2001
DOI: 10.1093/emboj/20.13.3313
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Three-dimensional structure of the lithostathine protofibril, a protein involved in Alzheimer's disease

Abstract: Neurodegenerative diseases are characterized by the presence of filamentous aggregates of proteins. We previously established that lithostathine is a protein overexpressed in the pre‐clinical stages of Alzheimer's disease. Furthermore, it is present in the pathognomonic lesions associated with Alzheimer's disease. After self‐proteolysis, the N‐terminally truncated form of lithostathine leads to the formation of fibrillar aggregates. Here we observed using atomic force microscopy that these aggregates consisted… Show more

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Cited by 39 publications
(50 citation statements)
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“…Lithostathine-immunoreactive neurons were observed at the vicinity of diffuse plaques but never detected into amyloid plaques or neurofibrillary tangles as it has been shown earlier (de la Monte et al, 1990;Duplan et al, 2001;Ozturk et al, 1989).…”
Section: Discussionsupporting
confidence: 64%
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“…Lithostathine-immunoreactive neurons were observed at the vicinity of diffuse plaques but never detected into amyloid plaques or neurofibrillary tangles as it has been shown earlier (de la Monte et al, 1990;Duplan et al, 2001;Ozturk et al, 1989).…”
Section: Discussionsupporting
confidence: 64%
“…This function may be related to a putative involvement of lithostathine in plasticity mechanisms as suggested by De La Monte et al (de la Monte et al, 1990) or evidenced for an homologous regenerating protein Reg2 in central nervous system (Nishimune et al, 2000). In contrast, based on the pro-inflammatory property of lithostathine and its link to pro-inflammatory cytokines overexpression (Duplan et al, 2001), we propose that accumulation of lithostathine in the brain would also be an indirect consequence of peculiar chronic inflammatory status during aging (Franceschi and Bonafe, 2003;Giunta et al, 2008;Giunta, 2006). All in all, these findings indicate that lithostathine represents an interesting protein to be investigated for its role in aging.…”
Section: Discussionmentioning
confidence: 64%
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