Three-Phase-Lag Bio-Heat Transfer Model of Cardiac Ablation

Abstract

Significant research efforts have been devoted in the past decades to accurately modelling the complex heat transfer phenomena within biological tissues. These modeling efforts and analysis have assisted in a better understanding of the intricacies of associated biological phenomena and factors that affect the treatment outcomes of hyperthermic therapeutic procedures. In this contribution, we report a three-dimensional non-Fourier bio-heat transfer model of cardiac ablation that accounts for the three-phase-lags (TPL) in the heat propagation, viz., lags due to heat flux, temperature gradient, and thermal displacement gradient. Finite element-based COMSOL Multiphysics software has been utilized to predict the temperature distributions and ablation volumes. A comparative analysis has been conducted to report the variation in the treatment outcomes of cardiac ablation considering different bio-heat transfer models. The effect of variations in the magnitude of different phase lags has been systematically investigated. The fidelity and integrity of the developed model have been evaluated by comparing the results of the developed model with the analytical results of the recent studies available in the literature. This study demonstrates the importance of considering non-Fourier lags within biological tissue for predicting more accurately the characteristics important for the efficient application of thermal therapies.

Temperature Dependence of Thermal Properties of Ex Vivo Porcine Heart and Lung in Hyperthermia and Ablative Temperature Ranges

“…, beyond 76 °C) 10 , 48 which are reached during localized thermal therapies on these organs. 8 , 29 , 51 Hence, motivated by the limited data on heart and lung, and by the huge demand for accurate models for describing the heat transfer in these organs, this paper focuses on the measurement of the thermal properties of these tissues, from room temperature up to 94 °C. The thermal conductivity, thermal diffusivity, and volumetric heat capacity of ex vivo porcine heart and lung were measured with a dual-needle sensor technique, which has been previously validated by our group on other organs.…”

Non-Fourier Bioheat Transfer Analysis in Brain Tissue During Interstitial Laser Ablation: Analysis of Multiple Influential Factors

“…The accuracy of temperature prediction with the governing equations of different bioheat transfer models presented in " Materials and Methods " section tremendously depends on the thermal properties of the tissue under consideration. It is a common practice to treat the thermal properties of the tissue (viz., thermal conductivity, volumetric heat capacity, and thermal diffusivity) as constant, generally at room temperature, during computational modeling of thermal therapies [ 10 , 32 , 33 , 36 , 47 , 49 , 52 , 53 ]. This simplified assumption is also considered due to the lack of experimental data available in the literature related to the thermal characterization of biological tissues in the temperature range applicable for thermal therapies [ 54 ].…”

Numerical analysis of biological tissue heating using the dual-phase lag equation with temperature – dependent parameters

“…There are various types of mathematical models that describe the heat flow in living tissues in the literature. These are the Pennes equation [1], the Cattaneo-Vernotte equation [2,3], the dual-phase lag equation [4], the three-phase lag equation [5][6][7], models based on the theory of porous media [8] and models taking into account the presence of thermally significant blood vessels [9,10]. In order to determine the values of thermophysical parameters present in these models, intensive experimental studies of various types of tissues are carried out [11,12].…”