Three-dimensional verification of 125I seed stability after permanent implantation in the parotid gland and periparotid region

Fan, Yi; Huang, Mianliang; Zheng, Lei; Zhao, Yijiao; Zhang, Jianguo

doi:10.1186/s13014-015-0552-z

Cited by 4 publications

(3 citation statements)

References 30 publications

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“…Although CT examination was advised for measurement on dimensional change according to the Desmoid Tumor Working Group 6 and NCCN guideline 5 , the 125 I seeds would affect the observation on the tumor outline on CT with radiological artifact. As an alternative, clinicians will measure the cluster volume of 125 I seeds and a general volumetric shrinkage tendency indirectly showed the shrinkage of tumor volume 35 . However, that was not a common parameter to use for comparison with other studies.…”

Section: Discussionmentioning

confidence: 99%

Long-term result of 125 I seed brachytherapy for pediatric desmoid tumor in the head and neck

Zhong

Lyu

Shi

et al. 2022

Preprint

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Background: Desmoid tumor (DT) is rare and challenging, often affects head neck (HN) region in children, and its appropriate treatments are under discussed. This study aimed to retrospectively evaluate long-term effectiveness and safety of I seed brachytherapy for pediatric DT in HN. Procedure: Seven pediatric patients with median age of 3 years old suffered from DT in HN treated with I brachytherapy from January 2008 to June 2018 were included. Among which, 5 underwent sole brachytherapy and the others combined with surgery under a prescription doses ranging from 10 000 cGy to 12 000 cGy. The rate of local control (LC), complete response (CR) and partial response (PR) were calculated after evaluation by radiological and pathological means. The radiation-associated toxicities were also evaluated Results: The LC rate was 7/7 during the follow-up time ranging from 43 to 135 months and with a mean of 57 months. No recurrent lesion was found in the patients receiving surgery combined with brachytherapy. In patients treated with sole brachytherapy, the radiological PR rate and CR rate were 4/5 and 1/5, respectively. In those reaching radiological PR, 3/4 were pathological CR. Slight acute radiation-associated toxicities were observed in all patients, and no late or severe acute toxicity was observed. Conclusion: I brachytherapy is effective and safe in the management of pediatric DT in HN as sole modality or combined with surgery in long term.

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Section: Discussionmentioning

confidence: 99%

Long-term result of 125 I seed brachytherapy for pediatric desmoid tumor in the head and neck

Zhong

Lyu

Shi

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Although CT examination was advised for the measurement of dimensional change according to the Desmoid Tumor Working Group 6 and NCCN guidelines, 5 the 125 I seeds would affect the observation of the tumor outline on CT with a radiological artifact. As an alternative, clinicians will measure the cluster volume of 125 I seeds, and a general volumetric shrinkage tendency indirectly showed the shrinkage of tumor volume 37 . However, that was not a common parameter to use for comparison with other studies.…”

Section: Discussionmentioning

confidence: 99%

Long‐term result of ¹²⁵I seed brachytherapy for pediatric desmoid tumor in the head and neck

Zhong

Lyu

Shi

et al. 2022

Pediatric Blood & Cancer

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Background Desmoid tumor (DT) is rare and challenging, often affects the head and neck (HN) region in children, and its appropriate treatments are under‐discussed. This study aimed to retrospectively evaluate the long‐term effectiveness and safety of 125I seed brachytherapy for pediatric DT in HN. Procedure Seven pediatric patients with a median age of three years who suffered from DT in HN treated with 125I brachytherapy from January 2008 to June 2018 were included. Among these, five underwent sole brachytherapy and the others combined with surgery under prescription doses ranging from 10,000 to 12,000 cGy. The rate of local control (LC), complete response (CR), and partial response (PR) was calculated after evaluation by radiological and pathological means. Radiation‐associated toxicities were also evaluated. Results The LC rate was 7/7 during the follow‐up time ranging from 43 to 135 months and with a mean of 57 months. No recurrent lesion was found in the patients receiving surgery combined with brachytherapy. In patients treated with sole brachytherapy, the radiological PR rate and CR rate were 4/5 and 1/5, respectively. In those reaching radiological PR, 3/4 were pathological CR. Slight acute radiation‐associated toxicities were observed in all patients, and no late or severe acute toxicity was observed. Conclusion 125I brachytherapy is effective and safe in the management of pediatric DT in HN as the sole modality or combined with surgery in the long term.

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“…The volume of the minimum bounding box, defined as the smallest-volume box including all of the points in a point cluster, was used for quantitative evaluation of the coverage of a seed point cluster. The volume was automatically calculated by the algorithm in Geomagic software for comparison [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Clinical application and accuracy assessment of imaging-based surgical navigation guided 125I interstitial brachytherapy in deep head and neck regions

Zhang

et al. 2022

Journal of Radiation Research

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Brachytherapy has the advantages of being minimally invasive and highly conformal, and it achieves good results in head and neck tumors. To precisely implant the radioactive seeds according to the preplan in deep head and neck regions, the surgical navigation is applied. This study aims to explore the clinical application and accuracy of imaging-based surgical navigation-guided 125I interstitial brachytherapy in terms of seed position. We included 41 patients with tumors in deep head and neck regions. The brachytherapy treatment plan was designed, and the preplanned data were transferred to the navigation system. Needle implantation and seed delivery were performed under surgical navigation system guidance with or without the combination of individual template. The treatment accuracy was evaluated by comparing seed cluster locations between the preoperative treatment plan and the postoperative treatment outcome. A total of 2879 seeds were delivered. The range, mean and median distances between the geometric centers of the preoperative seed point clusters and the postoperative seed point clusters were 0.8–10.5 mm, 4.5 ± 2.3 mm and 4.1 mm, respectively. The differences between preoperative and postoperative volumes of the minimum bounding box of seed point clusters were nonsignificant. In conclusion, the imaging-based surgical navigation system is a promising clinical tool to provide the preplanned data for interstitial brachytherapy intraoperatively, and it is feasible and accurate for the real-time guidance of needle implantation and seed delivery in deep head and neck regions.

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Three-dimensional verification of 125I seed stability after permanent implantation in the parotid gland and periparotid region

Cited by 4 publications

References 30 publications

Long-term result of 125 I seed brachytherapy for pediatric desmoid tumor in the head and neck

Long-term result of 125 I seed brachytherapy for pediatric desmoid tumor in the head and neck

Long‐term result of ¹²⁵I seed brachytherapy for pediatric desmoid tumor in the head and neck

Clinical application and accuracy assessment of imaging-based surgical navigation guided 125I interstitial brachytherapy in deep head and neck regions

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Three-dimensional verification of 125I seed stability after permanent implantation in the parotid gland and periparotid region

Cited by 4 publications

References 30 publications

Long-term result of 125 I seed brachytherapy for pediatric desmoid tumor in the head and neck

Long-term result of 125 I seed brachytherapy for pediatric desmoid tumor in the head and neck

Long‐term result of 125I seed brachytherapy for pediatric desmoid tumor in the head and neck

Clinical application and accuracy assessment of imaging-based surgical navigation guided 125I interstitial brachytherapy in deep head and neck regions

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Long‐term result of ¹²⁵I seed brachytherapy for pediatric desmoid tumor in the head and neck