Three Dimensional Projection Environment for Molecular Design and Surgical Simulation

Abstract

REPORT DOCUMENTATION PAGEForm Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. (From -To) 29- 07-2009 -28-07-2011 REPORT DATE (DD-MM-YYYY) 28-08-2011 REPORT TYPE Final DATES COVERED SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S)Medical Research and Materiel USAMRMC Materiel Command TATRC Telemedicine & Advanced Fort Detrick SPONSOR/MONITOR'S REPORTTechnology Research Center Maryland 21702-5012 NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for public release; distribution unlimited SUPPLEMENTARY NOTES ABSTRACTWe hypothesized in Aim 1 that docking of three-dimensional (3D) projections of potential target binding agents with 3D projections of macromolecular disease targets visualized on a computer with touch and feel feedback will enable identification of optimal agent designs, and culling of suboptimal agent designs, prior to synthesis. We found that direct measurements of cellular uptake of two different EGF fragments, EGF20-31 and EGF32-48, agreed with the computer predictions of no uptake by EGF20-31, and significant uptake by EGF32-48. This observation is consistent with our first hypothesis. We hypothesized in Aim 2 that 3D FDG PET images of patients superimposed on 3D anatomical images of patients visualized on a large computer display would enable improved preoperative planning, because the FDG PET images revealed specific sites of active disease. We found that a set of 6 experienced surgeons found that the final 3D version was accurate, useful, and worth applying in practice. This observation is consistent with our second hypothesis. SUBJECT TERMScancer, computerized tomography, haptic, hybridization, imaging, molecular dynamics, nuclear medicine, oncogene, pancreatic, positron emission tomography, receptors, surgery, volumetric A. INTRODUCTIONWe hypothesized that our fusion of genetic, visual, and tactile information would improve surgeons' understanding of the extent of disease and will ultimately permit surgeons to better plan operations and to prepare for the actual pathology found. We proposed to combine current medical imaging technologies with genetic imaging to leverage our ability to pr...

Consistent Surgeon Evaluations of Three-Dimensional Rendering of PET/CT Scans of the Abdomen of a Patient with a Ductal Pancreatic Mass

“…These simulations require accurate representation of patient physiology and incorporation of other image sets to improve diagnostic accuracy [21]. Combining multiple modalities into into individual patient 3D presentations is intended to improve the surgeon’s ability to prepare for a procedure [22]. We hypothesized that experienced surgeons could consistently evaluate the usefulness of a 3D visualization of patient CT images co-registered with PET images as a pre-operative assessment tool.…”