Three-Dimensional Ultrasonography can Detect the Modulation of Kidney Volume in Two-Kidney, One-Clip Hypertensive Rats

Stormark, Tor André; Strømmen, Kenneth; Iversen, Bjarne M.; Matre, Knut

doi:10.1016/j.ultrasmedbio.2007.06.010

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…Our study is extending data from another study where it was shown that volume changes in the rat kidney can be measured in vivo with 3-D ultrasound using a position sensor [15,16]. Furthermore, ultrasonography examination was shown to be useful and reliable for diagnosing PKD in cats with polycystic kidney [17][18][19].…”

Section: Discussionsupporting

confidence: 68%

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

Kapoor¹,

Rodríguez²,

Mitchell

et al. 2016

Kidney Blood Press Res

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Background/Aims: The PCK rat model of polycystic kidney disease is characterized by the progressive development of renal medullary cysts. Here, we evaluated the suitability of high resolution ultrasonography (HRU) to assess the kidney and cyst volume in PCK rats, testing three different ultrasound image analysis methods, and correlating them with kidneys weights and histological examinations. Methods: After inducing anesthesia, PCK rats (n=18) were subjected to HRU to visualize the kidneys, to perform numeric and volumetric measurements of the kidney and any cysts observed, and to generate 3-dimensional images of the cysts within the kidney parenchyma. Results: HRU provided superior information in comparison to microscopic analysis of stained kidney sections. HRU-based kidney volumes correlated strongly with kidney weights (R²=0.809; P<0.0001). Conclusion: HRU represents a useful diagnostic tool for kidney and cyst volume measurements in PCK rats. Sequential HRU examinations may be useful to study the effect of drugs on cyst growth without the need to euthanize experimental animals.

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Section: Discussionsupporting

confidence: 68%

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

Kapoor¹,

Rodríguez²,

Mitchell

et al. 2016

Kidney Blood Press Res

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“…Yet others may be contributed by the physical and emotional stress caused by recurring biopsies [38]. Current development in dermatological ultrasound imaging positions it as a powerful non-invasive platform to quantitatively image blood flow, tissue kinetics, tissue stiffness, and its three-dimensional architecture [4,9,11,39,40]. The purpose of this study is to show that the ultrasonography is feasible in assessing the fetal wound healing…”

Section: Discussionmentioning

confidence: 99%

“…Waveforms were saved for later offline analysis. Heart rates of mother were measured from Doppler waveforms obtained from the heart and the uterine artery near the lateral-inferior margin of the uterocervical junction close to the iliac artery on each side [11,17]. The image resolution was maintained at 100 μm laterally and 50 μm axially.…”

Section: Plos Onementioning

confidence: 99%

“…Ultrasonography can assess anatomy, hemodynamics, and elastography which are the key factors to perform wound healing assessment non-invasively. In addition to these, ultrasound is a validated tool [9][10][11] to measure wound volume which is crucial to monitor the kinetics of wound healing over time. Identifying remodeling of the tissue and its scarring can be performed through the changes in tissue texture and granulation in ultrasound B-mode images and elastograms which proves this technique as powerful technique in wound healing assessments [12].…”

Section: Introductionmentioning

confidence: 99%

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High resolution ultrasound imaging for repeated measure of wound tissue morphometry, biomechanics and hemodynamics under fetal, adult and diabetic conditions

et al. 2020

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Non-invasive, repeated interrogation of the same wound is necessary to understand the tissue repair continuum. In this work, we sought to test the significance of non-invasive high-frequency high-resolution ultrasound technology for such interrogation. High-frequency high-resolution ultrasound imaging was employed to investigate wound healing under fetal and adult conditions. Quantitative tissue cellularity and elastic strain was obtained for visualization of unresolved inflammation using Vevo strain software. Hemodynamic properties of the blood flow in the artery supplying the wound-site were studied using color Doppler flow imaging. Non-invasive monitoring of fetal and adult wound healing provided unprecedented biomechanical and functional insight. Fetal wounds showed highly accelerated closure with transient perturbation of wound tissue cellularity. Fetal hemodynamics was unique in that sharp fall in arterial pulse pressure (APP) which was rapidly restored within 48h post-wounding. In adults, APP transiently increased post-wounding before returning to the pre-wounding levels by d10 post-wounding. The pattern of change in the elasticity of wound-edge tissue of diabetics was strikingly different. Severe strain acquired during the early inflammatory phase persisted with a slower recovery of elasticity compared to that of the non-diabetic group. Wound bed of adult diabetic mice (db/db) showed persistent hypercellularity compared to littermate controls (db/+) indicative of prolonged inflammation. Normal skin strain of db/+ and db/db were asynchronous. In db/db, severe strain acquired during the early inflammatory phase persisted with a slower recovery of elasticity compared to that of non-diabetics. This study showcases a versatile clinically relevant imaging platform suitable for real-time analyses of functional wound healing.

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“…The proximal renal tubules play a prominent role in urine filtration, being involved in the reabsorption of about two-thirds of the filtrate volume, and the recovery of many compounds from urine. 83 Proximal tubular cells, especially the activated proximal tubular epithelial cells, can contribute to tubulointerstitial lesions, reduction of renal function, interstitial inflammation, and the formation and development of fibrosis through chemotaxis, antigen presentation and cytokine autocrine and paracrine modes. 84,85 Drug targeting to the proximal tubular cells can significantly increase the concentration and efficacy of drugs used to treat renal tubular fibrosis.…”

Section: Renal Tubules As Targeting Sitementioning

confidence: 99%

Targeting strategies for drug delivery to the kidney: From renal glomeruli to tubules

Liu

Lin

et al. 2018

Medicinal Research Reviews

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Kidney diseases have become a global public health problem. The application of kidney-targeted drug-delivery systems in the management of kidney diseases has profound transformative potential. Kidney-targeted drug delivery can reduce the undesired side effects of often potent drugs and enhance drug efficacy in alleviating the kidney disease. Here, we review the literature on the potential strategies for targeting drugs to the kidneys. Specifically, we provide a broad overview of the targeting vectors and targeting pathways for renal tubules and glomeruli, as well as how the unique structural features of the glomerulus and the receptor-mediated internalization pathways of the tubules allows for drug targeting. Finally, we summarized the literature examples of drug delivery to the kidneys and elaborated strategies suitable for renal targeting to provide new therapeutic approaches for kidney diseases.

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Three-Dimensional Ultrasonography can Detect the Modulation of Kidney Volume in Two-Kidney, One-Clip Hypertensive Rats

Cited by 7 publications

References 22 publications

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

High Resolution Ultrasonography for Assessment of Renal Cysts in the PCK Rat Model of Autosomal Recessive Polycystic Kidney Disease

High resolution ultrasound imaging for repeated measure of wound tissue morphometry, biomechanics and hemodynamics under fetal, adult and diabetic conditions

Targeting strategies for drug delivery to the kidney: From renal glomeruli to tubules

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