Three novel HLA‐C alleles identified in Russian individuals: C*04:01:124, C*12:02:38, and C*12:03:64

Abstract

Three new human leukocyte antigen (HLA)‐C alleles, C*04:01:124, C*12:02:38, and C*12:03:64, alleles detected in Russian individuals.

Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research

“…Moreover, NGS is ideal to detect new HLA variants. Researchers now routinely identify novel HLA alleles ( Nilsson et al, 2018 ; Ralazamahaleo et al, 2019 ; Loginova et al, 2020 ; Ananeva et al, 2021a ; Ananeva et al, 2021b ; Cheranev et al, 2021 ; Loginova et al, 2021 ) using NGS and confirm them using SBT with PCR-SBT error often responsible for non-concordance between the two. NGS-based sequencing of multiple exons and introns has led to increases in the growth of the IPD-IMGT-HLA Database collection ( Robinson et al, 2015 ; Robinson et al, 2019 ).…”