Three Types of Adverse Childhood Experiences, and Alcohol and Drug Dependence Among Adults: An Investigation Using Population-Based Data

Fuller‐Thomson, Esme; Roane, Jessica L.; Brennenstuhl, Sarah

doi:10.1080/10826084.2016.1181089

Cited by 68 publications

(52 citation statements)

References 38 publications

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“…Fuller-Thomson and colleagues found that participants who reported sexual abuse were almost three times and twice as likely to have drug and alcohol dependence, respectively, compared to participants who did not report sexual abuse [49]. Also, living with someone who has been incarcerated and who has mental health issues may be linked to substance use in adulthood as family members who were incarcerated or experienced mental health issues may have been more likely to abuse substances.…”

Section: Discussionmentioning

confidence: 99%

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Sex Disparities in Adverse Childhood Experiences and HIV/STIs: Mediation of Psychopathology and Sexual Behaviors

et al. 2016

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HIV and other sexually transmitted infections (STIs) are important public health challenges in the US. Adverse childhood experiences (ACEs), including abuse (emotional, physical or sexual), witnessing violence among household members, may have an effect on sexual behaviors, which increase the risk of HIV/STIs. The aim of this study was to examine the sex differences in the role of posttraumatic stress disorder (PTSD), major depression (MD), substance use disorders (SUDs), early sexual debut, and intimate partner violence (IPV) perpetration as mediators in the association between ACEs and HIV/STIs. Data were obtained from Wave 2 (2004–2005) of the National Epidemiologic Survey on Alcohol and Related Conditions. Structural equation modeling was used to determine the role of PTSD, MD, SUDs, early sexual debut, and IPV perpetration as mediators in the relationships between ACEs and HIV/STIs. Differences and similarities existed in the mediational roles of psychopathology and sexual behaviors. For example, among men, MD fully mediated physical/psychological abuse (β = 0.0002; p = 0.012) and sexual abuse (β = 0.0002; p = 0.006), and HIV/STIs while among women, MD fully mediated physical/psychological abuse (β = 0.0005; p < 0.001) and parental violence (β = −0.0002; p = 0.012). Among men, IPV perpetration fully mediated sexual abuse (β = −0.0005; p = 0.012) and HIV/STIs while among women, IPV perpetration was not a statistically significant mediator. HIV/STI prevention and intervention programs should use a life course approach by addressing adverse childhood events among men and women and consider the sex differences in the roles of psychopathology and sexual behaviors.

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Section: Discussionmentioning

confidence: 99%

“…This consistency provides support for the construct validity of the NESARC ACE questionnaire. The questions used in the ACE questionnaire in NESARC also cover adverse events that have been used in several studies examining ACEs [49–53]. …”

Section: Methodsmentioning

confidence: 99%

Sex Disparities in Adverse Childhood Experiences and HIV/STIs: Mediation of Psychopathology and Sexual Behaviors

et al. 2016

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“…Clinical studies indicate a strong positive relationship between repeated adverse childhood experiences and substance use disorders in adulthood (Fuller-Thomson et al, 2016; Gerra et al, 2016; Giordano et al, 2014; Koskenvuo & Koskenvuo, 2015; LeTendre & Reed, 2017; Merrick et al, 2017; Rossow & Lauritzen, 2001). In the small number of clinical studies that have examined accumbal function in either human adolescents or adults reporting experiences of repeated social and non-social juvenile stress, hypoactivity of the NAc in response to either reward-related stimuli or reward anticipation is observed (Goff et al, 2013; Boecker et al 2014; Corral-Frias et al, 2015; Hanson et al, 2015, 2016; but see Casement et al, 2014).…”

