Three promising antimycobacterial medicinal plants reviewed as potential sources of drug hit candidates against multidrug-resistant tuberculosis

In vitro antimycobacterial activity of medicinal plants Lantana camara, Cryptolepis sanguinolenta, and Zanthoxylum leprieurii

“…The results showed that all methanolic extracts at the tested doses have significant different antimycobacterial activity against the tested mycobacteria strains, which indicates that these plants may contain one or a mixture of active ingredients responsible for the antimycobacterial activity. Different types of secondary metabolites, which are potentially resoponsible for antimycobacterial activity, have been identified ( Table 1 ) and reviewed in [30] . There is only limited knowledge on the specific mechanisms of action of those plant extracts on mycobacteria.…”

“…An ongoing study by our team looks at the metabolic fingerprinting of the methanolic extracts. Besides, the analysis of extracts from mycobacteria cultures with/without plant extracts treatment, will be conducted [30] .…”

“…Targetting DNA topoisomerase enzymes and inhibit bacterial growth. [30] , [39] Flavonoids Inhibition of nucleic acid synthesis, of cytoplasmic membrane function, of energy metabolism, of the attachment and biofilm formation, of the porins on the cell membrane, alteration of the membrane permeability, and attenuation of the pathogenicity. [40] Phenolic compounds Interactions with bacterial cells surface, hence bacteriual breakdown.…”

Optimized LC-MS/MS quantification of tuberculosis drug candidate macozinone (PBTZ169), its dearomatized Meisenheimer Complex and other metabolites, in human plasma and urine

“…Worldwide in 2019, close to half a million people developed rifampicin-resistant TB and the highest incidence of MDR-TB was found in countries of the former Soviet Union. As a consequence, new drugs overcoming the resistance to usual TB treatments are urgently needed to maintain the recent decrease in TB cases over the last few years [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] .…”

Design, Synthesis, and Antifungal Evaluation of Cryptolepine Derivatives against Phytopathogenic Fungi

“…The extraction and separation test revealed that it contains cryptolepine, neocryptolepine, quindoline, hydroxycryptolepine, and other ingredients. Further research revealed that the main component cryptolepine, whose total synthesis was prior to separation and determination, had exhibited unprecedented pharmacological effects, including antimalarial activity, − antibacterial activity, − anticancer activity, − antifungal activity, − anti-inflammatory activity, , antidiabetic activity, antituberculosis activity, and so on. − Although fruitful achievements had been widely reported, the exploration of cryptolepine and its derivatives in fungicide chemistry was barely conducted. This implied us that more emphasis should be laid on the study of cryptolepine and its derivatives in the control of crop fungi.…”