1990
DOI: 10.1016/0006-8993(90)91240-h
|View full text |Cite
|
Sign up to set email alerts
|

Three histamine receptors (H1, H2 and H3) visualized in the brain of human and non-human primates

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

14
165
0

Year Published

1998
1998
2013
2013

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 248 publications
(179 citation statements)
references
References 25 publications
14
165
0
Order By: Relevance
“…For parts 1 and 2 of study 1, blood samples were collected within 10 min prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9,12, 16, 24, 36, 48, 60, 72, 96, 120 and 144 h after dosing in each study period. For part 3 of study 1, blood samples were collected (i) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after dosing on days 1 and 7; (ii) prior to dosing (0 h) on days 5, 6, 12 and 13; and (iii) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3,4,6,9,12,16,24,36,48,60,72,96,120,144,168,192,216 and 240 h after dosing on day 14. For study 2, blood samples were collected (i) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after dosing on day 1; (ii) prior to dosing (0 h) on days 4, 7, 10 and 11; and (iii) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16, 24, 36, 48, 96, 168 and 240 h after dosing on day 12.…”
Section: Blood and Urine Samplingmentioning
confidence: 99%
See 1 more Smart Citation
“…For parts 1 and 2 of study 1, blood samples were collected within 10 min prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9,12, 16, 24, 36, 48, 60, 72, 96, 120 and 144 h after dosing in each study period. For part 3 of study 1, blood samples were collected (i) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after dosing on days 1 and 7; (ii) prior to dosing (0 h) on days 5, 6, 12 and 13; and (iii) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3,4,6,9,12,16,24,36,48,60,72,96,120,144,168,192,216 and 240 h after dosing on day 14. For study 2, blood samples were collected (i) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after dosing on day 1; (ii) prior to dosing (0 h) on days 4, 7, 10 and 11; and (iii) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16, 24, 36, 48, 96, 168 and 240 h after dosing on day 12.…”
Section: Blood and Urine Samplingmentioning
confidence: 99%
“…Histamine H3 auto-and hetero-receptors are highly expressed in brain regions, such as the prefrontal cortex, hippocampus and hypothalamus, that play an important role in attention, learning and memory [9][10][11]. The presynaptic H3 receptor, when activated, decreases the release of histamine, acetylcholine and norepinephrine from cholinergic neurons.…”
Section: Introductionmentioning
confidence: 99%
“…The H3 receptor was discovered in 1983 and cloned at the end of the twentieth century (1) and is mainly expressed in the CNS. H3 receptors predominate in the basal ganglia, with the highest densities in the globus pallidus (2). The H3 receptor is a presynaptic inhibitory autoreceptor that regulates the synthesis and release of histamine and also modulates the release of several other neurotransmitters such as acetylcholine, norepinephrine, serotonin, dopamine, and g aminobutyric acid.…”
mentioning
confidence: 99%
“…H1 receptors also play a key role in antipsychotic-induced weight gain and food intake Kroeze et al 2003;Matsui-Sakata et al 2005). The H1 receptors are mainly located in postsynaptic areas and are found abundantly in the cerebral cortex and limbic areas including the hypothalamus, amygdala and hippocampal areas (Martinez-Mir et al 1990); while some of the brain regions exert food intake and dietary regulation. In the limbic system, the ventromedial hypothalamus plays an important role in the regulation of food intake, obesity or energy metabolism, and anorectic action.…”
Section: Discussionmentioning
confidence: 99%
“…As one of the main histamine receptors, H1 receptors are found in the thalamus, hypothalamus, brainstem nuclei, amygdala, hippocampus, and prefrontal cortex (Martinez-Mir et al 1990). H1 receptors are associated with an intracellular G-protein (G q ) that activates the phospholipase C, and diacylglycerol (DAG)-sensitive activation of protein kinase C (PKC), phosphatidylinositol (PIP2) signaling pathways.…”
Section: Introductionmentioning
confidence: 99%