2004
DOI: 10.1248/cpb.52.1029
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Three New Cytotoxic Cyclic Acylpeptides from Marine Bacillus sp.

Abstract: Three new cytotoxic cyclopeptides belonging to iturin class have been isolated from marine bacterium Bacillus sp. These three compounds have the cytotoxic activities. Their structures were determined based on chemical analysis and all kinds of spectroscopic techniques.

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Cited by 70 publications
(42 citation statements)
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“…Cytotoxic mixirins A, B and C were isolated from a marine Bacillus sp. 12 Tauramamide antagonistic to Enterococcus sp. was isolated from marine Brevibacillus laterosporus.…”
Section: Introductionmentioning
confidence: 99%
“…Cytotoxic mixirins A, B and C were isolated from a marine Bacillus sp. 12 Tauramamide antagonistic to Enterococcus sp. was isolated from marine Brevibacillus laterosporus.…”
Section: Introductionmentioning
confidence: 99%
“…The 1 H-and 13 C-NMR spectra of compound 1 showed close similarity to those of mixirin A, a cyclic peptide, which has been isolated from marine Bacillus sp. 7) The COSY data showed the presence of one Ser, one Pro, one Gln, one Tyr, three Asn residues and a residue having a long alkyl chain. Further analyses of COSY, HMQC and HMBC data revealed this residue to be 3-amino tetradecanoic acid (-amino acid).…”
Section: Resultsmentioning
confidence: 97%
“…The third family of fengycins includes fengycins A and B, which consists of a 10 amino acid peptide, in which residues 3-10 form a cyclic octapeptide, via a lactone bond for fengycins. 7) Several cyclo lipopeptides, cyclomarins A-C, 7) kurstakins, 8) mixirin A, B and C, 9) and scopularides A and B 10) have been discovered in recent years. These molecules exhibited biological activities such as antifungal, antitumor and antibacterial activity.…”
mentioning
confidence: 99%
“…Among them, mixirin A, B and C, members of the iturin class, exhibited antitumor activity in vitro. 9) This paper describes the isolation, structural elucidation and antifungal bioassay of the two new cyclic lipopeptides.…”
mentioning
confidence: 99%