“…For parts 1 and 2 of study 1, blood samples were collected within 10 min prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9,12, 16, 24, 36, 48, 60, 72, 96, 120 and 144 h after dosing in each study period. For part 3 of study 1, blood samples were collected (i) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after dosing on days 1 and 7; (ii) prior to dosing (0 h) on days 5, 6, 12 and 13; and (iii) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3,4,6,9,12,16,24,36,48,60,72,96,120,144,168,192,216 and 240 h after dosing on day 14. For study 2, blood samples were collected (i) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16 and 24 h after dosing on day 1; (ii) prior to dosing (0 h) on days 4, 7, 10 and 11; and (iii) prior to dosing (0 h) and at 0.5, 1, 1.5, 2, 3, 4, 6, 9, 12, 16, 24, 36, 48, 96, 168 and 240 h after dosing on day 12.…”