Three Novel Immunosuppressive Steroidal Glycosides from the Stems of <b><i>Stephanotis Mucronata</i></b>

Li, Xiaoyu; Zong, Shu-Ling; Chen, Fengyang; Xu, Shijun; Ye, Yiping

doi:10.1177/1934578x1200701004

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Four known compounds were also isolated and identified as gymnepregoside H (5), [23] deacetylkidjoladinin (6), [34] gymnepregoside G (7) [23] and gymnepregoside I (8) [35], by comparison of spectroscopic data and physicochemical properties with those reported values in the literatures.…”

Section: Resultsmentioning

confidence: 84%

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Liu

Zhou²,

Zhang³

et al. 2021

Molecules

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Gymnema sylvestre (Retz.) Schult is a multi-purpose traditional medicine that has long been used for the treatment of various diseases. To discover the potential bioactive composition of G. sylvestre, a chemical investigation was thus performed. In this research, four new C21 steroidal glycosides sylvepregosides A-D (1–4) were isolated along with four known compounds, gymnepregoside H (5), deacetylkidjoladinin (6), gymnepregoside G (7) and gymnepregoside I (8), from the ethyl acetate fraction of G. sylvestre. The structures of the new compounds were established by extensive 1D and 2D nuclear magnetic resonance (NMR) spectra with mass spectroscopy data. Compounds 1–6 promoted glucose uptake by the range of 1.10- to 2.37-fold, respectively. Compound 1 showed the most potent glucose uptake, with 1.37-fold enhancement. Further study showed that compounds 1 and 5 could promote GLUT-4 fusion with the plasma membrane in L6 cells. The result attained in this study indicated that the separation and characterization of these compounds play an important role in the research and development of new anti-diabetic drugs and pharmaceutical industry.

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Section: Resultsmentioning

confidence: 84%

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Liu

Zhou²,

Zhang³

et al. 2021

Molecules

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Is the pharmaceutical industry’s preoccupation with the monotherapy drug model stifling the development of effective new drug therapies?

Cock

2018

Inflammopharmacol

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Drug discovery and development is heavily biased towards the development of monotherapies. Screening, testing, and evaluation of mono-entity drugs are generally much simpler than drug combinations, and are generally easier to get approval from the regulatory authorities for their clinical use. However, monotherapy drugs may not have optimal activity, may have associated toxicities, or may lose activity over time as their target develops resistance. Drug combinations, often developed from existing monotherapies, may have improved efficacy and/or be less toxic. Furthermore, the existing drugs which have lost efficacy due to the development of resistance can often be re-activated by combining them with other chemical entities. Thus, whilst the current climate for drug approval, registration, and clinical use drives the majority of drug development research towards the development of monotherapies, combinations are often a substantial improvement on the original drug. This commentary examines monotherapy and combinational therapy models and discusses the benefits and limitations of each model.

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Cytotoxic polyhydroxylated pregnane glycosides from Cissampelos pareira var. hirsuta

et al. 2022

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Three Novel Immunosuppressive Steroidal Glycosides from the Stems of Stephanotis Mucronata

Cited by 3 publications

References 5 publications

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Identification of C21 Steroidal Glycosides from Gymnema sylvestre (Retz.) and Evaluation of Their Glucose Uptake Activities

Is the pharmaceutical industry’s preoccupation with the monotherapy drug model stifling the development of effective new drug therapies?

Cytotoxic polyhydroxylated pregnane glycosides from Cissampelos pareira var. hirsuta

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