Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of <i>Lycium barbarum</i> and Their Antioxidant Activities

Gao, Kai; Ma, Dongwei; Chen, Yan; Tian, Xiangrong; Lu, Yang; Du, Xiao-Ying; Tang, Haifeng; Chen, Jianzong

doi:10.1021/jf5049222

Cited by 76 publications

(65 citation statements)

References 32 publications

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“…trans ‐3‐ O ‐(6‐ O‐trans‐p ‐Coumaroyl‐ β ‐ d ‐glucopyranosyl)‐9‐ O‐β ‐ d ‐glucopyranosyl caffeic acid, a coumaroyl glycoside isolated from Clematis tashiroi , can scavenge 99.4% of added DPPH . Gao et al isolated a coumaroyl amide ( N ‐( E )‐coumaroyl tyramine) from Lycium barbarum and found that, at 0.1 mmol L −1 , it showed higher scavenging capacity for DPPH than BHA, and inhibited the production of thiobarbituric acid reactive substances by 92.6%, 85%, and 95.9% in the lipid peroxidation system of rat liver microsomes induced by ascorbate/Fe 2+ , cumine hydroperoxide, and CCl 4 /NADPH, respectively …”

Section: Biological Activitiesmentioning

confidence: 99%

p‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

et al. 2016

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p-Coumaric acid (4-hydroxycinnamic acid) is a phenolic acid that has low toxicity in mice (LD50 = 2850 mg kg(-1) body weight), serves as a precursor of other phenolic compounds, and exists either in free or conjugated form in plants. Conjugates of p-coumaric acid have been extensively studied in recent years due to their bioactivities. In this review, the occurrence, bioavailability and bioaccessibility of p-coumaric acid and its conjugates with mono-, oligo- and polysaccharides, alkyl alcohols, organic acids, amine and lignin are discussed. Their biological activities, including antioxidant, anti-cancer, antimicrobial, antivirus, anti-inflammatory, antiplatelet aggregation, anxiolytic, antipyretic, analgesic, and anti-arthritis activities, and their mitigatory effects against diabetes, obesity, hyperlipaemia and gout are compared. Cumulative evidence from multiple studies indicates that conjugation of p-coumaric acid greatly strengthens its biological activities; however, the high biological activity but low absorption of its conjugates remains a puzzle. © 2015 Society of Chemical Industry.

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Section: Biological Activitiesmentioning

confidence: 99%

p‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

et al. 2016

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“…Sixteen amides 107 – 122 have been isolated from the root bark of L. chinense [ 9 , 54 , 60 , 77 , 78 , 79 , 80 ], 19 amides ( 123 – 141 ) have been isolated from the fruits of L. barbarum [ 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ]. Meanwhile, two cerebrosides 142 and 143 have been obtained from fruits of L. chinense [ 89 ].…”

Section: Constituentsmentioning

confidence: 99%

Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae)

et al. 2017

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The Lycium genus is widely used as a traditional Chinese medicine and functional food. Many of the chemical constituents of the genus Lycium were reported previously. In this review, in addition to the polysaccharides, we have enumerated 355 chemical constituents and nutrients, including 22 glycerogalactolipids, 29 phenylpropanoids, 10 coumarins, 13 lignans, 32 flavonoids, 37 amides, 72 alkaloids, four anthraquinones, 32 organic acids, 39 terpenoids, 57 sterols, steroids, and their derivatives, five peptides and three other constituents. This comprehensive study could lay the foundation for further research on the Lycium genus.

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“…Moreover, monomers and dimers of phenolic amides containing N‐feruloyl tyramine units, called lyciumamides, were discovered and isolated confirming their structure by NMR analysis .…”

Section: Introductionmentioning

confidence: 86%

Optimization of pressurized liquid extraction by response surface methodology of Goji berry (Lycium barbarum L.) phenolic bioactive compounds

et al. 2018

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Pressurized liquid extraction (PLE) has been used for the first time in this work to extract phenolic compounds from Goji berries according to a multilevel factorial design using response surface methodology. The global yield (% w/dw, weight/dry‐weight), total phenolic content (TPC), total flavonoid (TF) and antioxidant activity (determined via ABTS assay, expressed as TEAC value) were used as response variables to study the effects of temperature (50–180°C) and green solvent composition (mixtures of ethanol/water). Phenolic compounds characterization was performed by high performance liquid chromatography–diode array detector–tandem mass spectrometry (HPLC‐DAD‐MS/MS). The optimum PLE conditions predicted by the model were as follows: 180°C and 86% ethanol in water with a good desirability value of 0.815. The predicted conditions were confirmed experimentally and once the experimental design was validated for commercial fruit samples, the PLE extraction of phenolic compounds from three different varieties of fruit samples (Selvatico mongolo, Bigol, and Polonia) was performed. Nine phenolic compounds were tentatively identified in these extracts, including phenolic acids and their derivatives, and flavonols. The optimized PLE conditions were compared to a conventional solid‐liquid extraction, demonstrating that PLE is a useful alternative to extract phenolic compounds from Goji berry.

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Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities

Cited by 76 publications

References 32 publications

p‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

p‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

Systematic Review of Chemical Constituents in the Genus Lycium (Solanaceae)

Optimization of pressurized liquid extraction by response surface methodology of Goji berry (Lycium barbarum L.) phenolic bioactive compounds

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