Section: Impact Of Chronic Juvenile Stress On Nucleus Accumbens Anmentioning

confidence: 99%

Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction

Watt

Weber

Davies

et al. 2017

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Repeated exposure to stress during childhood is associated with increased risk for neuropsychiatric illness, substance use disorders and other behavioral problems in adulthood. However, it is not clear how chronic childhood stress can lead to emergence of such a wide range of symptoms and disorders in later life. One possible explanation lies in stress-induced disruption to the development of specific brain regions associated with executive function and reward processing, deficits in which are common to the disorders promoted by childhood stress. Evidence of aberrations in prefrontal cortex and nucleus accumbens function following repeated exposure of juvenile (pre- and adolescent) organisms to a variety of different stressors would account not only for the similarity in symptoms across the wide range of childhood stress-associated mental illnesses, but also their persistence into adulthood in the absence of further stress. Therefore, the goal of this review is to evaluate the current knowledge regarding disruption to executive function and reward processing in adult animals or humans exposed to chronic stress over the juvenile period, and the underlying neurobiology, with particular emphasis on the prefrontal cortex and nucleus accumbens. First, the role of these brain regions in mediating executive function and reward processing is highlighted. Second, the neurobehavioral development of these systems is discussed to illustrate how juvenile stress may exert long-lasting effects on prefrontal cortex-accumbal activity and related behavioral functions. Finally, a critical review of current animal and human findings is presented, which strongly supports the supposition that exposure to chronic stress (particularly social aggression and isolation in animal studies) in the juvenile period produces impairments in executive function in adulthood, especially in working memory and inhibitory control. Chronic juvenile stress also results in aberrations to reward processing and seeking, with increased sensitivity to drugs of abuse particularly noted in animal models, which is in line with greater incidence of substance use disorders seen in clinical studies. These consequences are potentially mediated by monoamine and glutamatergic dysfunction in the prefrontal cortex and nucleus accumbens, providing translatable therapeutic targets. However, the predominant use of male subjects and social-based stressors in preclinical studies points to a clear need for determining how both sex differences and stressor heterogeneity may differentially contribute to stress-induced changes to substrates mediating executive function and reward processing, before the impact of chronic juvenile stress in promoting adult psychopathology can be fully understood.

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“…Researchers have consistently identified associations between ETV and negative psychosocial and health outcomes (Boynton-Jarrett, Ryan, Berkman, & Wright, 2008;Dahlberg & Potter, 2001;Fuller-Thomson, Roane, & Brennenstuhl, 2016;Goldstick, Carter et al, 2017;Gorman-Smith, Henry, & Tolan, 2004;Herrenkohl et al, 2000;Schilling, Aseltine, & Gore, 2007), and these associations are often conceptualized as mediated by psychological distresses (Deane et al, 2016). In particular, ETV places adolescents at increased risk of internalizing problems, including major depressive disorders and posttraumatic stress disorder (Deane et al, 2016;Sheidow et al, 2014).…”

mentioning

confidence: 99%

Age‐Specific Associations Between Violence Exposure and Past 30‐Day Marijuana and Alcohol Use

Goldstick

Heinze

Stoddard

et al. 2018

J of Research on Adolesc

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Using data from a cohort study of students at risk for high school dropout, we examined associations between violence exposure and past 30-day alcohol and marijuana use. We used varying-coefficient regression with person-level fixed effects to estimate how those associations changed within-person across ages approximately 14-23. Generally, violence perpetration was most strongly associated with substance use, within-person. Substance use became increasingly associated with both observed violence and violence perpetration during early/middle adolescence; this increase continued longer into development (age 18+) for alcohol use. Across most of the age range studied here, violence victimization was minimally associated with within-person changes in substance use. Results indicate age-specific associations between violence exposure and alcohol and other drug use, which may be useful for informing prevention strategies.

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Three Types of Adverse Childhood Experiences, and Alcohol and Drug Dependence Among Adults: An Investigation Using Population-Based Data

Abstract: Three types of ACEs, including direct and indirect forms of violence, are independently related to lifetime drug and alcohol dependence among adult Canadians.

Cited by 68 publications

References 38 publications

Sex Disparities in Adverse Childhood Experiences and HIV/STIs: Mediation of Psychopathology and Sexual Behaviors

Sex Disparities in Adverse Childhood Experiences and HIV/STIs: Mediation of Psychopathology and Sexual Behaviors

Impact of juvenile chronic stress on adult cortico-accumbal function: Implications for cognition and addiction

Age‐Specific Associations Between Violence Exposure and Past 30‐Day Marijuana and Alcohol Use

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