Vegetation is an important type of land cover. Long-term, large-scale, and high-precision vegetation monitoring is of great significance for ecological environment investigation and regional sustainable development in protected areas. This paper develops a long-term remote sensing monitoring method for vegetation by calculating the normalized difference vegetation index (NDVI) based on the Google Earth Engine (GEE) cloud platform and Landsat satellite remote sensing images. First, based on Landsat long-term satellite images and GEE, the spatiotemporal distribution map of the NDVI is accurately drawn. Subsequently, the NDVI is accurately classified, and the time trend analysis of the NDVI is conducted based on the NDVI mean trend graphs, transition matrices, etc. Then, combined with Moran’s I, high/low clusters, and other methods, the spatial pattern characteristics of the NDVI are analyzed. Finally, climate factors, terrain factors, and anthropologic factors are considered comprehensively. An analysis of the factors affecting the evolution of the NDVI is performed. Taking Zhoushan Island, China, as an example, an experiment is conducted, and the results reveal that (1) the average NDVI exhibits a decreasing trend from 1985 to 2022, decreasing from 0.53 in 1985 to 0.46 in 2022. (2) Regarding vegetation index transitions, the high NDVI areas (0.6–1) exhibit the most substantial shift toward moderately high NDVI values (0.4–0.6), covering an area of 83.10 km2. (3) There is an obvious spatial agglomeration phenomenon in the NDVI on Zhoushan Island. The high-high NDVI clusters and the significant hot spots are predominantly concentrated in the island’s interior regions, while the low-low NDVI clusters and the significant cold spots are mainly situated along the coastal areas. (4) The DEM, slope, and temperature have a greater influence among the single factors on the spatial pattern distribution of the NDVI in 2015. There are significant differences in the spatial pattern distribution of the NDVI between the temperature and DEM, temperature and slope, DEM and precipitation, slope and precipitation, aspect and population, and aspect and gross domestic product (GDP). The DEM and slope, DEM and temperature, and DEM and population are three sets of factors with a strong influence on spatial pattern interaction. This study provides data support for the scientific management of vegetation resources on Zhoushan Island and is of great significance to the sustainable development of the island region.