2001
DOI: 10.1063/1.1423404
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Three-dimensional thermal noise imaging

Abstract: We present a scanning probe microscope based on optical tweezers for three-dimensional imaging of the topology of transparent material in the nanometer range. A spherical nanoparticle serves as a probe. An optical trap moves it through the sample ͑e.g., a polymer network͒, while the position of the particle center is recorded by three-dimensional interferometry. Accessible volumes are reconstructed from the histogram of thermal position fluctuations of the particle. The resolution in determining the position o… Show more

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Cited by 68 publications
(56 citation statements)
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“…The ability to measure the instantaneous velocity of a Brownian particle will be invaluable in studying nonequilibrium statistical mechanics [85,86]. The Brownian motion of a suspended particle can be used for microrheology to probe the properties of fluids, such as viscoelastic fluids [87][88][89], and surrounding environments [90][91][92]. He recently developed general methods to control the motion of atoms and molecules, and studied Brownian motion with unprecedented precision.…”
Section: Futurementioning
confidence: 99%
“…The ability to measure the instantaneous velocity of a Brownian particle will be invaluable in studying nonequilibrium statistical mechanics [85,86]. The Brownian motion of a suspended particle can be used for microrheology to probe the properties of fluids, such as viscoelastic fluids [87][88][89], and surrounding environments [90][91][92]. He recently developed general methods to control the motion of atoms and molecules, and studied Brownian motion with unprecedented precision.…”
Section: Futurementioning
confidence: 99%
“…It is also extensively used in multipixel measurements, either with split-detectors or quadrant detectors, to measure submicrometer displacements, for example of nanoscale fluorophores in biological samples [12] and in Atomic Force Microscopy [13], and ultra-small absorptions by the mirage effect [14].…”
Section: A Descriptionmentioning
confidence: 99%
“…Imaging metallic or plasmonic structures will be challenging in PBM because these samples can highly perturb TIR illumination as well as strongly interact with NPs. We believe that PBM's parallel scanning scheme much facilitates to visualize network nanostructures or biological objects compared with the demonstration of those by PFM with a single trapped particle [8,9].…”
Section: Resultsmentioning
confidence: 99%
“…Also, precise shaping of the tip geometry by etching [5,6] or functionalization with carbon nanotubes [7] enables SPM to image nanostructures with a higher aspect ratio, but the technique still cannot image 3D overhanging structures and cavities, as well as soft samples like biological materials. This limited imaging capability was well addressed by photonic force microscopy (PFM) [8,9] that replaces the conventional stiff probe with an optically trapped, sub-micron-sized particle as a soft probe. While PFM demonstrated truly 3D imaging of transparent (biological) objects, its imaging speed dependent on a single probe is still inherently slow.…”
Section: Introductionmentioning
confidence: 99%