Three New Hydroxyphenylacetic Acid Derivatives and A New Alkaloid from Endophytic Fungus Mortierella sp. in Epimedium acuminatum Franch. and Their Antibacterial Activity

Abstract

Three new hydroxyphenylacetic acid derivatives, stachylines E-G (1 -3), and a new alkaloid, mortieridinone (4), along with six known compounds (5 -10), were isolated from endophytic fungus Mortierella sp. in Epimedium acuminatum Franch. Their structures were determined by their spectroscopic analyses and by comparison with the literature data. Compounds 7 and 10 showed selective antibacterial activity against tested multidrugresistant bacteria with minimum inhibitory concentration (MIC) values ranging from 25 to 3.13 μg/mL.

Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf

“…Comparison of its NMR data with those of stachyline G from Mortierella sp. revealed closed similarities except for the presence of an additional oxygenated methyl signal [ 15 ]. Extensive analysis of its HMBC spectrum revealed key signals from H 3 -9 to C-8, indicating that the methoxy was linked to C-8 and formed a methyl ester group.…”

“…The 1 H- 1 H COSY correlation of H 2 -10/H-11 and the HMBC correlations of H 2 -10 with C-4 and C-11, H-11 with C-12, and H 3 -13/H 3 -14 with C-11 and C-12 support the above deduction. In addition, the planar structure of 12 was similar to the known compound stachyline E except for the presence of an additional oxygenated methyl [ 15 ]. The recorded optical rotation for 12 was −4 ( c 0.1, CH 3 OH), which has the same angle as that of stachyline E, −6 ( c 0.1, CH 3 OH), suggesting that the configuration of C-11 in 12 is the same as that of stachyline E. Consequently, the structure of 12 was determined and assigned stachyline J ( 12 ).…”

Root-Layer Fungi Native to Four Volcanic Topographies on Conserved Ocean Islands: Another Clue to Facilitate Access to Newer Natural Microbial Resources in the Extreme Terrains

“…The most dominant fungal genera in all topographies was Mortierella (Dongdo: 27.65%, Seodo: 12.84%, Nari caldera: 11.54%, tuff layer: 8.4%) (Figure 3). Since this genera has consistently been reported as an endophytic or saprophytic plant symbiont [51][52][53][54][55][56] and marine terrains with tolerances [57,58], its emergence in all the volcanic topographies might indicate the existence of stable organic cycles [59] and their own ecology formation.…”

Azaphilones from the Fungus Penicillium multicolor LZUC‐S2 and Their Antibacterial Activity

“…[12 -14] Hence, fungi have gained an important role as a rich source for the discovery of novel antibacterial drugs to fight the crisis of antibiotic resistance. [15][16][17] With the purpose of searching for novel antibacterial secondary metabolites from fungi, a fungal strain Penicillium multicolor LZUC-S2 isolated from the soil which was collected near the fibrous roots of a healthy Euphorbia pekinensis Rupr. aroused our attention, because its ethyl acetate (AcOEt) extract displayed significant antibacterial activity against the human pathogenic bacteria Staphylococcus aureus and methicillin resistant Staphylococcus aureus (MRSA).…”

“…Particularly, many important clinical antibiotics were produced by fungi, such as penicillin, ampicillin, cephalosporins, fusidic acid and so on [12–14] . Hence, fungi have gained an important role as a rich source for the discovery of novel antibacterial drugs to fight the crisis of antibiotic resistance [15–17] …”