“…From these, threshold-based algorithms have been widely used, mainly because of their simplicity. Thus, thresholding algorithms, such as the Otsu ( Celebi et al, 2007b;Celebi, Wen, Hwang, Iyatomi, & Schaefer, 2013;Norton et al, 2010Norton et al, , 2012, type-2 fuzzy logic ( Yuksel & Borlu, 2009 ) and the Renyi entropy method ( Beuren et al, 2012 ), aim to establish the threshold values in order to separate the regions of interest (ROIs) in the input images. However, these techniques may reveal some problems; for example the segmented lesions tend to be smaller than their real size, and the segmentation process may lead to highly irregular lesion borders ( Yuksel & Borlu, 2009 ).…”