Three patients with systemic sclerosis complicated by microangiopathic hemolytic anemia and thrombocytopenia.

Matsubara, Akio; Nara, Hiroyuki; Kaneko, Naoko; Shirota, Yuko; Takeda, Atsushi; Masuyama, Jun-Ichi; Yoshio, Taku; Kano, Shogo; Minota, Seiji

doi:10.2177/jsci.23.57

Cited by 6 publications

(1 citation statement)

References 6 publications

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“…We reviewed the reported cases of normotensive SRC or SSc complicated by TMA in Japan, including those from Japanese language journals (13)(14)(15)(16)(17) (Table). Hypertensive SRC, ANCA-positive SRC and SSc complicated by TTP were excluded from our review.…”

Section: Discussionmentioning

confidence: 99%

Glucocorticoid-induced Normotensive Scleroderma Renal Crisis: A Report on Two Cases and a Review of the Literature in Japan

et al. 2013

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We herein report the findings of 2 cases of normotensive scleroderma renal crisis (SRC) that developed soon after the commencement of a glucocorticoid therapy. We also review 8 cases of normotensive SRC reported in Japan, including our cases. The common characteristics of these 8 cases are as follows: the recent onset of systemic sclerosis, the presence of diffuse skin sclerosis, the presence of myositis and/or serositis, a high titer of antinuclear antibody and positivity for anti-Scl-70 antibody. In 7 of the 8 patients, thrombotic microangiopathy developed within one month of starting the glucocorticoid treatment. We should be careful with the use of glucocorticoids in systemic sclerosis patients exhibiting these features in order to avoid cases of normotensive SRC.

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Section: Discussionmentioning

confidence: 99%

Glucocorticoid-induced Normotensive Scleroderma Renal Crisis: A Report on Two Cases and a Review of the Literature in Japan

et al. 2013

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Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: follow-up of immunopathological and clinical effects

et al. 2008

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Systemic sclerosis (SSc) is an autoimmune disease which involves the skin, as well as several internal organs. Most therapies available in this disease are symptomatic. Authors present a case of diffuse SSc with progressive disease not responding to currently available treatments. Therefore a 12-month protocol of repeated plasmapheresis and high-dose intravenous immunoglobulin treatment was administered with good clinical efficacy. Apart from monitoring the clinical symptoms throughout the treatment, authors also assessed a number of humoral and cellular immunolaboratory markers in order to obtain information on the immunomodulatory effects of this combined treatment in SSc.

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Thrombotic thrombocytopenic purpura presenting as bilateral flank pain and hematuria: a case report

Qasim

Partridge

2001

The Journal of Emergency Medicine

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Three patients with systemic sclerosis complicated by microangiopathic hemolytic anemia and thrombocytopenia.

Cited by 6 publications

References 6 publications

Glucocorticoid-induced Normotensive Scleroderma Renal Crisis: A Report on Two Cases and a Review of the Literature in Japan

Glucocorticoid-induced Normotensive Scleroderma Renal Crisis: A Report on Two Cases and a Review of the Literature in Japan

Combined plasmapheresis and high-dose intravenous immunoglobulin treatment in systemic sclerosis for 12 months: follow-up of immunopathological and clinical effects

Thrombotic thrombocytopenic purpura presenting as bilateral flank pain and hematuria: a case report

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