This paper discusses the essence and application specifics of the multimode rectifiers in high step-up DC-DC converters. It presents an overview of existing multimode rectifiers. Their use enables operation in the wide input voltage range needed in highly demanding applications. Owing to the rectifier mode changes, the converter duty cycle can be restricted to a range with a favorable efficiency. It is shown that the performance of such converters depends on the front-end inverter type. The study considers current- and impedance-source front-end topologies, as they are the most relevant in high step-up applications. It is explained why the full- and half-bridge implementations provide essentially different performances. Unlike the half-bridge, the full-bridge implementation shows step changes in efficiency during the rectifier mode changes, which could compromise the long-term reliability of the converter. The theoretical predictions are corroborated by experimental examples to compare performance with different boost front-end inverters.