Path tracking control is an important method for a Six-Degree-Of-Freedom Autonomous Underwater Vehicle to perform specific underwater tasks. Therefore, this paper investigates a dual-loop integral sliding mode control (DLISMC)-based tracking controller for an AUV with model uncertainties and external disturbances, and introduces a new reaction torque model for static compensation in order to improve the attitude control capability for AUVs when performing path tracking. In addition, the stability of tracking control law based on DLISMC is demonstrated using the Lyapunov function. Finally, numerical simulations are carried out on MATLAB 2016/Simulink and compared with the Proportion–Integral–Differential (PID) control commonly used in industry as well as the dual-loop Proportion–Integral–Differential (DLPID). Simulation results show that the DLISMC has a smaller tracking error, faster convergence speed, and more robustness against external disturbances and reaction torque.