Three new sesquiterpenoids from cultures of the basidiomycete<i>Conocybe siliginea</i>

Yang, Xiaoyan; Li, Zhenghui; Dong, Zhibao; Feng, Tao; Liu, Ji‐Kai

doi:10.1080/10286020.2014.939072

Cited by 20 publications

(7 citation statements)

References 8 publications

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“…Two new fungal hybrid polyketides, cladosin F ( 39 ) and G ( 40 ) ( Figure 4 ), with a rare 6(3)-enamino-8,10-dihydroxy-tetraketide system have been discovered from the deep-sea-derived fungus Cladosporium sphaerospermum 2005-01-E3, guided by the OSMAC approach. Both exhibit weak in vitro antitumor activity [ 44 ].…”

Section: Bioactive Metabolites Of Deep-sea Fungimentioning

confidence: 99%

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

2015

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Deep-sea fungi, the fungi that inhabit the sea and the sediment at depths of over 1000 m below the surface, have become an important source of industrial, agricultural, and nutraceutical compounds based on their diversities in both structure and function. Since the first study of deep-sea fungi in the Atlantic Ocean at a depth of 4450 m was conducted approximately 50 years ago, hundreds of isolates of deep-sea fungi have been reported based on culture-dependent methods. To date more than 180 bioactive secondary metabolites derived from deep-sea fungi have been documented in the literature. These include compounds with anticancer, antimicrobial, antifungal, antiprotozoal, and antiviral activities. In this review, we summarize the structures and bioactivities of these metabolites to provide help for novel drug development.

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Section: Bioactive Metabolites Of Deep-sea Fungimentioning

confidence: 99%

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

2015

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“…Sesquiterpenes, as major constituents isolated from the Vladimiria species, possess various types of structures including guaianolide, carabrane, eudesmane and germacrane sesquiterpenes89101112. The plant of Vladimiria souliei , as a traditional Chinese medicine, has been used for relieving pain and stomach diseases since ancient times713.…”

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confidence: 99%

Vlasouliolides A-D, four rare C17/C15 sesquiterpene lactone dimers with potential anti-inflammatory activity from Vladimiria souliei

Chen

Zhang

et al. 2017

Sci Rep

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Vlasouliolides A-D (1–4), four rare sesquiterpene lactone dimers, were isolated from Vladimiria souliei. The common structural characteristic of 1–4 is the C32 skeleton comprising two sesquiterpene lactone units linked by a C11-C13′ single bond with one acetyl connected to the C-13 position of one of the two sesquiterpene lactone units. The stereochemistries of 1–4 were assigned by a combination of NOESY correlations and Cu-Κα X-ray crystallographic analyses. Compounds 1–4 strongly inhibited the production of NO in LPS-stimulated RAW 264.7 cells. Furthermore, 1 and 2 inhibited the activation of NF-κB in LPS-induced 293T cells.

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“…X-ray crystallographic analysis of 5 allowed assignment of the structure and absolute configuration [25]. A related protoilludane, 5-O-acetyl-7,14-dihydroxy-protoilludanol (6), was isolated from Conocybe siliginea, the structure and relative configuration of which were assigned using rotatingframe nuclear Overhauser effect spectroscopy (ROESY) spectroscopic data [26]. The cytotoxicity of 6 was investigated against several human cancer cell lines including SK-BR-3, SMMC-7721, HL-60, PANC-1 and A-549 and was found to be non-cytotoxic [26].…”

Section: Protoilludane Sesquiterpenesmentioning

confidence: 99%

A Review of Fungal Protoilludane Sesquiterpenoid Natural Products

2020

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Natural products have been a great source for drug leads, due to a vast majority possessing unique chemical structures. Such an example is the protoilludane class of natural products which contain an annulated 5/6/4-ring system and are almost exclusively produced by fungi. They have been reported to possess a diverse range of bioactivities, including antimicrobial, antifungal and cytotoxic properties. In this review, we discuss the isolation, structure elucidation and any reported bioactivities of this compound class, including establishment of stereochemistry and any total syntheses of these natural products. A total of 180 protoilludane natural products, isolated in the last 70 years, from fungi, plant and marine sources are covered, highlighting their structural diversity and potential in drug discovery.

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Three new sesquiterpenoids from cultures of the basidiomyceteConocybe siliginea

Cited by 20 publications

References 8 publications

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

A Brief Review of Bioactive Metabolites Derived from Deep-Sea Fungi

Vlasouliolides A-D, four rare C17/C15 sesquiterpene lactone dimers with potential anti-inflammatory activity from Vladimiria souliei

A Review of Fungal Protoilludane Sesquiterpenoid Natural Products

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