Three new naphthoquinones from the tubers of <i>Sinningia mauroana</i>

Winiewski, Vanessa; Mesquita, Mariana; Salvador, Marcos José; Sá, Eduardo L. de; Stefanello, Maria Élida Alves

doi:10.1080/14786419.2021.1969564

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…Ini adalah senyawa antaquinone yang telah terbukti tectoquinone adalah senyawa alami yang sedang diselidiki untuk potensi efek farmakologisnya (Wanschura, 2020). Ini telah menunjukkan potensi dalam beberapa area seperti antioksidan, antiinflamasi (Winiewski et al, 2023), antikanker (Ekiert and Szopa, 2020), antimikroba (Mansour et al, 2023), antidiabetes (Kouamé et al, 2019 dan neuroproteksi (Ekiert and Szopa, 2020). Oleh karena itu, upaya penelitian dilakukan, menggunakan metode in silico, untuk mengeksplorasi potensi tectoquinone sebagai penghambat α-glukosidase.…”

Section: Pendahuluanunclassified

Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase

Najib,

Razak,

Mujtahid

2023

IJPF

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The investigation focused on conducting an in silico screening of chemical compounds isolated from Syzygium oblanceolatum (C.B.Rob) to identify potential bioactive compounds that could act as inhibitors of α-Glucosidase. This screening involved tectoquinone as the potential inhibitor for α-Glucosidase and employed the Autodock Vina Docking process. The target enzyme, α-Glucosidase, was used as the receptor with 20 binding sites on the enzyme receptor 1LWJ and the Autodock Vina program was utilized for this purpose. The values of ∆Gbind and the lowest RMSD were determined for each of the 20 targeted binding sites on 1LWJ, representing the free energy change (∆G) resulting from the docking. The docking results demonstrated that the free energy change (∆G) for the 20 targeted binding sites ranged from -6.346 kcal/mol to -9.720 kcal/mol. The most favorable free energy change (∆G) was observed at the 16th binding site with a value of -9.720 kcal/mol, while the highest was recorded at the 18th binding site with a value of -6.346 kcal/mol.

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Section: Pendahuluanunclassified

Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase

Najib,

Razak,

Mujtahid

2023

IJPF

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“…[8][9][10][11][12] The species of Gesneriaceae are traditionally used for respiratory problems, wounds, fever, inflammation, pain, snake bites, and infectious diseases. 10,12,13,14,15,16 Phytochemical research on Sinninigia species has mainly reported the identification of terpenes, phenolic glycosides, and compounds from the quinone class, some with documented biological activities such as antioxidant, anti-inflammatory properties, and cytotoxic activity for cancer cell lines. 10,12,14,15,16,17,18,19,20,21,22 Sinningia magnifica (Otto & A.…”

Section: Introductionmentioning

confidence: 99%

“…10,12,13,14,15,16 Phytochemical research on Sinninigia species has mainly reported the identification of terpenes, phenolic glycosides, and compounds from the quinone class, some with documented biological activities such as antioxidant, anti-inflammatory properties, and cytotoxic activity for cancer cell lines. 10,12,14,15,16,17,18,19,20,21,22 Sinningia magnifica (Otto & A. Dietr.)…”

Section: Introductionmentioning

confidence: 99%

“…In Brazil, the south and southeast regions are places where Sinningia species are most frequently found 5‐9 . At least 75 species of herbs comprise the Sinningia genus, most of them native to Brazil 8‐12 . The species of Gesneriaceae are traditionally used for respiratory problems, wounds, fever, inflammation, pain, snake bites, and infectious diseases 10,12,13,14,15,16 …”

Section: Introductionmentioning

confidence: 99%

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Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

Serain,

Buitrago‐Mejia,

de Souza

et al. 2023

Photochem & Photobiology

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Photodynamic therapy (PDT) has been used for various purposes, including as an antitumor resource in a noninvasive therapy with minimal side effects. Sinningia magnifica (Otto & A. Dietr.) Wiehler is a rupicolous plant found in rock crevices in Brazilian tropical forests. Initial studies indicate the presence of phenolic glycosides and anthraquinones in species of the genus Sinningia (Generiaceae family). It is known that anthraquinones are natural photosensitizers with potential PDT applications. This led us to investigate the potential compounds of S. magnifica for use as a natural photosensitizer against the melanoma (SK‐MEL‐103) and the prostate cancer (PC‐3) cell lines in a bioguided study. Our results showed that singlet oxygen production by the 1,3‐DPBF photodegradation assay greatly increased in the presence of crude extract and fractions. The biological activity evaluation showed photodynamic action against melanoma cell line SK‐MEL‐103 and prostate cell line PC‐3. These results suggest the presence of potential photosensitizing substances, as demonstrated in this in vitro antitumor PDT study by the naphthoquinones Dunniol and 7‐hydroxy‐6‐methoxy‐α‐dunnione for the first time. Naphthoquinones, anthraquinones and phenolic compounds were identified in the crude extract by UHPLC–MS/MS analysis, motivating us to continue with the bioguided phytochemical study aiming to discover more photochemically bioactive substances in Gesneriaceae plants.

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One new phenylpropanoid glycoside from Paraboea rufescens and their chemotaxonomic significance

Li,

Chen,

et al. 2024

Biochemical Systematics and Ecology

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Three new naphthoquinones from the tubers of Sinningia mauroana

Cited by 6 publications

References 9 publications

Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase

Studi Penambatan Molekuler Senyawa Tectoquinone Terhadap Enzim α-Glukosidase

Antitumoral photoinduced effects of crude extract, fractions, and naphthoquinones from Sinningia magnifica (Otto & A. Dietr.) Wiehler (Gesneriaceae) in a bioguided study

One new phenylpropanoid glycoside from Paraboea rufescens and their chemotaxonomic significance

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