Three-phase bone quantitative-SPECT of navicular bones with a high-sensitivity whole-body CZT-camera in a Müeller-Weiss syndrome

Mairal, Elise; Imbert, Laëtitia; Marie, Pierre-Yves; Bahloul, Achraf

doi:10.1007/s00259-022-05733-9

Cited by 6 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of dynamic SPECT performed with CZT swivelling-detector ring cameras have already been reported for bone [ 12 ] and cardiac studies [ 13 ]. As far as we know, the present study is the first to evaluate in vivo the kidney function with such a camera and to compare it to standard dynamic planar imaging of the same subject.…”

Section: Discussionmentioning

confidence: 99%

Kidney dynamic SPECT acquisition on a CZT swiveling-detector ring camera: an in vivo pilot study

Hesse,

Dupont,

Mourad

et al. 2024

BMC Med Imaging

View full text Add to dashboard Cite

Background Large field of view CZT SPECT cameras with a ring geometry are available for some years now. Thanks to their good sensitivity and high temporal resolution, general dynamic SPECT imaging may be performed more easily, without resorting to dedicated systems. To evaluate the dynamic SPECT imaging by such cameras, we have performed an in vivo pilot study to analyze the kidney function of a pig and compare the results to standard dynamic planar imaging by a conventional gamma camera. Methods A 7-week-old (12 kg) female Landrace pig was injected with [99mTc]Tc-MAG3 and a 30 min dynamic SPECT acquisition of the kidneys was performed on a CZT ring camera. A fast SPECT/CT was acquired with the same camera immediately after the dynamic SPECT, without moving the pig, and used for attenuation correction and drawing regions of interest. The next day the same pig underwent a dynamic planar imaging of the kidneys by a conventional 2-head gamma camera. The dynamic SPECT acquisition was reconstructed using a MLEM algorithm with up to 20 iterations, with and without attenuation correction. Time-activity curves of the total counts of each kidney were extracted from 2D and 3D dynamic images. An adapted 2-compartment model was derived to fit the data points and extract physiological parameters. Comparison of these parameters was performed between the different reconstructions and acquisitions. Results Time-activity curves were nicely fitted with the 2-compartment model taking into account the anesthesia and bladder filling. Kidney physiological parameters were found in agreement with literature values. Good agreement of these parameters was obtained for the right kidney between dynamic SPECT and planar imaging. Regional analysis of the kidneys can be performed in the case of the dynamic SPECT imaging and provided good agreement with the whole kidney results. Conclusions Dynamic SPECT imaging is feasible with CZT swiveling-detector ring cameras and provides results in agreement with dynamic planar imaging by conventional gamma cameras. Regional analysis of organs uptake and clearance becomes possible. Further studies are required regarding the optimization of acquisition and reconstruction parameters to improve image quality and enable absolute quantification.

show abstract

Section: Discussionmentioning

confidence: 99%

Kidney dynamic SPECT acquisition on a CZT swiveling-detector ring camera: an in vivo pilot study

Hesse,

Dupont,

Mourad

et al. 2024

BMC Med Imaging

View full text Add to dashboard Cite

show abstract

“…At the present time, however, fast whole-body recordings and reliable standardized uptake values (SUV) measurements may be obtained not only with PET cameras but also with novel hybrid systems combining: (i) single-photon emission tomography (SPECT) recording through cadmium-zinc-telluride (CZT) detectors with an original 360° ring configuration geometry that is likely to maximize both count sensitivity and image quality and (ii) multi-detector computed tomography (CT) scanners providing the attenuation maps required for SUV quantification (Melki et al 2020;Bahloul et al 2021;Mairal et al 2022;Chevalier et al 2020). One such system, the high-speed VERITON CZT-SPECT/CT system (Spectrum Dynamics Medical, Caesarea, Israel) was previously shown to provide Melki et al European Journal of Hybrid Imaging (2023) 7:1 both reliable SUV measurements and high-quality bone scintigraphy images (Melki et al 2020;Bahloul et al 2021;Mairal et al 2022). A threshold of 7.5 SUV was additionally shown to grossly separate abnormal from normal bone metabolism areas (Bahloul et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies

Melki

Moulinet

Verger

et al. 2023

European J Hybrid Imaging

Self Cite

View full text Add to dashboard Cite

Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. 18F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized uptake value-based information provided by fast whole-body [Tc-99 m]-HDP bone tomoscintigraphies (QWBT) recorded with a high-sensitivity CZT-camera/computed tomography (CT) hybrid system.

show abstract

“…In parallel, SPECT imaging performances have improved considerably, owing to CZT technology, with the possibility of high contrast brain perfusion SPECT imaging ( Bordonne et al, 2020a , b ). CZT SPECT imaging is also associated with better spatial and temporal resolution in comparison to conventional systems, thus allowing dynamic 3D SPECT imaging ( Mairal et al, 2022 ). The objective of this case report was to evaluate the feasibility of functional SPECT (fSPECT) imaging for brain perfusion using a 360°CZT camera for identification of well-known resting-state networks.…”

Section: Introductionmentioning

confidence: 99%

Identification of resting-state networks using dynamic brain perfusion SPECT imaging: A fSPECT case report

Doyen

Hossu

Heyer

et al. 2023

Front. Hum. Neurosci.

Self Cite

View full text Add to dashboard Cite

Connectivity studies with nuclear medicine systems are scarce in literature. They mainly employ PET imaging and group level analyses due to the low temporal resolution of PET and especially SPECT imaging. Our current study analyses connectivity at an individual level using dynamic SPECT imaging, which has been enabled by the improved temporal resolution performances provided by the 360°CZT cameras. We present the case of an 80-year-old man referred for brain perfusion SPECT imaging for cognitive disorders for whom a dynamic SPECT acquisition was performed utilizing a 360°CZT camera (temporal sampling of 15 frames × 3 s, 10 frames × 15 s, 14 frames × 30 s), followed by a conventional static acquisition of 15 m. Functional SPECT connectivity (fSPECT) was assessed through a seed correlation analysis and 5 well-known resting-state networks were identified: the executive, the default mode, the sensory motor, the salience, and the visual networks. This case report supports the feasibility of fSPECT imaging to identify well known resting-state networks, thanks to the novel properties of a 360°CZT camera, and opens the way to the development of more dedicated functional connectivity studies using brain perfusion SPECT imaging.

show abstract

Three-phase bone quantitative-SPECT of navicular bones with a high-sensitivity whole-body CZT-camera in a Müeller-Weiss syndrome

Cited by 6 publications

References 5 publications

Kidney dynamic SPECT acquisition on a CZT swiveling-detector ring camera: an in vivo pilot study

Kidney dynamic SPECT acquisition on a CZT swiveling-detector ring camera: an in vivo pilot study

Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies

Identification of resting-state networks using dynamic brain perfusion SPECT imaging: A fSPECT case report

Contact Info

Product

Resources

About