/organics composites 23−27 are universally applied in cardiovascular tissue, 28,29 cardiac stents, 30,31 and bone regeneration. 32−34 Normally, bone regeneration requires the porous bioimplant equipped with good biocompatibility, noncytotoxic, no immune rejection, effective in promoting bone tissue reconstruction, sufficient strength, and supporting cell proliferation growth and adhesion.…”

Section: Introductionmentioning

confidence: 99%

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives

Zhou

Su²,

et al. 2023

ACS Biomater. Sci. Eng.

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Treating bone defects is highly challenging because they do not heal on their own inside the patients, so implants are needed to assist in the reconstruction of the bone. Bioceramic implants based on additive manufacturing (AM) are currently emerging as promising treatment options for restoration bone engineering. On the one hand, additively manufactured bioceramic implants have excellent mechanical properties and biocompatibility, which are suitable for bone regeneration. On the other hand, the designable structure and adjustable pores of additively manufactured bioceramic implants allow them to promote suitable cell growth and tissue climbing. Herein, this review unfolds to introduce several frequently employed AM technologies for bioceramic implants. After that, advances in commonly used additively manufactured bioceramic implants, including bioinert ceramic implants, bioactive ceramic implants, and bioceramic/organic composite implants, are categorized and summarized. Finally, the future perspectives of additively manufactured bioceramic implants, in terms of mechanical performance improvement, innovative structural design, biological property enhancement, and other functionalization approaches, are proposed and forecasted. This review is believed to provide some fundamental understanding and cutting-edge knowledge for the additive manufacturing of bioceramic implants for restoration bone engineering.

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3D Bioprinting in Cardiovascular Disease: Current Status and Future Directions

Sun¹,

Zhao²,

Leung³

et al. 2023

Preprint

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3D printing is playing an important role in cardiovascular disease by use of personalised models with replication of normal anatomy and pathology with high accuracy and reliability. While 3D printed heart and vascular models are shown to improve medical education, preoperative planning and simulation of cardiac procedures, and enhance communication with patients, 3D bioprinting however, represents a potential advancement of 3D printing technology by printing cellular or biological components, functional tissues and organs that can be used in a variety of applications in cardiovascular disease. Recent advances in bioprinting technology have shown the ability to support vascularisation of large scale constructs with enhanced biocompatibility and structural stability, thus creating opportunities to replace damaged tissues or organs. In this review, we provide an overview of the use of 3D bioprinting in cardiovascular disease with a focus on technologies and applications in cardiac tissues, vascular constructs and grafts, heart valves and myocardium. Limitations and future research directions are highlighted.

show abstract

Three-Dimensional Printing of Patient-Specific Heart Valves: Separating Facts From Fiction and Myth From Reality

Cited by 3 publications

References 92 publications

Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions

Three-Dimensional Bioprinting in Cardiovascular Disease: Current Status and Future Directions

Additive Manufacturing of Bioceramic Implants for Restoration Bone Engineering: Technologies, Advances, and Future Perspectives

3D Bioprinting in Cardiovascular Disease: Current Status and Future Directions

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