IntroductionWe report the case of a patient with distal migration of a floating carotid thrombus caused by oral contraceptives.Case presentationA 48-year-old woman using oral contraceptives suffered from dysarthria and gait disturbance. Examinations, including ultrasound and cerebral arteriogram, revealed a floating thrombus at the left carotid bifurcation with no stenosis. Despite antithrombotic therapy, the floating carotid thrombus migrated to the ipsilateral middle cerebral artery, resulting in a severe stroke.ConclusionSome floating thrombi are resistant to conservative therapy and have a risk of distal migration, which may cause a major stroke in the acute stage.