Three New Spiny Euphorbia (Euphorbiaceae) Species From Western Saudi Arabia

Fayed, A. A.; Alzahrani, Dhafer A.

doi:10.1017/s0960428607000844

Cited by 18 publications

(19 citation statements)

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“…It is widely distributed in central Africa and the southern Arabian Peninsula and reaches up to 3 m high. Fruit capsules are dull red 3-angular with 8–9 × 15–16 mm in size [ 13 ]. The extract of E. cactus latex showed antileishmanial activity [ 14 ], whereas the crude methanolic extract of the whole plant has been reported to exhibit antioxidant, antimicrobial, and anticancer activities [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Unprecedented Insights on Chemical and Biological Significance of Euphorbia cactus Growing in Saudi Arabia

Al-Hamoud

Khan

Amina

et al. 2022

Plants

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Euphorbia cactus Ehrenb ex Boiss. is a plant species reported from central Africa and the southern Arabian Peninsula, belonging to the family of Euphorbiaceae. The plant has ethnobotanical values and is well-known for its milky latex, which has been turned into medicine to treat various ailments. To the best of our knowledge, there have been no literature reports available on phytochemical constituents and antiproliferative mechanism of E. cactus. In the current study, the phytochemical investigation of E. cactus methanolic extract (ECME) resulted in the isolation and characterization of four secondary metabolites, which are reported for the first time from this plant species. In addition, the results of 1,1-diphenyl-2-picrylhydrazyl (DPPH•) and ferrous ion chelating (FIC) assays expressed maximum antioxidant activity by ECME and the isolated phytochemicals. Furthermore, ECME exerted a promising antiproliferative effect against different cancer cell lines, and the A549 lung cancer cells were the most sensitive with an IC50 value of 20 µg/mL. The antiproliferative action of ECME in A549 cells was associated with cell accumulation in the G2/M phase and an increase in early and late apoptosis. In addition, RT-PCR and western blot analysis revealed that ECME decreased the anti-apoptotic (Bcl-2) expression, while the expression of pro-apoptotic (Bax) and caspase-3 were increased. This study provides the first insight into the phytochemical constituents and the antiproliferative mechanism of ECME, implying that it could be exploited as a promising natural source for developing new cancer therapies. Further preclinical research is warranted to support the current results.

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Section: Introductionmentioning

confidence: 99%

Unprecedented Insights on Chemical and Biological Significance of Euphorbia cactus Growing in Saudi Arabia

Al-Hamoud

Khan

Amina

et al. 2022

Plants

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“…It includes about 2282 species (Thomas, 2011) and has early been studied by several workers (Migahid, 1989, Migahid, 1990, Mandaville, 1990, Collenette, 1999, Chaudhary, 1999, Chaudhary, 2000, Chaudhary, 2001). Recent explorations by subsequent workers brought several additions to the flora of Saudi Arabia (Alfarhan et al, 1997, Al-Turki, 2003, Fayed and Al-Zahrani, 2007, Masrahi et al, 2010, Masrahi et al, 2012a, Masrahi et al, 2012b, Thomas et al, 2014, Masrahi, 2015). These recent explorations have repeatedly indicated that the flora of most of the regions in Saudi Arabia is still under explored.…”

Section: Introductionmentioning

confidence: 99%

Phragmites australis (Poaceae): New addition to flora of southwestern Saudi Arabia

Remesh

Masrahi

Sayed

2019

Saudi Journal of Biological Sciences

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Phragmites australis (Poaceae) is a cosmopolitan reed grass, so far reported only in Eastern Region of Saudi Arabia. Our recent field exploration in the South West Region of Saudi Arabia resulted in documentation of this species in Gizan City (Jazan Region). The species is reported here as a first record in Jazan Region and an addition to Jazan flora. A note on distribution, ecology, and brief description of the plant is also provided.

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“…This diversity is caused by variation in geomorphological characteristics, which includes islands, sand dunes, sandy plains, low rocky hills and high mountains, generating a varied climate ranging from hot-extra arid to hot-arid to relatively low temperature-humid (Masrahi, 2012). In the recent years, floristic explorations have resulted in the discovery of many new taxa and records in this part of Saudi Arabia (Al Farhan, 2000, Al-Turki et al, 2001, Al-Turki et al, 2002, Al-Turki, 2003, Fayed and Al-Zahrani, 2007, Al-Zahrani and El-Karemy, 2007, Masrahi et al, 2010, Masrahi et al, 2012a, Thomas et al, 2014, Masrahi, 2015). Blepahris A. l. Juss.…”

Section: Introductionmentioning

confidence: 99%