1989
DOI: 10.1002/1097-0142(19890915)64:6<1366::aid-cncr2820640632>3.0.co;2-a
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Three infants with acute megakaryoblastic leukemia simulating metastatic tumor

Abstract: The diagnosis of acute megakaryoblastic leukemia (AMKL) (M7, French-American-British [FAB] classification) has rarely been made in children due, in part, to its pleomorphic morphology and ability to mimic other malignancies common in the pediatric age group. Three infants are described who had thrombocytopenia and the classical criteria of metastatic solid tumor in the bone marrow: patchy infiltration by cohesive clusters of cells with high nuclear cytoplasmic ratio and myelofibrosis in the bone marrow biopsy … Show more

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Cited by 25 publications
(2 citation statements)
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“…The disappearance of BM fibrosis after successful chemotherapy or BM transplantation is additional evidence of the reactive nature of myelofibrosis [22,24,53,54]. Some rather unusual findings in this study were skeletal pains from multiple osteolytic lesions [22,33,55], the presence of soft-tissue tumor [56] as in other types of AML M2, M5 [57], and of cohesive scanty clusters of 7-10 primitive-looking blast cells in BM aspirates, that may mimic metastatic solid tumors in the BM [58,59]. The presence of PDGF, TGF ␤, and fibronectin in extramedullary tumors suggests that specific expression of growth factor proteins by the leukemic cells may also selectively regulate tumor formation [60,61].…”
Section: Discussionmentioning
confidence: 87%
“…The disappearance of BM fibrosis after successful chemotherapy or BM transplantation is additional evidence of the reactive nature of myelofibrosis [22,24,53,54]. Some rather unusual findings in this study were skeletal pains from multiple osteolytic lesions [22,33,55], the presence of soft-tissue tumor [56] as in other types of AML M2, M5 [57], and of cohesive scanty clusters of 7-10 primitive-looking blast cells in BM aspirates, that may mimic metastatic solid tumors in the BM [58,59]. The presence of PDGF, TGF ␤, and fibronectin in extramedullary tumors suggests that specific expression of growth factor proteins by the leukemic cells may also selectively regulate tumor formation [60,61].…”
Section: Discussionmentioning
confidence: 87%
“…The grouping of blast cells in AMKL--especially in the childhood period--shows similarities to metastatic tumors (4-7). Penchansky et al reported three cases of AMKL in children with cohesive clusters of blast cell infiltration in bone marrow biopsy simulating metastatic carcinoma (7). Ashfaq et al reported an additional case of AMKL in an infant with an abdominal mass resembling epithelial malignant neoplasm (5).…”
Section: Discussionmentioning
confidence: 99%